Evidence map›Paper›PMID 26106568›Full record

ArticleNeuroImage. Clinical2015

Altered resting-state network connectivity in stroke patients with and without apraxia of speech.

Anneliese B New, Donald A Robin, Amy L Parkinson, Joseph R Duffy, Malcom R McNeil, Olivier Piguet, Michael Hornberger, Cathy J Price, Simon B Eickhoff, Kirrie J Ballard

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 62 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 4 countries.

Anneliese B NewResearch Imaging Institute, University of Texas Health Science Center San Antonio, San Antonio, TX, USA.
Donald A RobinResearch Imaging Institute, University of Texas Health Science Center San Antonio, San Antonio, TX, USA ; Department of Neurology, University of Texas Health Science Center San Antonio, San Antonio, TX, USA ; Joint Program in Biomedical Engineering, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA ; Honors College, University of Texas, San Antonio, TX, USA.
Amy L ParkinsonResearch Imaging Institute, University of Texas Health Science Center San Antonio, San Antonio, TX, USA ; Department of Neurology, University of Texas Health Science Center San Antonio, San Antonio, TX, USA.
Joseph R DuffyMayo Clinic, Rochester, MN, USA.
Malcom R McNeilUniversity of Pittsburgh and Veterans Administration, Pittsburgh Healthcare System, Pittsburgh, PA, USA.
Olivier PiguetNeuroscience Research Australia and University of New South Wales, Randwick, NSW,Australia.
Michael HornbergerNeuroscience Research Australia and University of New South Wales, Randwick, NSW,Australia.
Cathy J PriceWellcome Trust Centre for Neuroimaging, University College London, London, UK.
Simon B EickhoffInstitute of Neuroscience and Medicine (INM-1), Research Center Julich, Julich, Germany ; Department of Clinical Neuroscience and Medical Psychology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Kirrie J BallardNeuroscience Research Australia and University of New South Wales, Randwick, NSW,Australia ; Faculty of Health Sciences, The University of Sydney, Sydney, Australia.
The University of Texas Health Science Center at San Antonio · USUNSW Sydney · AUForschungszentrum Jülich · DEMayo Clinic in Arizona · USThe University of Sydney · AUUniversity of Pittsburgh · USWellcome Centre for Human Neuroimaging · GB

Funding

Wellcome Trust 091593Wellcome Trust 097720
6 · The paper itself

Abstract

Motor speech disorders, including apraxia of speech (AOS), account for over 50% of the communication disorders following stroke. Given its prevalence and impact, and the need to understand its neural mechanisms, we used resting state functional MRI to examine functional connectivity within a network of regions previously hypothesized as being associated with AOS (bilateral anterior insula (aINS), inferior frontal gyrus (IFG), and ventral premotor cortex (PM)) in a group of 32 left hemisphere stroke patients and 18 healthy, age-matched controls. Two expert clinicians rated severity of AOS, dysarthria and nonverbal oral apraxia of the patients. Fifteen individuals were categorized as AOS and 17 were AOS-absent. Comparison of connectivity in patients with and without AOS demonstrated that AOS patients had reduced connectivity between bilateral PM, and this reduction correlated with the severity of AOS impairment. In addition, AOS patients had negative connectivity between the left PM and right aINS and this effect decreased with increasing severity of non-verbal oral apraxia. These results highlight left PM involvement in AOS, begin to differentiate its neural mechanisms from those of other motor impairments following stroke, and help inform us of the neural mechanisms driving differences in speech motor planning and programming impairment following stroke.

Indexed as

AgedApraxiasCerebral CortexConnectomeFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNerve NetStrokeApraxia of speechNetwork connectivityResting-state fMRIStroke

Identifiers

PMID26106568
PMCPMC4473263
OpenAlexW1811518384

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.