Evidence map›Paper›PMID 26106930›Full record

ReviewBrain connectivity2015

Characterizing Resting-State Brain Function Using Arterial Spin Labeling.

J Jean Chen, Kay Jann, Danny J J Wang

Abstract readReview
In one paragraph

Review in Brain connectivity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  19. Rest Functional Brain Maturation during the First Year of Life.Cerebral cortex (New York, N.Y. : 1991) · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

J Jean Chen1 Rotman Research Institute, Baycrest Centre for Geriatric Care , Toronto, Canada .
Kay Jann3 Laboratory of Functional MRI Technology, Department of Neurology, University of California Los Angeles , Los Angeles, California.
Danny J J Wang3 Laboratory of Functional MRI Technology, Department of Neurology, University of California Los Angeles , Los Angeles, California.

Funding

Understanding Repetitive Behavior in AutismP50HD055784 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BOOKHEIMER, SUSAN Y · 2007 to 2021
$32.0M
Pediatric Template of Brain PerfusionR01MH080892 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI WANG, DANNY JJ · 2009 to 2013
$3.3M
Non-contrast 4-D Dynamic MRA in Arteriovenous Malformation (AVM)R01EB014922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI WANG, DANNY JJ · 2013 to 2016
$1.8M
Arterial Spin Labeled Perfusion MRI in Acute Ischemic StrokeR01NS081077 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WANG, DANNY JJ · 2012 to 2014
$1.3M
Canadian Institutes of Health ResearchNIBIB NIH HHS R01-EB014922NICHD NIH HHS P50 HD055784NIMH NIH HHS R01-MH080892NINDS NIH HHS R01-NS081077
6 · The paper itself

Abstract

Arterial spin labeling (ASL) is an increasingly established magnetic resonance imaging (MRI) technique that is finding broader applications in studying the healthy and diseased brain. This review addresses the use of ASL to assess brain function in the resting state. Following a brief technical description, we discuss the use of ASL in the following main categories: (1) resting-state functional connectivity (FC) measurement: the use of ASL-based cerebral blood flow (CBF) measurements as an alternative to the blood oxygen level-dependent (BOLD) technique to assess resting-state FC; (2) the link between network CBF and FC measurements: the use of network CBF as a surrogate of the metabolic activity within corresponding networks; and (3) the study of resting-state dynamic CBF-BOLD coupling and cerebral metabolism: the use of dynamic CBF information obtained using ASL to assess dynamic CBF-BOLD coupling and oxidative metabolism in the resting state. In addition, we summarize some future challenges and interesting research directions for ASL, including slice-accelerated (multiband) imaging as well as the effects of motion and other physiological confounds on perfusion-based FC measurement. In summary, this work reviews the state-of-the-art of ASL and establishes it as an increasingly viable MRI technique with high translational value in studying resting-state brain function.

Indexed as

BrainBrain MappingCerebrovascular CirculationConnectomeHumansMagnetic Resonance ImagingOxygenRestSpin LabelsOxygenSpin Labelsarterial-spin labelingarterial transit timecerebral blood flowfunctional connectivityfunctional magnetic resonance imagingneurovascular couplingperfusionwater permeability

Identifiers

PMID26106930
PMCPMC4652156

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.