Evidence map›Paper›PMID 26106579›Full record

ArticleEpilepsy & behavior case reports2015

A case study of voltage-gated potassium channel antibody-related limbic encephalitis with PET/MRI findings.

Brian K Day, Lawrence Eisenman, Joseph Black, Luigi Maccotta, R Edward Hogan

Open access · goldAbstract readCase Reports
In one paragraph

Article in Epilepsy & behavior case reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Brian K DayDepartment of Neurology, Washington University in St. Louis, Campus Box 8111, 660 South Euclid Avenue, St. Louis, MO 63110, USA.
Lawrence EisenmanDepartment of Neurology, Washington University in St. Louis, Campus Box 8111, 660 South Euclid Avenue, St. Louis, MO 63110, USA.
Joseph BlackDepartment of Neurology, Washington University in St. Louis, Campus Box 8111, 660 South Euclid Avenue, St. Louis, MO 63110, USA.
Luigi MaccottaDepartment of Neurology, Washington University in St. Louis, Campus Box 8111, 660 South Euclid Avenue, St. Louis, MO 63110, USA.
R Edward HoganDepartment of Neurology, Washington University in St. Louis, Campus Box 8111, 660 South Euclid Avenue, St. Louis, MO 63110, USA.
Washington University in St. Louis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Preclinical and clinical studies have demonstrated the significance of inflammation and autoantibodies in epilepsy, and the use of immunotherapies in certain situations has become an established practice. Temporal lobe epilepsy can follow paraneoplastic or nonparaneoplastic limbic encephalitis associated with antibodies directed against brain antigens. Here, we focus on a patient with worsening confusion and temporal lobe seizures despite treatment with antiepileptic medications. Serial brain MRIs did not conclusively reveal structural abnormalities, so the patient underwent brain PET/MRI to simultaneously evaluate brain structure and function, revealing bitemporal abnormalities. The patient was diagnosed with voltage-gated potassium channel antibody-related limbic encephalitis based on clinical presentation, imaging findings, and antibody testing. Treatment included the addition of a second antiepileptic agent and oral steroids. His seizures and cognitive deficits improved and stabilized.

Indexed as

Autoimmune epilepsyLimbic encephalitisMagnetic resonance imagingPET/MRIPositron emission tomographyVoltage-gated potassium channel

Identifiers

PMID26106579
PMCPMC4475784
OpenAlexW580256426

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.