Evidence map›Paper›PMID 26107625›Full record

Trial reportPloS one2015

Microneutralization assay titres correlate with protection against seasonal influenza H1N1 and H3N2 in children.

Chris P Verschoor, Pardeep Singh, Margaret L Russell, Dawn M E Bowdish, Angela Brewer, Louis Cyr, Brian J Ward, Mark Loeb

Erratum issuedOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 95 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Trial
  5. Trial
  6. Trial
  7. Trial
  8. Article
  9. Article
  10. Article
  11. Review
  12. Observational
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Influenza Vaccine Effectiveness Against Illness and Asymptomatic Infection in 2022-2023: A Prospective Cohort Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025
    Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Chris P VerschoorMcMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada; Michael G DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.
Pardeep SinghDepartment of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.
Margaret L RussellCumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Dawn M E BowdishMcMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada; Michael G DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.
Angela BrewerResearch Institute of the McGill University Health Center, Montreal, QC, Canada.
Louis CyrResearch Institute of the McGill University Health Center, Montreal, QC, Canada.
Brian J WardResearch Institute of the McGill University Health Center, Montreal, QC, Canada.
Mark LoebMcMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada; Michael G DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada; Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.
McGill University Health Centre · CAMcMaster University Medical Centre · CAMcMaster University · CAUniversity of Calgary · CA

Funding

A randomized trial of influenza vaccination of Hutterite childrenU01AI076208 · NIAID · MCMASTER UNIVERSITY · PI LOEB, MARK · 2008 to 2010
$1.5M
CIHR MCT-88113NIAID NIH HHS 1 U01 AI 76208-01A1NIAID NIH HHS U01 AI076208
6 · The paper itself

Abstract

Although the microneutralization (MN) assay has been shown to be more sensitive than the hemagglutination inhibition (HAI) assay for the measurement of humoral immunity against influenza viruses, further evidence relating MN titres to protective efficacy against infection is needed. Serum antibodies against seasonal H1N1 and H3N2 influenza were measured in children and adolescents (n = 656) by MN and hemagglutination inhibition (HAI) assays. Compared to HAI, the MN assay is more sensitive in detecting serum antibodies and estimates of protective effectiveness against PCR-confirmed infection were higher for both subtypes. Given our findings, the MN assay warrants further consideration as a formal tool for the routine evaluation of vaccine-induced antibody responses.

Indexed as

Influenza A Virus, H1N1 SubtypeInfluenza A Virus, H3N2 SubtypeAdolescentAlbertaAntibodies, ViralAntibody FormationChildChild, PreschoolHemagglutination Inhibition TestsHemagglutinin Glycoproteins, Influenza VirusHumansImmunity, HumoralInfluenza, HumanInfluenza VaccinesManitobaNeutralization TestsAntibodies, ViralHemagglutinin Glycoproteins, Influenza Virushemagglutinin, human influenza A virusInfluenza Vaccines

Identifiers

PMID26107625
PMCPMC4479562
OpenAlexW1960083897

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.