ArticleAmerican journal of respiratory and critical care medicine2015
Timing and Duration of Traffic-related Air Pollution Exposure and the Risk for Childhood Wheeze and Asthma.
Article in American journal of respiratory and critical care medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
62 citing papers in PubMed, 2 syntheses or guidelines pooled it, 119 citations in OpenAlex.
- Long-term exposure to elemental carbon and disease incidence: a systematic review and meta-analysis.Environmental health : a global access science source · 2025Pooled it
- Traffic-Related Air Pollution and Childhood Asthma: Recent Advances and Remaining Gaps in the Exposure Assessment Methods.International journal of environmental research and public health · 2017Pooled it
- A review of indoor air quality interventions and child neurobehavioral outcomes.Pediatric research · 2026Review
- Individual and combined effects of indoor home exposures and ambient PMEnvironmental epidemiology (Philadelphia, Pa.) · 2026Article
- The role of the early-life gut microbiome in childhood asthma.Gut microbes · 2025Review
- International fluoride symposium: effects of fluoride on human health and its mechanisms of action - a meeting report.BMC proceedings · 2025Article
- Climate Change and the Future of Allergies and Asthma.Current allergy and asthma reports · 2025Review
- Sleep moderates how prenatal and childhood pollutant exposure impacts white matter microstructural integrity in adolescence.Npj biological timing and sleep · 2025Article
- A call for solutions-oriented research and policy to protect children from the effects of climate change.Pediatric research · 2024Article
- Windows of susceptibility and joint effects of prenatal and postnatal ambient air pollution and temperature exposure on asthma and wheeze in Mexican children.Environment international · 2024Article
- Prenatal and childhood air pollution exposure, cellular immune biomarkers, and brain connectivity in early adolescents.Brain, behavior, & immunity - health · 2024Article
- Development of a multimodal geomarker pipeline to assess the impact of social, economic, and environmental factors on pediatric health outcomes.Journal of the American Medical Informatics Association : JAMIA · 2024Article
- Early-Life Exposure to Air Pollution and Childhood Asthma Cumulative Incidence in the ECHO CREW Consortium.JAMA network open · 2024Article
- Exposure variables in veterinary epidemiology: are they telling us what we think they are?Frontiers in veterinary science · 2024Article
- Incidence rates of childhood asthma with recurrent exacerbations in the US Environmental influences on Child Health Outcomes (ECHO) program.The Journal of allergy and clinical immunology · 2023Article
- Air pollution exposure and social responsiveness in childhood: The cincinnati combined childhood cohorts.International journal of hygiene and environmental health · 2023Article
- Built environment factors predictive of early rapid lung function decline in cystic fibrosis.Pediatric pulmonology · 2023Article
- Environmental justice and allergic disease: A Work Group Report of the AAAAI Environmental Exposure and Respiratory Health Committee and the Diversity, Equity and Inclusion Committee.The Journal of allergy and clinical immunology · 2023Article
- Risk Factors Affecting Development and Persistence of Preschool Wheezing: Consensus Document of the Emilia-Romagna Asthma (ERA) Study Group.Journal of clinical medicine · 2022Article
- Multiancestral polygenic risk score for pediatric asthma.The Journal of allergy and clinical immunology · 2022Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
rationaleThe timing and duration of traffic-related air pollution (TRAP) exposure may be important for childhood wheezing and asthma development.
objectivesWe examined the relationship between TRAP exposure and longitudinal wheezing phenotypes and asthma at age 7 years.
methodsChildren completed clinical examinations annually from age 1 year through age 4 years and age 7 years. Parental-reported wheezing was assessed at each age, and longitudinal wheezing phenotypes (early-transient, late-onset, persistent) and asthma were defined at age 7 years. Participants' time-weighted exposure to TRAP, from birth through age 7 years, was estimated using a land-use regression model. The relationship between TRAP exposure and wheezing phenotypes and asthma was examined. MEASUREMENTS AND MAIN
resultsHigh TRAP exposure at birth was significantly associated with both transient and persistent wheezing phenotypes (adjusted odds ratio [aOR] = 1.64; 95% confidence interval [CI], 1.04-2.57 and aOR = 2.31; 95% CI, 1.28-4.15, respectively); exposure from birth to age 1 year and age 1 to 2 years was also associated with persistent wheeze. Only children with high average TRAP exposure from birth through age 7 years were at significantly increased risk for asthma (aOR = 1.71; 95% CI, 1.01-2.88).
conclusionsEarly-life exposure to TRAP is associated with increased risk for persistent wheezing, but only long-term exposure to high levels of TRAP throughout childhood was associated with asthma development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.