Evidence map›Paper›PMID 26107991›Full record

ArticleEndocrinology2015

Olfactomedin 1 Deficiency Leads to Defective Olfaction and Impaired Female Fertility.

Rong Li, Honglu Diao, Fei Zhao, Shuo Xiao, Ahmed E El Zowalaty, Elizabeth A Dudley, Mark P Mattson, Xiaoqin Ye

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Observational
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Rong LiDepartment of Physiology and Pharmacology (R.L., H.D., F.Z., S.X., A.E.E.Z., E.A.D., X.Y.), College of Veterinary Medicine, and Interdisciplinary Toxicology Program (R.L., F.Z., S.X., A.E.E.Z., E.A.D., X.Y.), University of Georgia, Athens, Georgia 30602; and Laboratory of Neurosciences (M.P.M.), National Institute on Aging Intramural Research Program, Baltimore, Maryland 21224.
Honglu DiaoDepartment of Physiology and Pharmacology (R.L., H.D., F.Z., S.X., A.E.E.Z., E.A.D., X.Y.), College of Veterinary Medicine, and Interdisciplinary Toxicology Program (R.L., F.Z., S.X., A.E.E.Z., E.A.D., X.Y.), University of Georgia, Athens, Georgia 30602; and Laboratory of Neurosciences (M.P.M.), National Institute on Aging Intramural Research Program, Baltimore, Maryland 21224.
Fei ZhaoDepartment of Physiology and Pharmacology (R.L., H.D., F.Z., S.X., A.E.E.Z., E.A.D., X.Y.), College of Veterinary Medicine, and Interdisciplinary Toxicology Program (R.L., F.Z., S.X., A.E.E.Z., E.A.D., X.Y.), University of Georgia, Athens, Georgia 30602; and Laboratory of Neurosciences (M.P.M.), National Institute on Aging Intramural Research Program, Baltimore, Maryland 21224.
Shuo XiaoDepartment of Physiology and Pharmacology (R.L., H.D., F.Z., S.X., A.E.E.Z., E.A.D., X.Y.), College of Veterinary Medicine, and Interdisciplinary Toxicology Program (R.L., F.Z., S.X., A.E.E.Z., E.A.D., X.Y.), University of Georgia, Athens, Georgia 30602; and Laboratory of Neurosciences (M.P.M.), National Institute on Aging Intramural Research Program, Baltimore, Maryland 21224.
Ahmed E El ZowalatyDepartment of Physiology and Pharmacology (R.L., H.D., F.Z., S.X., A.E.E.Z., E.A.D., X.Y.), College of Veterinary Medicine, and Interdisciplinary Toxicology Program (R.L., F.Z., S.X., A.E.E.Z., E.A.D., X.Y.), University of Georgia, Athens, Georgia 30602; and Laboratory of Neurosciences (M.P.M.), National Institute on Aging Intramural Research Program, Baltimore, Maryland 21224.
Elizabeth A DudleyDepartment of Physiology and Pharmacology (R.L., H.D., F.Z., S.X., A.E.E.Z., E.A.D., X.Y.), College of Veterinary Medicine, and Interdisciplinary Toxicology Program (R.L., F.Z., S.X., A.E.E.Z., E.A.D., X.Y.), University of Georgia, Athens, Georgia 30602; and Laboratory of Neurosciences (M.P.M.), National Institute on Aging Intramural Research Program, Baltimore, Maryland 21224.
Mark P MattsonDepartment of Physiology and Pharmacology (R.L., H.D., F.Z., S.X., A.E.E.Z., E.A.D., X.Y.), College of Veterinary Medicine, and Interdisciplinary Toxicology Program (R.L., F.Z., S.X., A.E.E.Z., E.A.D., X.Y.), University of Georgia, Athens, Georgia 30602; and Laboratory of Neurosciences (M.P.M.), National Institute on Aging Intramural Research Program, Baltimore, Maryland 21224.
Xiaoqin YeDepartment of Physiology and Pharmacology (R.L., H.D., F.Z., S.X., A.E.E.Z., E.A.D., X.Y.), College of Veterinary Medicine, and Interdisciplinary Toxicology Program (R.L., F.Z., S.X., A.E.E.Z., E.A.D., X.Y.), University of Georgia, Athens, Georgia 30602; and Laboratory of Neurosciences (M.P.M.), National Institute on Aging Intramural Research Program, Baltimore, Maryland 21224.
University of Georgia · USInstitute on Aging · US

Funding

Molecular mechanism of LPA3-mediated uterine receptivityR01HD065939 · NICHD · UNIVERSITY OF GEORGIA · PI YE, XIAOQIN · 2011 to 2015
$1.5M
Luminal epithelial microenvironment in Lpar3(-/-) peri-implantation uterusR15HD066301 · NICHD · UNIVERSITY OF GEORGIA · PI YE, XIAOQIN · 2010 to 2010
$371k
Intramural NIH HHSNICHD NIH HHS R01 HD065939NICHD NIH HHS R01HD065939NICHD NIH HHS R15 HD066301NICHD NIH HHS R15HD066301
6 · The paper itself

Abstract

Olfactomedin 1 (OLFM1) is a glycoprotein highly expressed in the brain. Olfm1(-/-) female mice were previously reported to have reduced fertility. Previous microarray analysis revealed Olfm1 among the most highly upregulated genes in the uterine luminal epithelium upon embryo implantation, which was confirmed by in situ hybridization. We hypothesized that Olfm1 deficiency led to defective embryo implantation and thus impaired fertility. Indeed, Olfm1(-/-) females had defective embryo implantation. However, Olfm1(-/-) females rarely mated and those that mated rarely became pregnant. Ovarian histology indicated the absence of corpora lutea in Olfm1(-/-) females, indicating defective ovulation. Superovulation using equine chorionic gonadotropin-human chorionic gonadotropin rescued mating, ovulation, and pregnancy, and equine chorionic gonadotropin alone rescued ovulation in Olfm1(-/-) females. Olfm1(-/-) females had a 13% reduction of hypothalamic GnRH neurons but comparable basal serum LH levels and GnRH-induced LH levels compared with wild-type controls. These results indicated no obvious local defects in the female reproductive system and a functional hypothalamic-pituitary-gonadal axis. Olfm1(-/-) females were unresponsive to the effects of male bedding stimulation on pubertal development and estrous cycle. There were 41% fewer cFos-positive cells in the mitral cell layer of accessory olfactory bulb upon male urine stimulation for 90 minutes. OLFM1 was expressed in the main and accessory olfactory systems including main olfactory epithelium, vomeronasal organ, main olfactory bulb, and accessory olfactory bulb, with the highest expression detected in the axon bundles of olfactory sensory neurons. These data demonstrate that defective fertility in Olfm1(-/-) females is most likely a secondary effect of defective olfaction.

Indexed as

FertilitySmellAnimalsEmbryo ImplantationExtracellular Matrix ProteinsFemaleGlycoproteinsHypothalamusLuteinizing HormoneMaleMice, 129 StrainOdorantsOlfactory BulbOlfactory Receptor NeuronsOvulationRandom AllocationExtracellular Matrix ProteinsGlycoproteinsLuteinizing Hormoneolfactomedin

Identifiers

PMID26107991
PMCPMC4541623
OpenAlexW2217058935

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.