ArticleFrontiers in bioengineering and biotechnology2015
3D Printing of Octacalcium Phosphate Bone Substitutes.
Article in Frontiers in bioengineering and biotechnology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03076138 (The Clinical Trial of the Safety and Efficacy of the Medical Device "Bone Substitute Based on Octacalcium Phosphate and Biologically Active Nucleic Acids for Bone Tissue Regeneration"), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Clinical Trial of the Safety and Efficacy of the Medical Device "Bone Substitute Based on Octacalcium Phosphate and Biologically Active Nucleic Acids for Bone Tissue Regeneration" (Nucleostim-VEGF)
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- 3D Printing of Calcium Phosphate Ceramics for Bone Tissue Engineering and Drug Delivery.Annals of biomedical engineering · 2017Pooled it
- Histological Study of a Novel 3D-Printed Hydroxyapatite/PLGA Bone Graft in the Regeneration of Critical-Sized Long Bone Defects.Bioengineering (Basel, Switzerland) · 2026Article
- Bone regenerative efficacy of binder-jet fabricated hydroxyapatite granules with and without biomimetic octacalcium phosphate-coated modification in a rat critical-sized calvarial defect model.Regenerative biomaterials · 2026Article
- Three Dimensionally Printed Octacalcium Phosphate via Binder Jetting for Use in Bone Grafting Applications.International journal of molecular sciences · 2025Article
- Enhanced osteogenic capacity of octacalcium phosphate involving adsorption of stromal-derived factor-1 in a standardized defect of a rat femur.Journal of materials science. Materials in medicine · 2025Article
- Article
- 3D Printed Gene-Activated Sodium Alginate Hydrogel Scaffolds.Gels (Basel, Switzerland) · 2022Article
- Fabrication and characterization of PHEMA-gelatin scaffold enriched with graphene oxide for bone tissue engineering.Journal of orthopaedic surgery and research · 2022Article
- Advances in 3D Printing for Tissue Engineering.Materials (Basel, Switzerland) · 2021Review
- Additive Manufacturing of Material Scaffolds for Bone Regeneration: Toward Application in the Clinics.Advanced functional materials · 2021Article
- Warp-Knitted Spacer Fabrics: A Versatile Platform to Generate Fiber-Reinforced Hydrogels for 3D Tissue Engineering.Materials (Basel, Switzerland) · 2020Article
- 3D Printed Gene-activated Octacalcium Phosphate Implants for Large Bone Defects Engineering.International journal of bioprinting · 2020Article
- The Injectable Woven Bone-Like Hydrogel to Perform Alveolar Ridge Preservation With Adapted Remodeling Performance After Tooth Extraction.Frontiers in bioengineering and biotechnology · 2020Article
- Recent advances in biomaterials for 3D scaffolds: A review.Bioactive materials · 2019Article
- The Applications of 3D Printing for Craniofacial Tissue Engineering.Micromachines · 2019Review
- Additive Manufacturing for Guided Bone Regeneration: A Perspective for Alveolar Ridge Augmentation.International journal of molecular sciences · 2018Review
- Recent Advances in Biomaterials for 3D Printing and Tissue Engineering.Journal of functional biomaterials · 2018Review
- Designing Biomaterials for 3D Printing.ACS biomaterials science & engineering · 2016Article
- 3D printing of mineral-polymer bone substitutes based on sodium alginate and calcium phosphate.Beilstein journal of nanotechnology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biocompatible calcium phosphate ceramic grafts are able of supporting new bone formation in appropriate environment. The major limitation of these materials usage for medical implants is the absence of accessible methods for their patient-specific fabrication. 3D printing methodology is an excellent approach to overcome the limitation supporting effective and fast fabrication of individual complex bone substitutes. Here, we proposed a relatively simple route for 3D printing of octacalcium phosphates (OCP) in complexly shaped structures by the combination of inkjet printing with post-treatment methodology. The printed OCP blocks were further implanted in the developed cranial bone defect followed by histological evaluation. The obtained result confirmed the potential of the developed OCP bone substitutes, which allowed 2.5-time reducing of defect's diameter at 6.5 months in a region where native bone repair is extremely inefficient.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.