ArticleNeuroImage. Clinical2015
Brain activation during self- and other-reflection in bipolar disorder with a history of psychosis: Comparison to schizophrenia.
Article in NeuroImage. Clinical, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Functional Neuroimaging Meta-Analysis of Self-Related Processing in Schizophrenia.Frontiers in neurology · 2019Pooled it
- Brain neuromarkers predict self- and other-related mentalizing across adult, clinical, and developmental samples.Nature communications · 2026Article
- Deviations From Normative Functioning Underlying Emotional Episodic Memory Revealed Cross-Scale Neurodiverse Alterations Linked to Affective Symptoms in Distinct Psychiatric Disorders.Biological psychiatry global open science · 2025Article
- Distinguished Frontal White Matter Abnormalities Between Psychotic and Nonpsychotic Bipolar Disorders in a Pilot Study.Brain sciences · 2025Article
- Irony comprehension in first-degree relatives of patients with bipolar affective disorder - a preliminary fMRI study.Frontiers in psychiatry · 2025Article
- A functional neuroimaging study of self-other processing alterations in atypical developmental trajectories of psychotic-like experiences.Scientific reports · 2022Article
- Increased Global-Brain Functional Connectivity Is Associated with Dyslipidemia and Cognitive Impairment in First-Episode, Drug-Naive Patients with Bipolar Disorder.Neural plasticity · 2021Article
- Dissociation Pattern in Default-Mode Network Homogeneity in Drug-Naive Bipolar Disorder.Frontiers in psychiatry · 2021Article
- Hyperactivation of Posterior Default Mode Network During Self-Referential Processing in Children at Familial High-Risk for Psychosis.Frontiers in psychiatry · 2021Article
- Neuroplasticity Improves Bipolar Disorder: A Review.Cureus · 2020Review
- Article
- Insight in schizophrenia spectrum disorders: relationship with behavior, mood and perceived quality of life, underlying causes and emerging treatments.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2018Article
- Shared and Specific Intrinsic Functional Connectivity Patterns in Unmedicated Bipolar Disorder and Major Depressive Disorder.Scientific reports · 2017Article
- The metabolic basis of cognitive insight in psychosis: A positron emission tomography study.PloS one · 2017Article
- Brain structure, function, and neurochemistry in schizophrenia and bipolar disorder-a systematic review of the magnetic resonance neuroimaging literature.NPJ schizophrenia · 2017Article
- Metacognitive impairment in active cocaine use disorder is associated with individual differences in brain structure.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2016Article
- Recent Neurobiological Insights into the Concept of Insight in Psychosis.Indian journal of psychological medicineArticle
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesReflecting on the self and on others activates specific brain areas and contributes to metacognition and social cognition. The aim of the current study is to investigate brain activation during self- and other-reflection in patients with bipolar disorder (BD). In addition, we examined whether potential abnormal brain activation in BD patients could distinguish BD from patients with schizophrenia (SZ).
methodsDuring functional magnetic resonance imaging (fMRI), 17 BD patients, 17 SZ patients and 21 healthy controls (HCs) performed a self-reflection task. The task consisted of sentences divided into three conditions: self-reflection, other-reflection and semantic control.
resultsBD patients showed less activation in the posterior cingulate cortex (PCC) extending to the precuneus during other-reflection compared to HCs (p = 0.028 FWE corrected on cluster-level within the regions of interest). In SZ patients, the level of activation in this area was in between BD patients and HCs, with no significant differences between patients with SZ and BD. There were no group differences in brain activation during self-reflection. Moreover, there was a positive correlation between the PCC/precuneus activation during other-reflection and cognitive insight in SZ patients, but not in BD patients.
conclusionsBD patients showed less activation in the PCC/precuneus during other-reflection. This may support an account of impaired integration of emotion and memory (evaluation of past and current other-related information) in BD patients. Correlation differences of the PCC/precuneus activation with the cognitive insight in patients with BD and SZ might reflect an important difference between these disorders, which may help to further explore potentially distinguishing markers.
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