Evidence map›Paper›PMID 26106167›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2015

Metaanalysis of flawed expression profiling data leading to erroneous Parkinson's biomarker identification.

Lilah Toker, Paul Pavlidis

Abstract readLetterComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Reply to Toker and Pavlidis: Blood biomarkers for Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America · 2015
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Lilah TokerDepartment of Psychiatry and Centre for High-Throughput Biology, Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada V6T1Z4.
Paul PavlidisDepartment of Psychiatry and Centre for High-Throughput Biology, Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada V6T1Z4 paul@chibi.ubc.ca.

Funding

Neuroinformatics for gene expression: networks, function and meta-analysisR01MH111099 · NIMH · UNIVERSITY OF BRITISH COLUMBIA · PI PAVLIDIS, PAUL · 2016 to 2025
$3.6M
NIMH NIH HHS R01 MH111099
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

BiomarkersHepatocyte Nuclear Factor 4Heterogeneous-Nuclear RibonucleoproteinsHumansParkinson DiseasePolypyrimidine Tract-Binding ProteinBiomarkersHepatocyte Nuclear Factor 4Heterogeneous-Nuclear RibonucleoproteinsPolypyrimidine Tract-Binding Protein

Identifiers

PMID26106167
PMCPMC4507209

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.