ArticleFrontiers in molecular neuroscience2015
Wide-field Ca(2+) imaging reveals visually evoked activity in the retrosplenial area.
Article in Frontiers in molecular neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 56 citations in OpenAlex.
- Anterior and posterior retrosplenial cortex form distinct visuospatial circuits in the mouse.Nature communications · 2026Article
- Multimodal dataset linking wide-field calcium imaging to behavior changes in operant lever-pull task in mice.Scientific data · 2025Article
- Spatial reasoning via recurrent neural dynamics in mouse retrosplenial cortex.Nature neuroscience · 2025Article
- Highly selective visual receptive fields in mouse frontal cortex.bioRxiv : the preprint server for biology · 2025Article
- Gating of Social Behavior by Inhibitory Inputs from Hippocampal CA1 to Retrosplenial Agranular Cortex.Neuroscience bulletin · 2024Article
- NeuroActivityToolkit-Toolbox for Quantitative Analysis of Miniature Fluorescent Microscopy Data.Journal of imaging · 2023Article
- Age-associated reduction of nuclear shape dynamics in excitatory neurons of the visual cortex.Aging cell · 2023Article
- High sensitivity mapping of brain-wide functional networks in awake mice using simultaneous multi-slice fUS imaging.Imaging neuroscience (Cambridge, Mass.) · 2023Article
- Review
- Visuomotor learning promotes visually evoked activity in the medial prefrontal cortex.Cell reports · 2022Article
- Anatomical and functional connectomes underlying hierarchical visual processing in mouse visual system.Brain structure & function · 2022Review
- Context value updating and multidimensional neuronal encoding in the retrosplenial cortex.Nature communications · 2021Article
- Distinct prefrontal top-down circuits differentially modulate sensorimotor behavior.Nature communications · 2020Article
- Visual Sequences Drive Experience-Dependent Plasticity in Mouse Anterior Cingulate Cortex.Cell reports · 2020Article
- Stable Encoding of Visual Cues in the Mouse Retrosplenial Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Functional ultrasound imaging of deep visual cortex in awake nonhuman primates.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- The retrosplenial cortex and long-term spatial memory: from the cell to the network.Current opinion in behavioral sciences · 2020Review
- Neural mechanisms of sensorimotor transformation and action selection.The European journal of neuroscience · 2019Review
- Decoding cortical brain states from widefield calcium imaging data using visibility graph.Biomedical optics express · 2018Article
- The functional organization of cortical feedback inputs to primary visual cortex.Nature neuroscience · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Due to recent advances of genetic manipulation, mouse brain has become a useful model for studying brain function, which demands whole brain functional mapping techniques in the mouse brain. In the present study, to finely map visual responsive areas in the mouse brain, we combined high-resolution wide-field optical imaging with transgenic mice containing the genetically encoded Ca(2+) indicator, GCaMP3. With the high signal amplitude of GCaMP3 expressing in excitatory neurons, this system allowed neural activity to be observed with relatively fine spatial resolution and cell-type specificity. To evaluate this system, we examined whether non-visual areas exhibited a visual response over the entire surface of the mouse hemisphere. We found that two association areas, the retrosplenial area (RS) and secondary motor/anterior cingulate area (M2/AC), were significantly responsive to drifting gratings. Examination using gratings with distinct spatiotemporal frequency parameters revealed that the RS strongly responded to high-spatial and low-temporal frequency gratings. The M2/AC exhibited a response property similar to that of the RS, though it was not statistically significant. Finally, we performed cellular imaging using two-photon microscopy to examine orientation and direction selectivity of individual neurons, and found that a minority of neurons in the RS clearly showed visual responses sharply selective for orientation and direction. These results suggest that neurons in RS encode visual information of fine spatial details in images. Thus, the present study shows the usefulness of the functional mapping method using a combination of wide-field and two-photon Ca(2+) imaging, which allows for whole brain mapping with high spatiotemporal resolution and cell-type specificity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.