Trial reportProceedings of the National Academy of Sciences of the United States of America2015
Ongoing dynamics in large-scale functional connectivity predict perception.
Trial report in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 145 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
145 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Application of Graph Theory for Identifying Connectivity Patterns in Human Brain Networks: A Systematic Review.Frontiers in neuroscience · 2019Pooled it
- Modular reconfiguration of an auditory control brain network supports adaptive listening behavior.Proceedings of the National Academy of Sciences of the United States of America · 2019Trial
- Modular Brain Network Organization Predicts Response to Cognitive Training in Older Adults.PloS one · 2016Trial
- Human cortex organizes dynamic co-fluctuations along the sensorimotor-association axis.Nature communications · 2026Article
- The prefrontal cortex across scales: laminar architecture, white-matter constraints, and distributed control in cognition.Brain structure & function · 2026Review
- Shared spatial and temporal principles govern connectome dynamics across timescales.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The dual interpretation of edge time series: Time-varying connectivity versus statistical interaction.iScience · 2026Article
- Forecasting Perception Before It Happens: Context-Specific Connectivity Patterns Predict Perceptual Outcomes.bioRxiv : the preprint server for biology · 2026Article
- Flexible brain state engagement predicts cognitive control transdiagnostically.bioRxiv : the preprint server for biology · 2026Article
- Global neural oscillations underlie performance variability and attentional state fluctuations in humans.Scientific reports · 2026Article
- Intrinsic network static and dynamic functional connectivity associated with induced affect.Social cognitive and affective neuroscience · 2026Article
- Article
- Brain-wide resting-state fMRI network dynamics elicited by activation of single thalamic input.Nature communications · 2025Article
- Using an ordinary differential equation model to separate rest and task signals in fMRI.Nature communications · 2025Article
- Neuromodulatory influences on propagation of traveling waves along the unimodal-transmodal gradient.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- A multiplex of connectome trajectories enables several connectivity patterns in parallel.eLife · 2025Article
- Modulatory Neurotransmitter Genotypes Shape Dynamic Functional Connectome Reconfigurations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Dynamic Network Plasticity and Sample Efficiency in Biological Neural Cultures: A Comparative Study with Deep Reinforcement Learning.Cyborg and bionic systems (Washington, D.C.) · 2025Article
- Identifying dynamic reproducible brain states using a predictive modelling approach.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Functional anatomy and topographical organization of the frontotemporal arcuate fasciculus.Communications biology · 2024Article
85 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Most brain activity occurs in an ongoing manner not directly locked to external events or stimuli. Regional ongoing activity fluctuates in unison with some brain regions but not others, and the degree of long-range coupling is called functional connectivity, often measured with correlation. Strength and spatial distributions of functional connectivity dynamically change in an ongoing manner over seconds to minutes, even when the external environment is held constant. Direct evidence for any behavioral relevance of these continuous large-scale dynamics has been limited. Here, we investigated whether ongoing changes in baseline functional connectivity correlate with perception. In a continuous auditory detection task, participants perceived the target sound in roughly one-half of the trials. Very long (22-40 s) interstimulus intervals permitted investigation of baseline connectivity unaffected by preceding evoked responses. Using multivariate classification, we observed that functional connectivity before the target predicted whether it was heard or missed. Using graph theoretical measures, we characterized the difference in functional connectivity between states that lead to hits vs. misses. Before misses compared with hits and task-free rest, connectivity showed reduced modularity, a measure of integrity of modular network structure. This effect was strongest in the default mode and visual networks and caused by both reduced within-network connectivity and enhanced across-network connections before misses. The relation of behavior to prestimulus connectivity was dissociable from that of prestimulus activity amplitudes. In conclusion, moment to moment dynamic changes in baseline functional connectivity may shape subsequent behavioral performance. A highly modular network structure seems beneficial to perceptual efficiency.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.