ArticlePloS one2015
A Canine Non-Weight-Bearing Model with Radial Neurectomy for Rotator Cuff Repair.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The trial behind it
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Who cites it
6 citing papers in PubMed, 16 citations in OpenAlex.
- Establishing a rabbit model with massive supraspinatus tendon defect for investigating scaffold-assisted tendon repair.Biological procedures online · 2024Article
- The Effect of Pulling Angle on Rotator Cuff Mechanical Properties in a Canine In Vitro Model.Bioengineering (Basel, Switzerland) · 2023Article
- Large animal models for the study of tendinopathy.Frontiers in cell and developmental biology · 2022Review
- Biomechanical evaluation of a novel double rip-stop technique with medial row knots for rotator cuff repair: an in vitro study.Bone & joint research · 2020Article
- Current Status of Tissue-Engineered Scaffolds for Rotator Cuff Repair.Techniques in orthopaedics (Rockville, Md.) · 2016Article
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Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundThe major concern of using a large animal model to study rotator cuff repair is the high rate of repair retears. The purpose of this study was to test a non-weight-bearing (NWB) canine model for rotator cuff repair research.
methodsFirst, in the in vitro study, 18 shoulders were randomized to 3 groups. 1) Full-width transections repaired with modified Mason-Allen sutures using 3-0 polyglactin suture, 2) Group 1 repaired using number 2 (#2) polyester braid and long-chain polyethylene suture, and 3) Partial-width transections leaving the superior 2 mm infraspinatus tendon intact without repair. In the in vivo study of 6 dogs, the infraspinatus tendon was partially transected as the same as the in vitro group 3. A radial neurectomy was performed to prevent weight bearing. The operated limb was slung in a custom-made jacket for 6 weeks.
resultsIn the in vitro study, mean ultimate tensile load and stiffness in Group 2 were significantly higher than Group 1 and 3 (p<0.05). In the in vivo study, gross inspection and histology showed that the preserved superior 2-mm portion of the infraspinatus tendon remained intact with normal structure.
conclusionsBased on the biomechanical and histological findings, this canine NWB model may be an appropriate and useful model for studies of rotator cuff repair.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.