ArticleNeuroImage. Clinical2015
Increased cortico-striatal connectivity during motor practice contributes to the consolidation of motor memory in writer's cramp patients.
Article in NeuroImage. Clinical, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Functional segregation in Parkinson's disease.Science advances · 2026Article
- Brain network pathophysiology in dystonia.Dystonia (Lausanne, Switzerland) · 2025Article
- Investigation of the posterior parietal cortex to ventral premotor connection in writer's cramp using transcranial magnetic stimulation.Experimental brain research · 2022Article
- Motor learning deficits in cervical dystonia point to defective basal ganglia circuitry.Scientific reports · 2021Article
- Functional Neural Networks in Writer's Cramp as Determined by Graph-Theoretical Analysis.Frontiers in neurology · 2021Article
- Current Opinions and Areas of Consensus on the Role of the Cerebellum in Dystonia.Cerebellum (London, England) · 2017Article
- Impairment of a parieto-premotor network specialized for handwriting in writer's cramp.Human brain mapping · 2016Article
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Authors and funding
14 authors.
Funding
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Abstract
Sensorimotor representations of movements are created in the sensorimotor network through repeated practice to support successful and effortless performance. Writer's cramp (WC) is a disorder acquired through extensive practice of finger movements, and it is likely associated with the abnormal acquisition of sensorimotor representations. We investigated (i) the activation and connectivity changes in the brain network supporting the acquisition of sensorimotor representations of finger sequences in patients with WC and (ii) the link between these changes and consolidation of motor performance 24 h after the initial practice. Twenty-two patients with WC and 22 age-matched healthy volunteers practiced a complex sequence with the right (pathological) hand during functional MRI recording. Speed and accuracy were measured immediately before and after practice (day 1) and 24 h after practice (day 2). The two groups reached equivalent motor performance on day 1 and day 2. During motor practice, patients with WC had (i) reduced hippocampal activation and hippocampal-striatal functional connectivity; and (ii) overactivation of premotor-striatal areas, whose connectivity correlated with motor performance after consolidation. These results suggest that patients with WC use alternative networks to reach equiperformance in the acquisition of new motor memories.
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