ArticleFrontiers in microbiology2015
S-layers at second glance? Altiarchaeal grappling hooks (hami) resemble archaeal S-layer proteins in structure and sequence.
Article in Frontiers in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 42 citations in OpenAlex.
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- A multilayered cell envelope of a member of the Chloroflexota offers an anchoring platform for the archaellum.Frontiers in microbiology · 2026Article
- Tat-fimbriae ("tafi"): An unusual type of haloarchaeal surface structure depending on the twin-arginine translocation pathway.iScience · 2025Article
- Unusual cell surfaces, pili, and archaella of Thermoplasmatales archaea.The ISME journal · 2025Article
- Bio-inspired designs: leveraging biological brilliance in mechanical engineering-an overview.3 Biotech · 2024Review
- Towards a molecular picture of the archaeal cell surface.Nature communications · 2024Article
- Virus-Host Dynamics in Archaeal Groundwater Biofilms and the Associated Bacterial Community Composition.Viruses · 2023Article
- Comparative Genomics Provides Insights into the Genetic Diversity and Evolution of the DPANN Superphylum.mSystems · 2021Article
- Lytic archaeal viruses infect abundant primary producers in Earth's crust.Nature communications · 2021Article
- Taxonomic and functional analyses of intact microbial communities thriving in extreme, astrobiology-relevant, anoxic sites.Microbiome · 2021Article
- Plant-archaea relationships: a potential means to improve crop production in arid and semi-arid regions.World journal of microbiology & biotechnology · 2020Review
- Archaeal cell surface biogenesis.FEMS microbiology reviews · 2018Article
- Subgroup Characteristics of Marine Methane-Oxidizing ANME-2 Archaea and Their Syntrophic Partners as Revealed by Integrated Multimodal Analytical Microscopy.Applied and environmental microbiology · 2018Article
- Lactobacillus slpA promotes ESC growth through the ERK1/2 pathway.Cytotechnology · 2017Article
- Archaeal S-Layers: Overview and Current State of the Art.Frontiers in microbiology · 2017Review
- Culture Independent Genomic Comparisons Reveal Environmental Adaptations for Altiarchaeales.Frontiers in microbiology · 2016Article
- Diversity and Evolution of Type IV pili Systems in Archaea.Frontiers in microbiology · 2016Article
- "Altiarchaeales": uncultivated archaea from the subsurface.Life (Basel, Switzerland) · 2015Review
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Authors and funding
15 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The uncultivated "Candidatus Altiarchaeum hamiconexum" (formerly known as SM1 Euryarchaeon) carries highly specialized nano-grappling hooks ("hami") on its cell surface. Until now little is known about the major protein forming these structured fibrous cell surface appendages, the genes involved or membrane anchoring of these filaments. These aspects were analyzed in depth in this study using environmental transcriptomics combined with imaging methods. Since a laboratory culture of this archaeon is not yet available, natural biofilm samples with high Ca. A. hamiconexum abundance were used for the entire analyses. The filamentous surface appendages spanned both membranes of the cell, which are composed of glycosyl-archaeol. The hami consisted of multiple copies of the same protein, the corresponding gene of which was identified via metagenome-mapped transcriptome analysis. The hamus subunit proteins, which are likely to self-assemble due to their predicted beta sheet topology, revealed no similiarity to known microbial flagella-, archaella-, fimbriae- or pili-proteins, but a high similarity to known S-layer proteins of the archaeal domain at their N-terminal region (44-47% identity). Our results provide new insights into the structure of the unique hami and their major protein and indicate their divergent evolution with S-layer proteins.
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