ArticleJournal of policy analysis and management : [the journal of the Association for Public Policy Analysis and Management]2015
Can Genetics Predict Response to Complex Behavioral Interventions? Evidence from a Genetic Analysis of the Fast Track Randomized Control Trial.
Article in Journal of policy analysis and management : [the journal of the Association for Public Policy Analysis and Management], 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01653535 (Multisite Prevention of Conduct Problems), which is not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Multisite Prevention of Conduct Problems
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- A systematic review of gene-by-intervention studies of alcohol and other substance use.Development and psychopathology · 2021Pooled it
- The Family Check-up Intervention Moderates Polygenic Influences on Long-Term Alcohol Outcomes: Results from a Randomized Intervention Trial.Prevention science : the official journal of the Society for Prevention Research · 2019Trial
- Oxytocin Receptor Gene Variant Interacts with Intervention Delivery Format in Predicting Intervention Outcomes for Youth with Conduct Problems.Prevention science : the official journal of the Society for Prevention Research · 2018Trial
- Glucocorticoid Receptor (NR3C1) Gene Polymorphism Moderate Intervention Effects on the Developmental Trajectory of African-American Adolescent Alcohol Abuse.Prevention science : the official journal of the Society for Prevention Research · 2018Trial
- Developmental mediation of genetic variation in response to the Fast Track prevention program.Development and psychopathology · 2015Trial
- The German version of the highly sensitive child scale: Psychometric properties and identification of sensitivity groups.Current psychology (New Brunswick, N.J.) · 2026Article
- Gene-by-Environment Interaction Effects of Social Adversity on Externalizing Behavior in ABCD Youth.Behavior genetics · 2023Article
- Equipping Youth to Think and Act Responsibly: The Effectiveness of the "EQUIP for Educators" Program on Youths' Self-Serving Cognitive Distortions and School Bullying Perpetration.European journal of investigation in health, psychology and education · 2022Article
- CyberGenomics: Application of Behavioral Genetics in Cybersecurity.Behavioral sciences (Basel, Switzerland) · 2021Review
- New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2020Article
- Toward Tailored Interventions: Sympathetic and Parasympathetic Functioning Predicts Responses to an Intervention for Conduct Problems Delivered in Two Formats.Prevention science : the official journal of the Society for Prevention Research · 2019Article
- Developmental Change in Adolescent Delinquency: Modeling Time-Varying Effects of a Preventative Intervention and GABRA2 Halpotype Linked to Alcohol Use.Journal of youth and adolescence · 2019Article
- Vantage sensitivity: a framework for individual differences in response to psychological intervention.Social psychiatry and psychiatric epidemiology · 2018Review
- Post-GWAS in Psychiatric Genetics: A Developmental Perspective on the "Other" Next Steps.Genes, brain, and behavior · 2018Review
- Associations between alcohol dehydrogenase genes and alcohol use across early and middle adolescence: Moderation × Preventive intervention.Development and psychopathology · 2018Article
- Commentary for Special Issue of Prevention Science "Using Genetics in Prevention: Science Fiction or Science Fact?"Prevention science : the official journal of the Society for Prevention Research · 2018Article
- Maltreatment, the Oxytocin Receptor Gene, and Conduct Problems Among Male and Female Teenagers.Frontiers in human neuroscience · 2018Article
- New Clinically Relevant Findings about Violence by People with Schizophrenia.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2017Review
- Genetic influences on adolescent behavior.Neuroscience and biobehavioral reviews · 2016Review
- Differential susceptibility to environmental influences: Interactions between child temperament and parenting in adolescent alcohol use.Development and psychopathology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
Early interventions are a preferred method for addressing behavioral problems in high-risk children, but often have only modest effects. Identifying sources of variation in intervention effects can suggest means to improve efficiency. One potential source of such variation is the genome. We conducted a genetic analysis of the Fast Track randomized control trial, a 10-year-long intervention to prevent high-risk kindergarteners from developing adult externalizing problems including substance abuse and antisocial behavior. We tested whether variants of the glucocorticoid receptor gene NR3C1 were associated with differences in response to the Fast Track intervention. We found that in European-American children, a variant of NR3C1 identified by the single-nucleotide polymorphism rs10482672 was associated with increased risk for externalizing psychopathology in control group children and decreased risk for externalizing psychopathology in intervention group children. Variation in NR3C1 measured in this study was not associated with differential intervention response in African-American children. We discuss implications for efforts to prevent externalizing problems in high-risk children and for public policy in the genomic era.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.