ArticleChemistry Central journal2015
Simultaneous extraction, optimization, and analysis of flavonoids and polyphenols from peach and pumpkin extracts using a TLC-densitometric method.
Article in Chemistry Central journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 58 citations in OpenAlex.
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- Pharmacognostic Evaluation, Chemical Characterization, and Antibacterial Activity ofPlants (Basel, Switzerland) · 2024Article
- Selective Encapsulation of the Polyphenols on Silk Fibroin Nanoparticles: Optimization Approaches.International journal of molecular sciences · 2023Article
- Valorization of Pumpkin Peel as a Source of Bioactive Compounds: Optimization of Heat- and Ultrasound-Assisted Extraction.Molecules (Basel, Switzerland) · 2023Article
- Response Surface Methodology Applied to the Optimization of the Preparation of Antioxidant and Antidiabetic Extracts fromEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Comparative In Vitro Antioxidant Capacity and Terpenoid Profiling of Pumpkin Fruit Pulps from a SerbianAntioxidants (Basel, Switzerland) · 2021Article
- Development ofFoods (Basel, Switzerland) · 2021Article
- Chitosan and glyceryl monooleate nanostructures containing gallic acid isolated from amla fruit: targeted delivery system.Heliyon · 2021Article
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- The Profile of Carotenoids and Other Bioactive Molecules in Various Pumpkin Fruits (Molecules (Basel, Switzerland) · 2019Article
- Extraction and Optimization of Potato Starch and Its Application as a Stabilizer in Yogurt Manufacturing.Foods (Basel, Switzerland) · 2018Article
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- A Rapid and Simple TLC-Densitometric Method for Assay of Clobetasol Propionate in Topical Solution.Molecules (Basel, Switzerland) · 2017Article
- Phytochemicals: Extraction, Isolation, and Identification of Bioactive Compounds from Plant Extracts.Plants (Basel, Switzerland) · 2017Review
- Apigenin enhances the cisplatin cytotoxic effect through p53-modulated apoptosis.Oncology letters · 2017Article
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe use of medicinal plants has been reported throughout human history. In the fight against illnesses, medicinal plants represent the primary health care system for 60 % of the world's population. Flavonoids are polyphenolic compounds with active anti-microbial properties; they are produced in plants as pigments. Quercetin, myricetin, and rutin are among the most well-known and prevalent flavonoids in plants, with an antioxidant activity capable of decreasing the oxidation of low density lipoproteins [LDLs]. To date, this research is the first of its kind to employ a coupled thin-layer chromatography (TLC) and a densitometric quantification method with a Box-Behnken design (BBD) response surface methodology (RSM) for optimization of ultrasonic-assisted extraction and determination of rutin and quercetin from peach and ellagic acid and myricetin from pumpkin fruits.
resultsThe effect of process variables (extraction temperature (°C), extraction power (%) and extraction time (min)) on ultrasound-assisted extraction (UAE) were examined by using BBD and RSM. TLC followed by Quantity-One™ (BioRad) image analysis as a simple and rapid method was used for identification and quantification of the compounds in complex mixtures. The results were consistent under optimal conditions among the experimental values and their predicted values. A mass spectrometry (MALDI-TOF MS) technique was also used to confirm the identity of the natural products in the TLC spots resolved.
conclusionThe results show that the coupled TLC-densitometric methods & BBD can be a very powerful approach to qualitative and quantitative analysis of; rutin and quercetin from peach extracts; and ellagic acid and myricetin contents from pumpkin extracts.
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