ReviewFrontiers in microbiology2015
Metabolic engineering of yeast to produce fatty acid-derived biofuels: bottlenecks and solutions.
Review in Frontiers in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Parameterization of cell-free systems with time-series data using KETCHUP.PLoS computational biology · 2025Article
- Integrating yeast biodiversity and machine learning for predictive metabolic engineering.FEMS yeast research · 2025Review
- Evaluating the effects of synthetic POM cycles and NAD+ kinase expression on fatty alcohol production in Saccharomyces cerevisiae.PloS one · 2025Article
- Advanced metabolic Engineering strategies for the sustainable production of free fatty acids and their derivatives using yeast.Journal of biological engineering · 2024Review
- Carbon efficient production of chemicals with yeasts.Yeast (Chichester, England) · 2023Review
- Human lipocalins bind and export fatty acids through the secretory pathway of yeast cells.Frontiers in microbiology · 2023Article
- Management of microbial enzymes for biofuels and biogas production by using metagenomic and genome editing approaches.3 Biotech · 2021Review
- Stable isotope and chemical inhibition analyses suggested the existence of a non-mevalonate-like pathway in the yeast Yarrowia lipolytica.Scientific reports · 2021Article
- Metabolomic Analysis of Response to Nitrogen-Limiting Conditions inMetabolites · 2020Article
- Bioengineering studies and pathway modeling of the heterologous biosynthesis of tetrahydrocannabinolic acid in yeast.Applied microbiology and biotechnology · 2020Review
- Engineering intracellular malonyl-CoA availability in microbial hosts and its impact on polyketide and fatty acid synthesis.Applied microbiology and biotechnology · 2020Review
- Robust and cost-saving static solid cultivation method for lipid production using the chlamydospores ofBiotechnology for biofuels · 2019Article
- Increasing medium chain fatty acids production in Yarrowia lipolytica by metabolic engineering.Microbial cell factories · 2018Article
- Production of γ-terpinene by metabolically engineeredRSC advances · 2018Article
- Gene repression via multiplex gRNA strategy in Y. lipolytica.Microbial cell factories · 2018Article
- Redirection of lipid flux toward phospholipids in yeast increases fatty acid turnover and secretion.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Genomic and phenotypic characterization of a refactored xylose-utilizingBiotechnology for biofuels · 2018Article
- Engineering tolerance to industrially relevant stress factors in yeast cell factories.FEMS yeast research · 2017Review
- Lipid production in Yarrowia lipolytica is maximized by engineering cytosolic redox metabolism.Nature biotechnology · 2017Article
- Microbial alkane production for jet fuel industry: motivation, state of the art and perspectives.Microbial biotechnology · 2017Review
Corrections and comments
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Authors and funding
2 authors.
Funding
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Abstract
Fatty acid-derived biofuels can be a better solution than bioethanol to replace petroleum fuel, since they have similar energy content and combustion properties as current transportation fuels. The environmentally friendly microbial fermentation process has been used to synthesize advanced biofuels from renewable feedstock. Due to their robustness as well as the high tolerance to fermentation inhibitors and phage contamination, yeast strains such as Saccharomyces cerevisiae and Yarrowia lipolytica have attracted tremendous attention in recent studies regarding the production of fatty acid-derived biofuels, including fatty acids, fatty acid ethyl esters, fatty alcohols, and fatty alkanes. However, the native yeast strains cannot produce fatty acids and fatty acid-derived biofuels in large quantities. To this end, we have summarized recent publications in this review on metabolic engineering of yeast strains to improve the production of fatty acid-derived biofuels, identified the bottlenecks that limit the productivity of biofuels, and categorized the appropriate approaches to overcome these obstacles.
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