Immunohistochemical Expression of Mast Cell in Oral Reactive Lesions.

Setareh Shojaei, Shokoofeh Jamshidi, Ghodratollah Roshanaei, Shirin Modabbernia, Bahman Farzin

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Article in Journal of dentistry (Shiraz, Iran), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 authors.

Setareh ShojaeiDept. of Oral and Maxillofacial Pathology, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran;

Shokoofeh JamshidiDental Research Center, Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran;

Ghodratollah RoshanaeiModeling of Noncommunicable Diseases Research Center, Dept. of Biostatistics and Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran;

Shirin ModabberniaPostgraduate Student, Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran;

Bahman FarzinGeneral Dentist, Private Practice, Hamadan, Iran;

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

statement of the problemSoft tissue reactive lesions are the most common lesions of the oral cavity. Although many studies have shown the interaction of mast cells with fibroblasts and their participation in fibrosis, the role of mast cells in these lesions is not well understood. PURPOSE: The aim of this study was to evaluate the mast cells (MCs) count in oral soft-tissue reactive lesions including peripheral giant cell granuloma (PGCG), peripheral ossifying fibroma (POF), irritation fibroma (IF) and normal oral mucosa. MATERIALS AND

methodIn this cross-sectional study, 50 samples including IF, PGCG, POF (14 cases for each group) and 8 cases of normal oral mucosa were stained with tryptase antibody through immunohistochemistry. The number of mast cells was counted in 5HPF containing maximum counts for each section stained with tryptase. Statistical analysis including Chi-square test and Tukey test with a significance level of 0.05 were considered.

resultsThe number of MCs was found to have increased in reactive lesions compared with normal oral mucosa. MCs count in the POF group was higher than the others.

conclusionThese findings suggest a possible role of mast cells in the pathogenesis of reactive oral lesions and induction of fibrous tissues. Chemical mediators released from mast cells might influence other cells, especially fibroblasts, to induce fibrosis.

Indexed as

LesionMast CellReactiveTryptase

Identifiers

PMID26106629

PMCPMC4476118

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