ArticleSubstance abuse : research and treatment2015
Novelty Seeking as a Phenotypic Marker of Adolescent Substance Use.
Article in Substance abuse : research and treatment, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 41 citations in OpenAlex.
- Social and Experiential Drivers of Adolescent Alcohol Use: Evidence from an Exploratory Concept Mapping Study.Children (Basel, Switzerland) · 2026Article
- Repeated Cocaine Intake Differentially Impacts Striatal DInternational journal of molecular sciences · 2023Article
- Multidimensional interdisciplinary variables influencing tourist online purchasing intention at World Heritage City (City of Yazd, Iran).SN business & economics · 2023Article
- Validation of the Substance Use Risk Profile Scale in Lithuanian population.Health and quality of life outcomes · 2020Article
- Anhedonia as a phenotypic marker of familial transmission of polysubstance use trajectories across midadolescence.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2019Article
- Associations Between the Dopamine D4 Receptor and DAT1 Dopamine Transporter Genes Polymorphisms and Personality Traits in Addicted Patients.International journal of environmental research and public health · 2018Article
- Associations between personality disorders and cannabis use and cannabis use disorder: a population-based twin study.Addiction (Abingdon, England) · 2018Article
- Novelty seeking mediates the effect of DRD3 variation on onset age of amphetamine dependence in Han Chinese population.European archives of psychiatry and clinical neuroscience · 2018Article
- Testing Genetic and Environmental Associations Between Personality Disorders and Cocaine Use: A Population-Based Twin Study.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2018Article
- Associations between anhedonia and marijuana use escalation across mid-adolescence.Addiction (Abingdon, England) · 2017Observational
- Polygenic Risk, Personality Dimensions, and Adolescent Alcohol Use Problems: A Longitudinal Study.Journal of studies on alcohol and drugs · 2017Article
- Cognitive Mechanisms and Therapeutic Targets of Addiction.Current opinion in behavioral sciences · 2017Article
- Novel Psychoactive Substances-Recent Progress on Neuropharmacological Mechanisms of Action for Selected Drugs.Frontiers in psychiatry · 2017Review
- Predicting substance use in emerging adulthood: A genetically informed study of developmental transactions between impulsivity and family conflict.Development and psychopathology · 2016Article
- Indirect Associations of Anxiety Sensitivity with Tobacco, Alcohol, and Other Drug Use Problems Through Emotional Disorder Symptoms in Adolescents.Behavioral medicine (Washington, D.C.)Article
- Synthetic Marijuana: Assessment of Usage, Motivation and Associated Risks in Adolescent Substance Users.Substance use : research and treatmentArticle
Corrections and comments
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Authors and funding
10 authors at 7 institutions in 1 country.
Funding
Abstract
Trait novelty seeking has been consistently implicated in substance use, yet the origins and mechanisms of novelty seeking in substance use proneness are unclear. We aimed to characterize novelty seeking as a phenotypic marker of substance use proneness in adolescence, a critical period for drug use experimentation. To this end, we parsed novelty seeking's two constituent subdimensions - exploratory excitability (drive for novel experience) and impulsiveness (careless decision-making) - and explored the individual relations of these dimensions to: (1) the use of a variety of licit and illicit substances, (2) family history of substance use, and (3) subjective drug effects. Five hundred eighty five adolescents (mean age = 14.5 years) completed surveys of key variables. Results indicated that, when accounting for the covariation among exploratory excitability and impulsiveness, impulsiveness emerged as the more salient correlate of substance use and was independently associated with initiation of nearly all drug classes. Mediation analyses of the mechanisms of novelty seeking-related risk illustrated that impulsiveness mediated the association of family history of substance use with both initiation and past 30-day frequency of use. Both impulsiveness and exploratory excitability were associated with increased positive and negative subjective drug effects, and the analyses supported a significant indirect pathway from impulsiveness to a more frequent use via positive subjective effects. Although limited by a cross-sectional design, these findings suggest that impulsiveness-like aspects of the novelty seeking construct may represent a useful phenotypic marker for early substance use proneness that potentially (1) increases initiation risk, (2) has familial origins, and (3) promotes more frequent use by altering subjective drug response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.