ArticleMiddle East journal of digestive diseases2015
Serological Evaluation of Celiac Disease in Children with Congenital Heart Defect; A Case Control Study.
Article in Middle East journal of digestive diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Isolated ventricular septal defect is not a risk factor for celiac disease: evidence from a large real-world data cohort of 493,382 children.Frontiers in pediatrics · 2026Article
- Frequency of seropositive celiac disease and hypothyroidism among children and adolescents with congenital heart disease: A case-control study.BMC pediatrics · 2024Article
- Celiac disease in children: Increasing prevalence and changing clinical presentations.Clinical and experimental pediatrics · 2021Article
- Cardiovascular involvement in celiac disease.World journal of cardiology · 2017Review
- Celiac disease in Iran: a systematic review and meta-analysis.Electronic physician · 2017Article
- Lithophagia as a clue for celiac disease: a case report and literature review.Gastroenterology and hepatology from bed to bench · 2017Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND Due to the increased prevalence of celiac disease in chromosomal anomalies and other congenital anomalies, this study was conducted to evaluate the seroprevalence of celiac disease (CD) in patients with congenital heart defects (CHD). METHODS This case-control study was done on 1002 children in two groups of CHD patients (n=402) and controls (n=600). The serum tissue transglutamianse (TTG) levels were investigated. The two groups were compared in terms of TTG IgA levels and p<0.05 was considered as the significant level. RESULTS The means of serum TTG IgA levels in children with CHD and the control groups were 19.17±46.67 and 7.77±10.02 u/mL respectively (p=0.001). After ANOVA analysis a significant difference between two cyanotic and acyanotic subgroups of cases and control groups was observed (p=0.000). The follow up tukey test showed only non-significant difference between the cyanotic and acyanotic cases. The frequency of TTG IgA with the consideration of 20 u/mL as cut-off point showed a significant association with groups (X2=28.31 and p=0.000). CONCLUSION According to the results the serum TTG IgA levels were significantly higher in patients with CHD than normal children and screening for CD in children with CHD is recommended.
Indexed as
Identifiers
26106470PMC4430799W2769125726What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.