Evidence map›Paper›PMID 26106218›Full record

ArticleStem cells translational medicine2015

Postinfarction Functional Recovery Driven by a Three-Dimensional Engineered Fibrin Patch Composed of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells.

Santiago Roura, Carolina Soler-Botija, Juli R Bagó, Aida Llucià-Valldeperas, Marco A Férnandez, Carolina Gálvez-Montón, Cristina Prat-Vidal, Isaac Perea-Gil, Jerónimo Blanco, Antoni Bayes-Genis

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells translational medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 46 citations in OpenAlex.

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  13. Recent Development in Therapeutic Cardiac Patches.Frontiers in cardiovascular medicine · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Santiago RouraHeart Failure and Cardiac Regeneration Research Program and Flow Cytometry Facility, Germans Trias i Pujol Health Science Research Institute, Badalona, Spain; Cell Therapy Group, Institute for Advanced Chemistry of Catalonia, Barcelona, Spain; Biomedical Research Networking Center on Bioengineering, Biomaterials and Nanomedicine, Zaragoza, Spain; Cardiology Service, University Hospital, Germans Trias i Pujol, Badalona, Spain; Department of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.
Carolina Soler-BotijaHeart Failure and Cardiac Regeneration Research Program and Flow Cytometry Facility, Germans Trias i Pujol Health Science Research Institute, Badalona, Spain; Cell Therapy Group, Institute for Advanced Chemistry of Catalonia, Barcelona, Spain; Biomedical Research Networking Center on Bioengineering, Biomaterials and Nanomedicine, Zaragoza, Spain; Cardiology Service, University Hospital, Germans Trias i Pujol, Badalona, Spain; Department of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.
Juli R BagóHeart Failure and Cardiac Regeneration Research Program and Flow Cytometry Facility, Germans Trias i Pujol Health Science Research Institute, Badalona, Spain; Cell Therapy Group, Institute for Advanced Chemistry of Catalonia, Barcelona, Spain; Biomedical Research Networking Center on Bioengineering, Biomaterials and Nanomedicine, Zaragoza, Spain; Cardiology Service, University Hospital, Germans Trias i Pujol, Badalona, Spain; Department of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.
Aida Llucià-ValldeperasHeart Failure and Cardiac Regeneration Research Program and Flow Cytometry Facility, Germans Trias i Pujol Health Science Research Institute, Badalona, Spain; Cell Therapy Group, Institute for Advanced Chemistry of Catalonia, Barcelona, Spain; Biomedical Research Networking Center on Bioengineering, Biomaterials and Nanomedicine, Zaragoza, Spain; Cardiology Service, University Hospital, Germans Trias i Pujol, Badalona, Spain; Department of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.
Marco A FérnandezHeart Failure and Cardiac Regeneration Research Program and Flow Cytometry Facility, Germans Trias i Pujol Health Science Research Institute, Badalona, Spain; Cell Therapy Group, Institute for Advanced Chemistry of Catalonia, Barcelona, Spain; Biomedical Research Networking Center on Bioengineering, Biomaterials and Nanomedicine, Zaragoza, Spain; Cardiology Service, University Hospital, Germans Trias i Pujol, Badalona, Spain; Department of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.
Carolina Gálvez-MontónHeart Failure and Cardiac Regeneration Research Program and Flow Cytometry Facility, Germans Trias i Pujol Health Science Research Institute, Badalona, Spain; Cell Therapy Group, Institute for Advanced Chemistry of Catalonia, Barcelona, Spain; Biomedical Research Networking Center on Bioengineering, Biomaterials and Nanomedicine, Zaragoza, Spain; Cardiology Service, University Hospital, Germans Trias i Pujol, Badalona, Spain; Department of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.
Cristina Prat-VidalHeart Failure and Cardiac Regeneration Research Program and Flow Cytometry Facility, Germans Trias i Pujol Health Science Research Institute, Badalona, Spain; Cell Therapy Group, Institute for Advanced Chemistry of Catalonia, Barcelona, Spain; Biomedical Research Networking Center on Bioengineering, Biomaterials and Nanomedicine, Zaragoza, Spain; Cardiology Service, University Hospital, Germans Trias i Pujol, Badalona, Spain; Department of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.
Isaac Perea-GilHeart Failure and Cardiac Regeneration Research Program and Flow Cytometry Facility, Germans Trias i Pujol Health Science Research Institute, Badalona, Spain; Cell Therapy Group, Institute for Advanced Chemistry of Catalonia, Barcelona, Spain; Biomedical Research Networking Center on Bioengineering, Biomaterials and Nanomedicine, Zaragoza, Spain; Cardiology Service, University Hospital, Germans Trias i Pujol, Badalona, Spain; Department of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.
Jerónimo BlancoHeart Failure and Cardiac Regeneration Research Program and Flow Cytometry Facility, Germans Trias i Pujol Health Science Research Institute, Badalona, Spain; Cell Therapy Group, Institute for Advanced Chemistry of Catalonia, Barcelona, Spain; Biomedical Research Networking Center on Bioengineering, Biomaterials and Nanomedicine, Zaragoza, Spain; Cardiology Service, University Hospital, Germans Trias i Pujol, Badalona, Spain; Department of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.
Antoni Bayes-GenisHeart Failure and Cardiac Regeneration Research Program and Flow Cytometry Facility, Germans Trias i Pujol Health Science Research Institute, Badalona, Spain; Cell Therapy Group, Institute for Advanced Chemistry of Catalonia, Barcelona, Spain; Biomedical Research Networking Center on Bioengineering, Biomaterials and Nanomedicine, Zaragoza, Spain; Cardiology Service, University Hospital, Germans Trias i Pujol, Badalona, Spain; Department of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain abayes.germanstrias@gencat.cat.
Badalona Serveis Assistencials · ESBiomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine · ESInstitut d'Investigació en Ciències de la Salut Germans Trias i Pujol · ESInstitute of Advanced Chemistry of Catalonia · ESUniversitat Autònoma de Barcelona · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Considerable research has been dedicated to restoring myocardial cell slippage and limiting ventricular remodeling after myocardial infarction (MI). We examined the ability of a three-dimensional (3D) engineered fibrin patch filled with human umbilical cord blood-derived mesenchymal stem cells (UCBMSCs) to induce recovery of cardiac function after MI. The UCBMSCs were modified to coexpress luciferase and fluorescent protein reporters, mixed with fibrin, and applied as an adhesive, viable construct (fibrin-cell patch) over the infarcted myocardium in mice (MI-UCBMSC group). The patch adhered well to the heart. Noninvasive bioluminescence imaging demonstrated early proliferation and differentiation of UCBMSCs within the construct in the postinfarct mice in the MI-UCBMSC group. The implanted cells also participated in the formation of new, functional microvasculature that connected the fibrin-cell patch to both the subjacent myocardial tissue and the host circulatory system. As revealed by echocardiography, the left ventricular ejection fraction and fractional shortening at sacrifice were improved in MI-UCBMSC mice and were markedly reduced in mice treated with fibrin alone and untreated postinfarction controls. In conclusion, a 3D engineered fibrin patch composed of UCBMSCs attenuated infarct-derived cardiac dysfunction when transplanted locally over a myocardial wound.

Indexed as

Mesenchymal Stem CellsMesenchymal Stem Cell TransplantationAnimalsCell DifferentiationFetal BloodFibrinHumansMiceMyocardial InfarctionFibrinCardiac functionFibrinMesenchymal stem cellsMyocardial infarctionPatchUmbilical cord blood

Identifiers

PMID26106218
PMCPMC4511144
OpenAlexW2239695784

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.