ArticleFrontiers in human neuroscience2015
Changes in task-based effective connectivity in language networks following rehabilitation in post-stroke patients with aphasia.
Article in Frontiers in human neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01927302 (The Center for the Neurobiology of Language Recovery), which is not on this map. Cited by 50 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Center for the Neurobiology of Language Recovery (CNLR)
Who cites it
50 citing papers in PubMed.
- Hemispheric Network Dynamics During Auditory Language Comprehension and Its Clinical Implications Regarding Resting-State Functional Magnetic Resonance Imaging.Journal of speech, language, and hearing research : JSLHR · 2026Article
- Cortical hierarchy and aphasia severity: the sensorimotor-association gradient modulates lesion effects within language-specific networks.Communications biology · 2026Article
- Dynamic functional reorganization in post-stroke aphasia: a state-of-the-art fMRI review from disease evolution to intervention.Frontiers in neuroscience · 2026Review
- Naming practice effects and inconsistencies relate to treatment outcome in people with aphasia.Neuropsychologia · 2025Article
- Dynamic reorganization of task-related network interactions in post-stroke aphasia recovery.Brain : a journal of neurology · 2025Article
- Lesion-Induced Changes to the Network Controllability of the Right Pars Triangularis in Aphasia.Neurobiology of language (Cambridge, Mass.) · 2025Article
- Remapping and Reconnecting the Language Network after Stroke.Brain sciences · 2024Review
- Disentangling neuroplasticity mechanisms in post-stroke language recovery.Brain and language · 2024Review
- Efficacy of a gamified digital therapy for speech production in people with chronic aphasia (iTalkBetter): behavioural and imaging outcomes of a phase II item-randomised clinical trial.EClinicalMedicine · 2024Article
- Neural mechanisms of sentence production: a volumetric study of primary progressive aphasia.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Post-stroke aphasia rehabilitation using an adapted visual P300 brain-computer interface training: improvement over time, but specificity remains undetermined.Frontiers in human neuroscience · 2024Article
- Dynamic causal modeling of reorganization of memory and language networks in temporal lobe epilepsy.Annals of clinical and translational neurology · 2023Article
- Unraveling the Thread of Aphasia Rehabilitation: A Translational Cognitive Perspective.Biomedicines · 2023Review
- Treatment-induced neural reorganization in aphasia is language-domain specific: Evidence from a large-scale fMRI study.Cortex; a journal devoted to the study of the nervous system and behavior · 2023Article
- Review
- Predictors of Therapy Response in Chronic Aphasia: Building a Foundation for Personalized Aphasia Therapy.Journal of stroke · 2022Review
- Neural correlates of syntactic comprehension: A longitudinal study.Brain and language · 2022Article
- French Phonological Component Analysis and aphasia recovery: A bilingual perspective on behavioral and structural data.Frontiers in human neuroscience · 2022Article
- Grammar in 'agrammatical' aphasia: What's intact?PloS one · 2022Article
- Abnormally weak functional connections get stronger in chronic stroke patients who benefit from naming therapy.Brain and language · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
In this study, we examined regions in the left and right hemisphere language network that were altered in terms of the underlying neural activation and effective connectivity subsequent to language rehabilitation. Eight persons with chronic post-stroke aphasia and eight normal controls participated in the current study. Patients received a 10 week semantic feature-based rehabilitation program to improve their skills. Therapy was provided on atypical examples of one trained category while two control categories were monitored; the categories were counterbalanced across patients. In each fMRI session, two experimental tasks were conducted: (a) picture naming and (b) semantic feature verification of trained and untrained categories. Analysis of treatment effect sizes revealed that all patients showed greater improvements on the trained category relative to untrained categories. Results from this study show remarkable patterns of consistency despite the inherent variability in lesion size and activation patterns across patients. Across patients, activation that emerged as a function of rehabilitation on the trained category included bilateral IFG, bilateral SFG, LMFG, and LPCG for picture naming; and bilateral IFG, bilateral MFG, LSFG, and bilateral MTG for semantic feature verification. Analysis of effective connectivity using Dynamic Causal Modeling (DCM) indicated that LIFG was the consistently significantly modulated region after rehabilitation across participants. These results indicate that language networks in patients with aphasia resemble normal language control networks and that this similarity is accentuated by rehabilitation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.