ArticlePloS one2015
Incidence and Risk Factors for Respiratory Syncytial Virus and Human Metapneumovirus Infections among Children in the Remote Highlands of Peru.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Respiratory syncytial virus burden in children under 2 years old in understudied areas worldwide: gap analysis of available evidence, 2012-2022.Frontiers in pediatrics · 2024Review
- Characteristics of Respiratory Syncytial Virus versus Influenza Infection in Hospitalized Patients of Peru: A Retrospective Observational Study.Tropical medicine and infectious disease · 2022Article
- Molecular epidemiological surveillance of viral agents of acute lower respiratory tract infections in children in Accra, Ghana.BMC pediatrics · 2022Article
- Effective Regulation of Gut Microbiota With Probiotics and Prebiotics May Prevent or Alleviate COVID-19 Through the Gut-Lung Axis.Frontiers in pharmacology · 2022Review
- The Burden of Respiratory Syncytial Virus in Children Under 2 Years of Age in a Rural Community in Maharashtra, India.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Epidemiology and Seasonality of Childhood Respiratory Syncytial Virus Infections in the Tropics.Viruses · 2021Review
- Clinical Features of Human Metapneumovirus-Associated Community-acquired Pneumonia Hospitalizations.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Assessing the Incidence of Symptomatic Respiratory Syncytial Virus Illness Within a Prospective Birth Cohort in Managua, Nicaragua.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
- Nasopharyngeal Pneumococcal Density during Asymptomatic Respiratory Virus Infection and Risk for Subsequent Acute Respiratory Illness.Emerging infectious diseases · 2019Article
- Risk factors and patterns of household clusters of respiratory viruses in rural Nepal.Epidemiology and infection · 2019Article
- Activity of the antioxidant enzyme paraoxonase in Argentinean children living at high altitude.Redox report : communications in free radical research · 2018Article
- Dynamics of Colonization ofOpen forum infectious diseases · 2018Article
- A novel real-time RT-PCR assay for influenza C tested in Peruvian children.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2017Article
- Emergence of ON1 genotype of human respiratory syncytial virus subgroup A in China between 2011 and 2015.Scientific reports · 2017Article
- Respiratory Syncytial Virus: Infection, Detection, and New Options for Prevention and Treatment.Clinical microbiology reviews · 2017Review
- Etiology of severe pneumonia in Ecuadorian children.PloS one · 2017Observational
- Spatial and Temporal Spread of Acute Viral Respiratory Infections in Young Children Living in High-altitude Rural Communities: A Prospective Household-based Study.The Pediatric infectious disease journal · 2016Article
- Respiratory syncytial virus infection in infants in rural Nepal.The Journal of infection · 2016Article
- Molecular Epidemiology of Rhinovirus Detections in Young Children.Open forum infectious diseases · 2016Article
- Respiratory Viral Detections During Symptomatic and Asymptomatic Periods in Young Andean Children.The Pediatric infectious disease journal · 2015Article
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Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
Abstract
introductionThe disease burden and risk factors for respiratory syncytial virus (RSV) and human metapneumovirus (MPV) infections among children living in remote, rural areas remain unclear. MATERIALS AND
methodsWe conducted a prospective, household-based cohort study of children aged <3 years living in remote rural highland communities in San Marcos, Cajamarca, Peru. Acute respiratory illnesses (ARI), including lower respiratory tract infection (LRTI), were monitored through weekly household visits from March 2009 through September 2011. Nasal swabs collected during ARI/LRTI were tested for RSV, MPV, and other respiratory viruses using real-time RT-PCR. Incidence rates and rate ratios were calculated using mixed effects Poisson regression.
resultsAmong 892 enrolled children, incidence rates of RSV and MPV ARI were 30 and 17 episodes per 100 child-years, respectively. The proportions of RSV and MPV ARI that presented as LRTI were 12.5% and 8.9%, respectively. Clinic visits for ARI and hospitalizations were significantly more frequent (all p values <0.05) among children with RSV (clinic 41% and hospital 5.3%) and MPV ARI (38% and 3.5%) when compared with other viral infections (23% and 0.7%) and infections without virus detected (24% and 0.6%). In multivariable analysis, risk factors for RSV detection included younger age (RR 1.02, 95% CI: 1.00-1.03), the presence of a smoker in the house (RR 1.63, 95% CI: 1.12-2.38), residing at higher altitudes (RR 1.93, 95% CI: 1.25-3.00 for 2nd compared to 1st quartile residents; RR 1.98, 95% CI: 1.26-3.13 for 3rd compared to 1st quartile residents). Having an unemployed household head was significantly associated with MPV risk (RR 2.11, 95% CI: 1.12-4.01).
conclusionIn rural high altitude communities in Peru, childhood ARI due to RSV or MPV were common and associated with higher morbidity than ARI due to other viruses or with no viral detections. The risk factors identified in this study may be considered for interventional studies to control infections by these viruses among young children from developing countries.
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