Evidence map›Paper›PMID 26106431›Full record

ReviewStem cells international2015

Mesenchymal Stem Cells and Cutaneous Wound Healing: Current Evidence and Future Potential.

M Isakson, C de Blacam, D Whelan, A McArdle, A J P Clover

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Stem cells international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04219657 (Comparison of Outcome of Mesenchymal Stem Cells And Skin Graft With Skin Graft In Management of Traumatic Heel Pad Injuries of Children), which is not on this map. Cited by 95 papers.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04219657 phase1completednot on this mapstarted 2016, after this paper: background citation

Comparison of Outcome of Mesenchymal Stem Cells And Skin Graft With Skin Graft In Management of Traumatic Heel Pad Injuries of Children

TypeinterventionalSponsorKing Edward Medical UniversityRan2016 to 2019Enrolled110ConditionsAccidental Wound, Heel Injury, Stem Cell TransplantArmsmesenchymal stem cell application
3 · Its place in the literature

Who cites it

95 citing papers in PubMed.

  1. Trial
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  8. Microenvironmental Modulation for Therapeutic Efficacy of Extracellular Vesicles.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  9. Review
  10. Mesenchymal Stem Cell Extract Promotes Skin Wound Healing.International journal of molecular sciences · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Review

35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

M IsaksonDepartment of Plastic and Reconstructive Surgery, Cork University Hospital, Cork, Ireland.
C de BlacamDepartment of Plastic and Reconstructive Surgery, Cork University Hospital, Cork, Ireland.
D WhelanCentre for Research in Vascular Biology, University College Cork, Cork, Ireland.
A McArdleDepartment of Plastic and Reconstructive Surgery, Cork University Hospital, Cork, Ireland.
A J P CloverDepartment of Plastic and Reconstructive Surgery, Cork University Hospital, Cork, Ireland ; Centre for Research in Vascular Biology, University College Cork, Cork, Ireland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human skin is a remarkable organ that sustains insult and injury throughout life. The ability of skin to expeditiously repair wounds is paramount to survival. With an aging global population, coupled with a rise in the prevalence of conditions such as diabetes, chronic wounds represent a significant biomedical burden. Mesenchymal stem cells (MSC), a progenitor cell population of the mesoderm lineage, have been shown to be significant mediators in inflammatory environments. Preclinical studies of MSC in various animal wound healing models point towards a putative therapy. This review examines the body of evidence suggesting that MSC accelerate wound healing in both clinical and preclinical studies and also the possible mechanisms controlling its efficacy. The delivery of a cellular therapy to the masses presents many challenges from a safety, ethical, and regulatory point of view. Some of the issues surrounding the introduction of MSC as a medicinal product are also delineated in this review.

Identifiers

PMID26106431
PMCPMC4461792

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.