ArticlePLoS computational biology2015
Antenna Mechanism of Length Control of Actin Cables.
Article in PLoS computational biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Actin filament assembly driven by distributive polymerases clustered on membrane surfaces.bioRxiv : the preprint server for biology · 2025Article
- A generalized theoretical framework to investigate multicomponent actin dynamics.PLoS computational biology · 2025Article
- Design principles and feedback mechanisms in organelle size control.Current opinion in cell biology · 2025Review
- Reconstituted systems for studying the architecture and dynamics of actin networks.The Biochemical journal · 2025Review
- Length control emerges from cytoskeletal network geometry.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Length control emerges from cytoskeletal network geometry.bioRxiv : the preprint server for biology · 2023Article
- The effect of motor-induced shaft dynamics on microtubule stability and length.Biophysical journal · 2023Article
- Size regulation of multiple organelles competing for a limiting subunit pool.PLoS computational biology · 2022Article
- Effects of random hydrolysis on biofilament length distributions in a shared subunit pool.Biophysical journal · 2022Article
- Stochasticity and positive feedback enable enzyme kinetics at the membrane to sense reaction size.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- Stochastic combinations of actin regulatory proteins are sufficient to drive filopodia formation.The Journal of cell biology · 2021Article
- Control of filament length by a depolymerizing gradient.PLoS computational biology · 2020Article
- Integrated control of formin-mediated actin assembly by a stationary inhibitor and a mobile activator.The Journal of cell biology · 2018Article
- Physical Limits on the Precision of Mitotic Spindle Positioning by Microtubule Pushing forces: Mechanics of mitotic spindle positioning.BioEssays : news and reviews in molecular, cellular and developmental biology · 2017Review
- Article
- The final cut: cell polarity meets cytokinesis at the bud neck in S. cerevisiae.Cellular and molecular life sciences : CMLS · 2016Review
- Exact Length Distribution of Filamentous Structures Assembled from a Finite Pool of Subunits.The journal of physical chemistry. B · 2016Article
- Design Principles of Length Control of Cytoskeletal Structures.Annual review of biophysics · 2016Review
- Common formin-regulating sequences in Smy1 and Bud14 are required for the control of actin cable assembly in vivo.Molecular biology of the cell · 2016Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
Abstract
Actin cables are linear cytoskeletal structures that serve as tracks for myosin-based intracellular transport of vesicles and organelles in both yeast and mammalian cells. In a yeast cell undergoing budding, cables are in constant dynamic turnover yet some cables grow from the bud neck toward the back of the mother cell until their length roughly equals the diameter of the mother cell. This raises the question: how is the length of these cables controlled? Here we describe a novel molecular mechanism for cable length control inspired by recent experimental observations in cells. This "antenna mechanism" involves three key proteins: formins, which polymerize actin, Smy1 proteins, which bind formins and inhibit actin polymerization, and myosin motors, which deliver Smy1 to formins, leading to a length-dependent actin polymerization rate. We compute the probability distribution of cable lengths as a function of several experimentally tuneable parameters such as the formin-binding affinity of Smy1 and the concentration of myosin motors delivering Smy1. These results provide testable predictions of the antenna mechanism of actin-cable length control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.