ArticleStem cells international2015
A 3D Porous Gelatin-Alginate-Based-IPN Acts as an Efficient Promoter of Chondrogenesis from Human Adipose-Derived Stem Cells.
Article in Stem cells international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Review
- Characteristics of a novel photoinitiator aceanthrenequinone-initiated polymerization and cytocompatibility of its triggered polymer.Toxicology reports · 2022Article
- Advanced Hydrogels for Cartilage Tissue Engineering: Recent Progress and Future Directions.Polymers · 2021Review
- Angiogenic effects of cell therapy within a biomaterial scaffold in a rat hind limb ischemia model.Scientific reports · 2021Article
- A Critical Review on the Design, Manufacturing and Assessment of the Bone Scaffold for Large Bone Defects.Frontiers in bioengineering and biotechnology · 2021Review
- Release of the Non-Steroidal Anti-Inflammatory Drug Flufenamic Acid by Multiparticulate Delivery Systems Promotes Adipogenic Differentiation of Adipose-Derived Stem Cells.Materials (Basel, Switzerland) · 2020Article
- Article
- Gelatin-polysaccharide composite scaffolds for 3D cell culture and tissue engineering: Towards natural therapeutics.Bioengineering & translational medicine · 2019Review
- Histomorphometric and immunohistochemical evaluation of angiogenesis in ischemia by tissue engineering in rats: Role of mast cells.Veterinary research forum : an international quarterly journal · 2019Article
- Regenerative Engineering for Knee Osteoarthritis Treatment: Biomaterials and Cell-Based Technologies.Engineering (Beijing, China) · 2017Article
- Recent advances in hydrogels for cartilage tissue engineering.European cells & materials · 2017Review
- Adipose, Bone Marrow and Synovial Joint-Derived Mesenchymal Stem Cells for Cartilage Repair.Frontiers in genetics · 2016Review
- Calcium/Cobalt Alginate Beads as Functional Scaffolds for Cartilage Tissue Engineering.Stem cells international · 2016Article
- Stem cell origin differently affects bone tissue engineering strategies.Frontiers in physiology · 2015Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cartilage has limited regeneration potential. Thus, there is an imperative need to develop new strategies for cartilage tissue engineering (CTE) amenable for clinical use. Recent CTE approaches rely on optimal cell-scaffold interactions, which require a great deal of optimization. In this study we attempt to build a novel gelatin- (G-) alginate- (A-) polyacrylamide (PAA) 3D interpenetrating network (IPN) with superior performance in promoting chondrogenesis from human adipose-derived stem cells (hADSCs). We show that our G-A-PAA scaffold is capable of supporting hADSCs proliferation and survival, with no apparent cytotoxic effect. Moreover, we find that after exposure to prochondrogenic conditions a key transcription factor known to induce chondrogenesis, namely, Sox9, is highly expressed in our hADSCs/G-A-PAA bioconstruct, along with cartilage specific markers such as collagen type II, CEP68, and COMP extracellular matrix (ECM) components. These data suggest that our G-A-PAA structural properties and formulation might enable hADSCs conversion towards functional chondrocytes. We conclude that our novel G-A-PAA biomatrix is a good candidate for prospective in vivo CTE applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.