Evidence map›Paper›PMID 26106613›Full record

ArticleBioMed research international2015

Use of Contrast-Enhanced Ultrasound to Study Relationship between Serum Uric Acid and Renal Microvascular Perfusion in Diabetic Kidney Disease.

Ling Wang, Jia-Fen Cheng, Li-Ping Sun, Ya-Xiang Song, Le-Hang Guo, Jun-Mei Xu, Tian-Fu Wu, Chandra Mohan, Ai Peng, Hui-Xiong Xu and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. [The research and application advances of medical imaging techniques in early renal function assessment of chronic kidney disease].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2019
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Ling WangDepartment of Nephrology and Rheumatology, Shanghai Tenth People's Hospital, Tongji University, No. 301 Yanchangzhong Road, Zhabei District, Shanghai 200072, China.
Jia-Fen ChengDepartment of Nephrology and Rheumatology, Shanghai Tenth People's Hospital, Tongji University, No. 301 Yanchangzhong Road, Zhabei District, Shanghai 200072, China.
Li-Ping SunDepartment of Ultrasound in Medicine, Shanghai Tenth People's Hospital, Tongji University, No. 301 Yanchangzhong Road, Zhabei District, Shanghai 200072, China.
Ya-Xiang SongDepartment of Nephrology and Rheumatology, Shanghai Tenth People's Hospital, Tongji University, No. 301 Yanchangzhong Road, Zhabei District, Shanghai 200072, China.
Le-Hang GuoDepartment of Ultrasound in Medicine, Shanghai Tenth People's Hospital, Tongji University, No. 301 Yanchangzhong Road, Zhabei District, Shanghai 200072, China.ORCID 0000-0002-5685-1280
Jun-Mei XuDepartment of Ultrasound in Medicine, Shanghai Tenth People's Hospital, Tongji University, No. 301 Yanchangzhong Road, Zhabei District, Shanghai 200072, China.
Tian-Fu WuDepartment of Biomedical Engineering, University of Houston, 3605 Cullen Boulevard, Houston, TX 77204, USA.
Chandra MohanDepartment of Biomedical Engineering, University of Houston, 3605 Cullen Boulevard, Houston, TX 77204, USA.
Ai PengDepartment of Nephrology and Rheumatology, Shanghai Tenth People's Hospital, Tongji University, No. 301 Yanchangzhong Road, Zhabei District, Shanghai 200072, China.
Hui-Xiong XuDepartment of Ultrasound in Medicine, Shanghai Tenth People's Hospital, Tongji University, No. 301 Yanchangzhong Road, Zhabei District, Shanghai 200072, China.ORCID 0000-0001-8158-2265
Xin-Ying LiuDepartment of Nephrology and Rheumatology, Shanghai Tenth People's Hospital, Tongji University, No. 301 Yanchangzhong Road, Zhabei District, Shanghai 200072, China.
Tongji University · CNUniversity of Houston · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the relationship between uric acid and renal microvascular perfusion in diabetic kidney disease (DKD) using contrast-enhanced ultrasound (CEUS) method. MATERIALS AND

methods79 DKD patients and 26 healthy volunteers were enrolled. Renal function and urine protein markers were tested. DKD patients were subdivided into two groups including a normal serum uric acid (SUA) group and a high SUA group. Contrast-enhanced ultrasound (CEUS) was performed, and low acoustic power contrast-specific imaging was used for quantitative analysis.

resultsNormal controls (NCs) had the highest levels of AUC, AUC1, and AUC2. Compared to the normal SUA DKD group, high SUA DKD patients had significantly higher IMAX, AUC, and AUC1 (P < 0.05). DKD patients with low urinary uric acid (UUA) excretion had significantly higher AUC2 compared to DKD patients with normal UUA (P < 0.05).

conclusionHyperuricemia in DKD patients was associated with a renal ultrasound image suggestive of microvascular hyperperfusion. The CEUS parameter AUC1 holds promise as an indicator for renal microvascular hyperperfusion, while AUC2 might be a useful indicator of declining glomerular filtration rate in DKD patients with decreased excretion of uric acid.

Indexed as

Contrast MediaDiabetic NephropathiesFemaleHumansKidneyMaleMiddle AgedRisk FactorsUltrasonographyUric AcidContrast MediaUric Acid

Identifiers

PMID26106613
PMCPMC4464846
OpenAlexW1581636686

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.