ArticleNew microbes and new infections2015
Vitamin D receptor expression levels determine the severity and complexity of disease progression among leprosy reaction patients.
Article in New microbes and new infections, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 61 citations in OpenAlex.
- Autoantibodies and vitamin D in leprosy patients in the Brazilian Amazon.BMC infectious diseases · 2026Article
- Estimation of Serum Vitamin D Levels and Helminthic Coinfection in Patients with Type 2 Lepra Reactions and its Correlation with Severity of Type 2 Reactions: A Cross-Sectional Study.Indian dermatology online journal · 2025Article
- An Infectious Disease Mimicking Rheumatologic Disease in an Adolescent.Clinical pediatrics · 2025Article
- Vitamin B12 and D3 Levels in Leprosy Patients With or Without Deformity: A Cross-Sectional, Analytic Study.Cureus · 2025Article
- Influence of genetic variants of the vitamin D receptor on clinical profile in cirrhosis and hepatocellular carcinoma.Ecancermedicalscience · 2025Article
- Iron and vitamin D intake on a diet are able to modify the in vitro immune response to Mycobacterium leprae.Memorias do Instituto Oswaldo Cruz · 2024Article
- Association between serum level of vitamin D (25-hydroxyvitamin D) and plasma level of vitamin D receptor with bacteriological index in leprosy patients.Dermatology reports · 2023Article
- Article
- Undernutrition, food insecurity, and leprosy in North Gondar Zone, Ethiopia: A case-control study to identify infection risk factors associated with poverty.PLoS neglected tropical diseases · 2021Article
- Host-Related Laboratory Parameters for Leprosy Reactions.Frontiers in medicine · 2021Review
- Serum 25-hydroxyvitamin D level and vitamin D receptor (VDR) polymorphisms in patients infected withJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2020Article
- The Burden of Helminth Coinfections and Micronutrient Deficiencies in Patients with and without Leprosy Reactions: A Pilot Study in Minas Gerais, Brazil.The American journal of tropical medicine and hygiene · 2019Article
- Association of Fok1 VDR polymorphism with Vitamin D and its associated molecules in pulmonary tuberculosis patients and their household contacts.Scientific reports · 2019Article
- Vitamin D Receptor Gene Polymorphisms Are Associated With Leprosy in Southern Brazil.Frontiers in immunology · 2019Article
- VDR polymorphism, gene expression and vitamin D levels in leprosy patients from North Indian population.PLoS neglected tropical diseases · 2018Article
- Intrinsic activation of the vitamin D antimicrobial pathway by M. leprae infection is inhibited by type I IFN.PLoS neglected tropical diseases · 2018Article
- A Systematic Review of Immunological Studies of Erythema Nodosum Leprosum.Frontiers in immunology · 2017Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We studied the roles of vitamin D and its receptor, VDR, in the progression of leprosy. The majority of individuals with leprosy from Kolkata, India, with a type 1 or type 2 reaction have low levels of vitamin D3 in serum samples. Interestingly, individuals with a type 2 reaction associated with neuritis/erythema nodosum leprosum had very low VDR mRNA expression levels, ranging from 5% to 10%, compared to that of healthy control subjects; these patients also had a high bacilli index, ranging from 3+ to 5+. This is the first report to indicate that VDR expression levels may determine the complexity and severity of the progression of leprosy.
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