ArticleHuman brain mapping2015
Perfusion shift from white to gray matter may account for processing speed deficits in schizophrenia.
Article in Human brain mapping, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Processing Speed Impairment in Schizophrenia: An Updated Systematic Review and Meta-Analysis.JAMA psychiatry · 2026Pooled it
- Heterochronicity of white matter development and aging explains regional patient control differences in schizophrenia.Human brain mapping · 2016Pooled it
- Exploring the Pathways Between Early Auditory Processing, Processing Speed, Social Cognition, and Negative Symptoms on Social Functioning in Individuals at Clinical High Risk for Psychosis: A Structural Equation Modeling Approach.Biological psychiatry · 2026Article
- Peripheral Microvascular and Cerebral White Matter Dysfunction in Schizophrenia: Implications of a Body-Brain Endothelial Pathophysiology.Schizophrenia bulletin · 2025Article
- Predicting Regional Cerebral Blood Flow Using Voxel-Wise Resting-State Functional MRI.Brain sciences · 2025Article
- A Systematic Review and Meta-Analysis of Arterial Spin Labeling Magnetic Resonance Imaging Studies in Psychosis Spectrum Disorders.Noro psikiyatri arsivi · 2025Review
- Accelerating Heritability, Genetic Correlation, and Genome-Wide Association Imaging Genetic Analyses in Complex Pedigrees.Human brain mapping · 2024Article
- Spatiotemporal Patterns of White Matter Maturation after Pre-Adolescence: A Diffusion Kurtosis Imaging Study.Brain sciences · 2024Article
- Microstructural Gray Matter Integrity Deteriorates After an Ischemic Stroke and Is Associated with Processing Speed.Translational stroke research · 2023Article
- Neurodevelopmental model of schizophrenia revisited: similarity in individual deviation and idiosyncrasy from the normative model of whole-brain white matter tracts and shared brain-cognition covariation with ADHD and ASD.Molecular psychiatry · 2022Article
- Neuroimaging in schizophrenia: A review article.Frontiers in neuroscience · 2022Review
- A White Matter Connection of Schizophrenia and Alzheimer's Disease.Schizophrenia bulletin · 2021Article
- White matter structure in schizophrenia and autism: Abnormal diffusion across the brain in schizophrenia.Neuropsychologia · 2019Article
- Functional network connectivity impairments and core cognitive deficits in schizophrenia.Human brain mapping · 2019Article
- Increased white matter metabolic rates in autism spectrum disorder and schizophrenia.Brain imaging and behavior · 2018Article
- Basal ganglia cerebral blood flow associates with psychomotor speed in adults with type 1 diabetes.Brain imaging and behavior · 2018Article
- Miniature pig model of human adolescent brain white matter development.Journal of neuroscience methods · 2018Article
- Integration of routine QA data into mega-analysis may improve quality and sensitivity of multisite diffusion tensor imaging studies.Human brain mapping · 2018Article
- Association of White Matter With Core Cognitive Deficits in Patients With Schizophrenia.JAMA psychiatry · 2017Article
- Fornix Structural Connectivity and Allostatic Load: Empirical Evidence From Schizophrenia Patients and Healthy Controls.Psychosomatic medicine · 2017Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Reduced speed of cerebral information processing is a cognitive deficit associated with schizophrenia. Normal information processing speed (PS) requires intact white matter (WM) physiology to support information transfer. In a cohort of 107 subjects (47/60 patients/controls), we demonstrate that PS deficits in schizophrenia patients are explained by reduced WM integrity, which is measured using diffusion tensor imaging, mediated by the mismatch in WM/gray matter blood perfusion, and measured using arterial spin labeling. Our findings are specific to PS, and testing this hypothesis for patient-control differences in working memory produces no explanation. We demonstrate that PS deficits in schizophrenia can be explained by neurophysiological alterations in cerebral WM. Whether the disproportionately low WM integrity in schizophrenia is due to illness or secondary due to this disorder deserves further examination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.