ArticleJournal of dentistry (Shiraz, Iran)2015
The Effect of Thyroid Hormone, Prostaglandin E2, and Calcium Gluconate on Orthodontic Tooth Movement and Root Resorption in Rats.
Article in Journal of dentistry (Shiraz, Iran), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 34 citations in OpenAlex.
- Comparative evaluation of oral misoprostol and low-level laser therapy in orthodontic tooth movement in a rat model.BMC oral health · 2026Article
- The Therapeutic Approaches Dealing with Malocclusion Type III-Narrative Review.Life (Basel, Switzerland) · 2025Review
- Comparative Analysis of Early Class III Malocclusion Treatments-A Systematic Review and Meta-Analysis.Children (Basel, Switzerland) · 2025Review
- Impact of concentrated growth factor (CGF) injection on acceleration of orthodontic tooth movement in rabbits.BMC oral health · 2024Article
- Medications and Orthodontic Tooth Movement: What Accelerates and Diminishes Tooth Movement?Cureus · 2024Review
- Functional Biomaterials for Local Control of Orthodontic Tooth Movement.Journal of functional biomaterials · 2023Review
- Effects of vitamin D deficiency on the rate of orthodontic tooth movement: An animal study.The Saudi dental journal · 2022Article
- Effect of Topical PTH 1-34 Functionalized to BiogranMaterials (Basel, Switzerland) · 2021Article
- Intrinsic Hormone-Like Molecules and External Root Resorption During Orthodontic Tooth Movement. A Systematic Review and Meta-Analysis in PreclinicalFrontiers in physiology · 2018Article
- Analysis ofCell journalArticle
- [Local administration of prostaglandins to accelerate the orthodontic movement. A literature review].Revista cientifica odontologica (Universidad Cientifica del Sur)Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
statement of the problemA major objective of investigators is to clarify the role of metabolites in achievement of maximum tooth movement with minimal root damage during orthodontic tooth movement (OTM). PURPOSE: The aim of this study was to determine the effect of administration of thyroid hormone, prostaglandin E2, and calcium on orthodontic tooth movement and root resorption in rats. MATERIALS AND
methodSixty four male Wistar rats were randomly divided into 8 groups of eight rats each: 1- 20µg/kg thyroxine was injected in traperitoneally after installation of the orthodontic appliance. 2- 0.1 ml of 1 mg/ml prostaglandin E2 was injected submucosally. 3- 10% (200 mg/kg) calcium gluconate was injected. 4- Prostaglandin E2 was injected submucosally and 10% calcium was injected intraperitoneally. 5- Thyroxine was injected intraperitoneally and prostaglandin E2 was injected submucosally. 6- 20µg/kg thyroxine with calcium was injected. 7- Prostaglandin E2 was injected submucosally with calcium and thyroxine. 8- Distilled water was used in control group. The orthodontic appliances comprised of a NiTi closed coil were posteriorly connected to the right first molar and anteriorly to the upper right incisor. OTM was measured with a feeler gauge. The mid-mesial root of the first molar and the adjacent tissues were histologically evaluated. The Data were analyzed by one-way ANOVA and Student-Newman-Keuls test.
resultsThe highest mean OTM was observed in the thyroxine and prostaglandin E2 group (Mean±SD = 0.7375±0.1359 mm) that was significantly different (p< 0.05). A significant difference (p< 0.05) in root resorption was observed between the prostaglandin E2 (0.0192±0.0198 mm(2)) and the other groups.
conclusionIt seems that the combination of thyroxine and prostaglandin E2, with a synergistic effect, would decrease the root resorption and increase the rate of orthodontic tooth movement in rats.
Indexed as
Identifiers
26106633PMC4476115W1961393689What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.