Evidence map›Paper›PMID 26108385›Full record

ArticleACS nano2015

Inducing Stem Cell Myogenesis Using NanoScript.

Sahishnu Patel, Perry T Yin, Hiroshi Sugiyama, Ki-Bum Lee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS nano, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 26 citations in OpenAlex.

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  7. Delivery of transcription factors as modulators of cell differentiation.Drug delivery and translational research · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Sahishnu Patel†Department of Chemistry and Chemical Biology and ‡Department of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, United States.
Perry T Yin†Department of Chemistry and Chemical Biology and ‡Department of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, United States.
Hiroshi Sugiyama†Department of Chemistry and Chemical Biology and ‡Department of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, United States.
Ki-Bum Lee†Department of Chemistry and Chemical Biology and ‡Department of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, United States.
Kyoto University · JPRutgers, The State University of New Jersey · US

Funding

Combinatorial approaches for studying multiple cues regulating human pluripotentDP2OD006462 · OD · RUTGERS, THE STATE UNIV OF N.J. · PI LEE, KIBUM · 2009 to 2009
$2.3M
Novel magnetic core/shell nanoparticle-based stem cell therapy to direct neural sR21NS085569 · NINDS · RUTGERS, THE STATE UNIV OF N.J. · PI LEE, KIBUM · 2013 to 2014
$421k
NCCDPHP CDC HHS 1DP20D006462-01NIH HHS DP2 OD006462NINDS NIH HHS 1R21NS085569-01NINDS NIH HHS R21 NS085569
6 · The paper itself

Abstract

Transcription factors (TFs) are multidomain proteins that play a critical role in orchestrating stem cell differentiation, but several limitations hinder the full potential of TF-based gene regulation. Here we report a unique strategy to emulate TFs and differentiate stem cells in a nonviral approach using an artificial, nanoparticle-based transcription factor called NanoScript. The NanoScript platform consists of a gold nanoparticle functionalized with small molecules that mimic the various domains of TFs. As a result, NanoScript mimics the function and structure of TF proteins. Specifically, NanoScript was designed to regulate muscle cell differentiation by targeting myogenic regulatory factors (MRFs), which play an important role in inducing myogenesis. This NanoScript-MRF is stable in physiological environments, localizes within the nucleus, induces differentiation of adipose-derived mesenchymal stem cells into mature muscle cells in 7 days, and is naturally excreted from induced muscle cells. As such, NanoScript represents a safe and powerful tool for applications requiring gene manipulation.

Indexed as

Metal NanoparticlesMuscle DevelopmentCell DifferentiationCell LineGoldHumansMesenchymal Stem CellsMuscle CellsMyogenic Regulatory FactorsGoldMyogenic Regulatory Factorsmyogenesisnanoparticle-based genetic manipulationnonviral deliverystem cell differentiationtranscription factors

Identifiers

PMID26108385
PMCPMC5808887
OpenAlexW2318663109

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.