ArticleNeuroImage. Clinical2015
Conflict anticipation in alcohol dependence - A model-based fMRI study of stop signal task.
Article in NeuroImage. Clinical, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 3 of them syntheses that pooled it.
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Who cites it
48 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Common and separable neural alterations in substance use disorders: A coordinate-based meta-analyses of functional neuroimaging studies in humans.Human brain mapping · 2020Pooled it
- Cerebellar Contributions to Proactive and Reactive Control in the Stop Signal Task: A Systematic Review and Meta-Analysis of Functional Magnetic Resonance Imaging Studies.Neuropsychology review · 2020Pooled it
- Neuroimaging Impaired Response Inhibition and Salience Attribution in Human Drug Addiction: A Systematic Review.Neuron · 2018Pooled it
- Slower adaptation of control strategies in individuals with high impulsive tendencies.Scientific reports · 2021Trial
- Neural affective mechanisms associated with treatment responsiveness in veterans with PTSD and comorbid alcohol use disorder.Psychiatry research. Neuroimaging · 2020Trial
- Naltrexone differentially modulates the neural correlates of motor impulse control in abstinent alcohol-dependent and polysubstance-dependent individuals.The European journal of neuroscience · 2019Trial
- Social Mistreatment Effect on Alcohol Misuse Trajectories Is Moderated by Subcortical Network Activation During Error Processing.Addiction biology · 2026Article
- Clinical value of predicting relapse within 3 months in alcohol-dependent patients using fNIRS in verbal fluency task.Scientific reports · 2025Article
- Social context and drug cues modulate inhibitory control in cocaine addiction: involvement of the STN evidenced through functional MRI.Molecular psychiatry · 2024Article
- Drinking severity mediates the relationship between hypothalamic connectivity and rule-breaking/intrusive behavior differently in young women and men: an exploratory study.Quantitative imaging in medicine and surgery · 2024Article
- Motivational context and neurocomputation of stop expectation moderate early attention responses supporting proactive inhibitory control.Frontiers in human neuroscience · 2024Article
- Brain volumes in alcohol use disorder: Do females and males differ? A whole-brain magnetic resonance imaging mega-analysis.Human brain mapping · 2023Article
- Effects of combined physical and cognitive training on executive function of adolescent shooting athletes: A functional near-infrared spectroscopy study.Sports medicine and health science · 2023Article
- Binge drinking is associated with higher cortisol and lower hippocampal and prefrontal gray matter volume: Prospective association with future alcohol intake.Neurobiology of stress · 2023Article
- Increased EEG gamma power under exposure to drug-related cues: a translational index for cue-elicited craving in METH-dependent individuals.BMC psychiatry · 2023Article
- Alcohol-induced deficits in reactive control of response selection and inhibition are counteracted by a seemingly paradox increase in proactive control.Scientific reports · 2023Article
- Altered prefrontal signaling during inhibitory control in a salient drug context in cocaine use disorder.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- The Neural Signature of Impaired Inhibitory Control in Individuals with Heroin Use Disorder.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Patients with Methamphetamine Use Disorder Show Highly Utilized Proactive Inhibitory Control and Intact Reactive Inhibitory Control with Long-Term Abstinence.Brain sciences · 2022Article
- Statistical Nonparametric fMRI Maps in the Analysis of Response Inhibition in Abstinent Individuals with History of Alcohol Use Disorder.Behavioral sciences (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundOur previous work characterized altered cerebral activations during cognitive control in individuals with alcohol dependence (AD). A hallmark of cognitive control is the ability to anticipate changes and adjust behavior accordingly. Here, we employed a Bayesian model to describe trial-by-trial anticipation of the stop signal and modeled fMRI signals of conflict anticipation in a stop signal task. Our goal is to characterize the neural correlates of conflict anticipation and its relationship to response inhibition and alcohol consumption in AD.
methodsTwenty-four AD and 70 age and gender matched healthy control individuals (HC) participated in the study. fMRI data were pre-processed and modeled with SPM8. We modeled fMRI signals at trial onset with individual events parametrically modulated by estimated probability of the stop signal, p(Stop), and compared regional responses to conflict anticipation between AD and HC. To address the link to response inhibition, we regressed whole-brain responses to conflict anticipation against the stop signal reaction time (SSRT).
resultsCompared to HC (54/70), fewer AD (11/24) showed a significant sequential effect - a correlation between p(Stop) and RT during go trials - and the magnitude of sequential effect is diminished, suggesting a deficit in proactive control. Parametric analyses showed decreased learning rate and over-estimated prior mean of the stop signal in AD. In fMRI, both HC and AD responded to p(Stop) in bilateral inferior parietal cortex and anterior pre-supplementary motor area, although the magnitude of response increased in AD. In contrast, HC but not AD showed deactivation of the perigenual anterior cingulate cortex (pgACC). Furthermore, deactivation of the pgACC to increasing p(Stop) is positively correlated with the SSRT in HC but not AD. Recent alcohol consumption is correlated with increased activation of the thalamus and cerebellum in AD during conflict anticipation.
conclusionsThe current results highlight altered proactive control that may serve as an additional behavioral and neural marker of alcohol dependence.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.