ArticleOxidative medicine and cellular longevity2015
Quercetin Affects Erythropoiesis and Heart Mitochondrial Function in Mice.
Article in Oxidative medicine and cellular longevity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 29 citations in OpenAlex.
- Metabolic Stress Induced by Quercetin Enhances Dormancy and Persistence inAntibiotics (Basel, Switzerland) · 2025Article
- The multifaceted role of quercetin derived from its mitochondrial mechanism.Molecular and cellular biochemistry · 2024Review
- Neurotherapeutic Effects of Quercetin and Its Metabolite Compounds on Cognitive Impairment and Parkinson's Disease: An In Silico Study.European journal of drug metabolism and pharmacokinetics · 2023Article
- Computational Analysis on Antioxidant Activity of Four Characteristic Structural Units from Persimmon Tannin.Materials (Basel, Switzerland) · 2022Article
- Effects and Mechanisms of Taohong Siwu Decoction on the Prevention and Treatment of Myocardial Injury.Frontiers in pharmacology · 2022Review
- Biosystem Analysis of the Hypoxia Inducible Domain Family Member 2A: Implications in Cancer Biology.Genes · 2020Article
- Synergistic effects of quercetin and regular exercise on the recovery of spatial memory and reduction of parameters of oxidative stress in animal model of Alzheimer's disease.EXCLI journal · 2020Article
- Astaxanthin but not quercetin preserves mitochondrial integrity and function, ameliorates oxidative stress, and reduces heat-induced skeletal muscle injury.Journal of cellular physiology · 2019Article
- Theoretical Study of the Antioxidant Activity of Quercetin Oxidation Products.Frontiers in chemistry · 2019Article
- Effects ofBiology · 2018Article
- Natural Compounds as Occult Ototoxins? Ginkgo biloba Flavonoids Moderately Damage Lateral Line Hair Cells.Journal of the Association for Research in Otolaryngology : JARO · 2017Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Quercetin, a dietary flavonoid used as a food supplement, showed powerful antioxidant effects in different cellular models. However, recent in vitro and in vivo studies in mammals have suggested a prooxidant effect of quercetin and described an interaction with mitochondria causing an increase in O2 (∙-) production, a decrease in ATP levels, and impairment of respiratory chain in liver tissue. Therefore, because of its dual actions, we studied the effect of quercetin in vivo to analyze heart mitochondrial function and erythropoiesis. Mice were injected with 50 mg/kg of quercetin for 15 days. Treatment with quercetin decreased body weight, serum insulin, and ceruloplasmin levels as compared with untreated mice. Along with an impaired antioxidant capacity in plasma, quercetin-treated mice showed a significant delay on erythropoiesis progression. Heart mitochondrial function was also impaired displaying more protein oxidation and less activity for IV, respectively, than no-treated mice. In addition, a significant reduction in the protein expression levels of Mitofusin 2 and Voltage-Dependent Anion Carrier was observed. All these results suggest that quercetin affects erythropoiesis and mitochondrial function and then its potential use as a dietary supplement should be reexamined.
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