ArticleNature communications2015
Caenorhabditis elegans is a useful model for anthelmintic discovery.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 114 papers.
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Who cites it
114 citing papers in PubMed.
- Lichens as a Source of Nematocidal Compounds: Identification of Sphaerophorin and Divaricatic Acid Active againstACS omega · 2026Article
- The nematode Caenorhabditis elegans has a cationic amphiphilic drug (CAD) defense system.PLoS biology · 2026Article
- Fluopyram analogues containing a five-membered heterocyclic ring moiety: synthesis, nematicidal activity and molecular docking study.Molecular diversity · 2026Article
- The Nematicide Tioxazafen Disrupts Proteasome Function via Cytochrome P450 Bioactivation.bioRxiv : the preprint server for biology · 2026Article
- Probing Cinnamamides and Benzamides as Anthelmintics: Discovery of Potent Drug-Like Agents Against Angiostrongylus cantonensis.Chemical biology & drug design · 2026Article
- Contextual Representation Learning With ResNet Refinement and Deep Classification for Enhanced Drug Target Interaction Prediction.Chemical biology & drug design · 2026Article
- Article
- Reviewing the thoroughness of human safety testing for succinate dehydrogenase inhibitors: fluopyram as a case study.Archives of toxicology · 2026Review
- Article
- Distinct anthelmintic classes do not affect gut bacteria, and bacteria do not alter nematocidal efficacy inmicroPublication biology · 2026Article
- Chemical perturbation reveals a cytoskeletal-trafficking vulnerability inFrontiers in pharmacology · 2026Article
- Synthesis, Anthelmintic Activity, and Mechanism of Action of 5-Aryl-1Journal of agricultural and food chemistry · 2025Article
- Fluopyram analogues containing an indole moiety: synthesis, biological activity and molecular docking study.Molecular diversity · 2025Article
- Pelodera: cosmopolitan phoretic saprotrophs and neglected models for origins of nematode parasitism.Parasites & vectors · 2025Review
- Magnolol and Honokiol Are Novel Antiparasitic Compounds fromACS omega · 2025Article
- Discovery of small molecules with anthelmintic potential in the Medicines for Malaria Venture's COVID and Global Health Priority Boxes using an infrared-based assay for Caenorhabditis elegans motility.BMC research notes · 2025Article
- Drug screens using the nematode Caenorhabditis elegans.Genetics · 2025Review
- Advances in Anthelmintic Target Identification.International journal of molecular sciences · 2025Review
- Article
- Antimicrobial and antiparasitic potential of lupeol: antifungal effect on theJournal of medical microbiology · 2025Article
54 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issuedAuthor Correction: Caenorhabditis elegans is a useful model for anthelmintic discovery.2020 · Rajendran, Luckshika [corrected to Rajendran, Luckshi]
Authors and funding
22 authors.
Funding
Abstract
Parasitic nematodes infect one quarter of the world's population and impact all humans through widespread infection of crops and livestock. Resistance to current anthelmintics has prompted the search for new drugs. Traditional screens that rely on parasitic worms are costly and labour intensive and target-based approaches have failed to yield novel anthelmintics. Here, we present our screen of 67,012 compounds to identify those that kill the non-parasitic nematode Caenorhabditis elegans. We then rescreen our hits in two parasitic nematode species and two vertebrate models (HEK293 cells and zebrafish), and identify 30 structurally distinct anthelmintic lead molecules. Genetic screens of 19 million C. elegans mutants reveal those nematicides for which the generation of resistance is and is not likely. We identify the target of one lead with nematode specificity and nanomolar potency as complex II of the electron transport chain. This work establishes C. elegans as an effective and cost-efficient model system for anthelmintic discovery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.