ArticleNeuroImage. Clinical2015
Longitudinal gray matter contraction in three variants of primary progressive aphasia: A tenser-based morphometry study.
Article in NeuroImage. Clinical, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
- Cortical microstructure in familial frontotemporal dementia associated with MAPT, GRN, and C9orf72 pathogenic variants: Looking beyond atrophy.The journal of prevention of Alzheimer's disease · 2025Article
- Multiparametric MRI-based biomarkers in the non-fluent and semantic variants of primary progressive aphasia.Journal of neurology · 2025Article
- Impaired semantic control in the logopenic variant of primary progressive aphasia.Brain communications · 2025Article
- Symptom-based staging for logopenic variant primary progressive aphasia.European journal of neurology · 2024Article
- Longitudinal flortaucipir, metabolism and volume differ between phonetic and prosodic speech apraxia.Brain : a journal of neurology · 2024Article
- Longitudinal volumetric changes in amygdala subregions in frontotemporal dementia.Journal of neurology · 2024Article
- Breakdown of category-specific word representations in a brain-constrained neurocomputational model of semantic dementia.Scientific reports · 2023Article
- The right hemisphere's capacity for language: evidence from primary progressive aphasia.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Microglial activation in the frontal cortex predicts cognitive decline in frontotemporal dementia.Brain : a journal of neurology · 2023Article
- Association of cortical and subcortical microstructure with disease severity: impact on cognitive decline and language impairments in frontotemporal lobar degeneration.Alzheimer's research & therapy · 2023Article
- Symptom-led staging for primary progressive aphasia.medRxiv : the preprint server for health sciences · 2023Article
- Observational
- Functional connectivity to the premotor cortex maps onto longitudinal brain neurodegeneration in progressive apraxia of speech.Neurobiology of aging · 2022Article
- Right temporal degeneration and socioemotional semantics: semantic behavioural variant frontotemporal dementia.Brain : a journal of neurology · 2022Article
- Understanding the multidimensional cognitive deficits of logopenic variant primary progressive aphasia.Brain : a journal of neurology · 2022Review
- Auditory Verb Generation Performance Patterns Dissociate Variants of Primary Progressive Aphasia.Frontiers in psychology · 2022Article
- Longitudinal Changes in Cognition, Behaviours, and Functional Abilities in the Three Main Variants of Primary Progressive Aphasia: A Literature Review.Brain sciences · 2021Review
- Neuroimaging in Frontotemporal Dementia: Heterogeneity and Relationships with Underlying Neuropathology.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Review
- Neuroimaging in Frontotemporal Lobar Degeneration: Research and Clinical Utility.Advances in experimental medicine and biology · 2021Review
- Diagnostic Assessment in Primary Progressive Aphasia: An Illustrative Case Example.American journal of speech-language pathology · 2020Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
The present study investigated the pattern of longitudinal changes in cognition and anatomy in three variants of primary progressive aphasia (PPA). Eight patients with the non-fluent variant of PPA (nfvPPA), 13 patients with the semantic variant (svPPA), seven patients with the logopenic variant (lvPPA), and 29 age-matched, neurologically healthy controls were included in the study. All participants underwent longitudinal MRI, neuropsychological and language testing at baseline and at a 1-year follow-up. Tenser-based morphometry (TBM) was applied to T1-weighted MRI images in order to map the progression of gray and white matter atrophy over a 1-year period. Results showed that each patient group was characterized by a specific pattern of cognitive and anatomical changes. Specifically, nfvPPA patients showed gray matter atrophy progression in the left frontal and subcortical areas as well as a decline in motor speech and executive functions; svPPA patients presented atrophy progression in the medial and lateral temporal lobe and decline in semantic memory abilities; and lvPPA patients showed atrophy progression in lateral/posterior temporal and medial parietal regions with a decline in memory, sentence repetition and calculations. In addition, in all three variants, the white matter fibers underlying the abovementioned cortical areas underwent significant volume contraction over a 1-year period. Overall, these results indicate that the three PPA variants present distinct patterns of neuroanatomical contraction, which reflect their clinical and cognitive progression.
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