Evidence map›Paper›PMID 26106961›Full record

Observational studyClinics (Sao Paulo, Brazil)2015

Naming ability in patients with mild to moderate Alzheimer's disease: what changes occur with the evolution of the disease?

Marcela Lima Silagi, Paulo Henrique Ferreira Bertolucci, Karin Zazo Ortiz

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in Clinics (Sao Paulo, Brazil), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

  1. A systematic literature review of automatic Alzheimer's disease detection from speech and language.Journal of the American Medical Informatics Association : JAMIA · 2020
    Pooled it
  2. Trial
  3. TQ-DAV: Action Naming Test with Videos for Quebec French.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2026
    Observational
  4. Article
  5. Cross-cultural Diagnostic Validity of the Multilingual Naming Test (MINT) in a Sample of Older Adults.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2024
    Article
  6. Article
  7. Observational
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. A tutorial on discourse analysis in healthy and pathological ageing.International journal of language & communication disorders
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Marcela Lima SilagiDepartment of Speech Therapy, Universidade Federal de São Paulo, São Paulo/, SP, Brazil.
Paulo Henrique Ferreira BertolucciSector of Behavior Neurology, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Karin Zazo OrtizDepartment of Speech Therapy, Universidade Federal de São Paulo, São Paulo/, SP, Brazil.
Universidade Federal de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesNaming deficit is a linguistic symptom that appears in the initial phase of Alzheimer's disease, but the types of naming errors and the ways in which this deficit changes over the course of the disease are unclear. We analyzed the performance of patients with Alzheimer's disease on naming tasks during the mild and moderate phases and verified how this linguistic skill deteriorates over the course of the disease.

methodsA reduced version of the Boston Naming Test was administered to 30 patients with mild Alzheimer's disease, 30 patients with moderate Alzheimer's disease and 30 healthy controls. Errors were classified as verbal semantic paraphasia, verbal phonemic paraphasia, no response (pure anomia), circumlocution, unrelated verbal paraphasia, visual errors or intrusion errors.

resultsThe patients with moderate Alzheimer's disease had significantly fewer correct answers than did both the control group and the group with mild Alzheimer's disease. With regard to the pattern of errors, verbal semantic paraphasia errors were the most frequent errors in all three groups. Additionally, as the disease severity increased, there was an increase in the number of no-response errors (pure anomia). The group with moderate Alzheimer's disease demonstrated a greater incidence of visual errors and unrelated verbal paraphasias compared with the other two groups and presented a more variable pattern of errors.

conclusionsPerformance on nominative tasks worsened as the disease progressed in terms of both the quantity and the type of errors encountered. This result reflects impairment at different levels of linguistic processing.

Indexed as

Disease ProgressionAgedAged, 80 and overAlzheimer DiseaseAnalysis of VarianceAnomiaAphasiaCross-Sectional StudiesEducational StatusHumansNeuropsychological TestsSemanticsSeverity of Illness IndexVisual Perception

Identifiers

PMID26106961
PMCPMC4462568
OpenAlexW2219188686

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.