ArticlePloS one2015
Early-onset atopic dermatitis in children: which are the phenotypes at risk of asthma? Results from the ORCA cohort.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Classifying atopic dermatitis: a systematic review of phenotypes and associated characteristics.Journal of the European Academy of Dermatology and Venereology : JEADV · 2022Pooled it
- Whole-cell pertussis vaccine in early infancy for the prevention of allergy in children.The Cochrane database of systematic reviews · 2021Pooled it
- BCG Vaccination in Early Childhood and Risk of Atopic Disease: A Systematic Review and Meta-Analysis.Canadian respiratory journal · 2021Pooled it
- Identification of two early life eczema and non-eczema phenotypes with high risk for asthma development.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2019Trial
- Inborn Errors of Immunity Presenting with Early-Onset Severe Atopy.Medicina (Kaunas, Lithuania) · 2025Review
- Machine learning-derived phenotypic trajectories of asthma and allergy in children and adolescents: protocol for a systematic review.BMJ open · 2024Article
- Development of a multivariate predictive nomogram among women with antepartum fetal death diagnosed at ≥ 34 weeks of gestation for outcome of TOLAC.Archives of gynecology and obstetrics · 2024Observational
- Pediatric asthma comorbidities: Global impact and unmet needs.The World Allergy Organization journal · 2024Review
- Risk of atopic dermatitis and the atopic march paradigm in children of mothers with atopic illnesses: A birth cohort study from the United Kingdom.Journal of the American Academy of Dermatology · 2024Article
- Phenotype of Atopic Dermatitis With Food Allergy Predicts Development of Childhood Asthma via Gut Wnt Signaling.Allergy, asthma & immunology research · 2022Article
- Atopic Dermatitis With Coexisting Food Allergy in Early Life Is Associated With Childhood Asthma.Allergy, asthma & immunology research · 2022Article
- Classification of atopic dermatitis phenotypes according to allergic sensitization by cluster analysis.The World Allergy Organization journal · 2022Article
- Atopic dermatitis trajectories to age 8 years in the GUSTO cohort.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2021Article
- Disease-associated and patient-specific immune cell signatures in juvenile-onset systemic lupus erythematosus: patient stratification using a machine-learning approach.The Lancet. Rheumatology · 2020Article
- Atopic dermatitis independently increases sensitization above parental atopy: The MPAACH study.The Journal of allergy and clinical immunology · 2020Article
- Parental and child factors associated with inhalant and food allergy in a population-based prospective cohort study: the Generation R Study.European journal of pediatrics · 2019Article
- Phenotypes of allergic diseases in children and their application in clinical situations.Korean journal of pediatrics · 2019Article
- Asthma and allergic rhinitis risk depends on house dust mite specific IgE levels in PARIS birth cohort children.The World Allergy Organization journal · 2019Article
- African ancestry is associated with cluster-based childhood asthma subphenotypes.BMC medical genomics · 2018Article
- Phenotypes of Atopic Dermatitis Depending on the Timing of Onset and Progression in Childhood.JAMA pediatrics · 2017Article
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAtopic dermatitis (AD) is known to predate asthma and other atopic disorders described under the term "atopic march". However, this classic sequence is not always present and only a few studies have addressed children at risk of developing asthma. The objective of this study is to define early-onset AD phenotypes leading to asthma.
methodsWe performed a cluster analysis with 9 variables of 214 infants with early-onset AD prospectively enrolled in the ORCA cohort and followed each year on the occurrence of asthma until the age of 6.
resultsWe identified 3 clusters - cluster 1 (n = 94) with low to no sensitization to food (27.7%) or aeroallergens (10.6%) and moderate AD severity (SCORAD 25.29 +/- 14.6) called "AD with low sensitization"; - cluster 2 (n = 84) characterized by a higher AD severity (SCORAD 32.66+/-16.6) and frequent sensitization to food (98.9%) or aeroallergens (26.2%), most likely multiple (96.4% for food allergens), called "AD with multiple sensitizations" - cluster 3 (n = 36) with parental history, moderate AD severity (SCORAD 24.46+/-15.7), moderate rate of sensitization to food allergens (38.9%) (exclusively single) with no sensitization to aeroallergens, called "AD with familial history of asthma". Percentages of children suffering from asthma at the age of 6 were higher in clusters 2 and 3 (36.1% and 33.3% respectively versus 14.9% in cluster 1, p<0.01).
conclusionTwo phenotypes in infants with early-onset AD convey a higher risk of developing asthma during childhood: multiple sensitization and familial history of asthma.
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