ReviewCarcinogenesis2015
Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death.
Open access · bronzeAbstract readReview
In one paragraph
Review in Carcinogenesis, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.4field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 43 citations in OpenAlex.
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- Autoimmune Responses and Therapeutic Interventions for Systemic Lupus Erythematosus: A Comprehensive Review.Endocrine, metabolic & immune disorders drug targets · 2024Review
- Cell cycle exits and U-turns: Quiescence as multiple reversible forms of arrest.Faculty reviews · 2023Review
- Emerging Roles and Mechanisms of lncRNA FOXD3-AS1 in Human Diseases.Frontiers in oncology · 2022Review
- Bbc3 Loss Enhances Survival and Protein Clearance in Neurons Exposed to the Organophosphate Pesticide Chlorpyrifos.Toxicological sciences : an official journal of the Society of Toxicology · 2021Article
- Curation of cancer hallmark-based genes and pathways for in silico characterization of chemical carcinogenesis.Database : the journal of biological databases and curation · 2020Article
- The Analysis of Bifenox and Dichlobenil Toxicity in Selected Microorganisms and Human Cancer Cells.International journal of environmental research and public health · 2019Article
- Cytotoxic and genotoxic effect of oxyfluorfen on hemocytes of Biomphalaria glabrata.Environmental science and pollution research international · 2019Article
- Recombinant helical plant virus-based nanoparticles for vaccination and immunotherapy.Virus genes · 2018Review
- Toxicity implications for early life stage Japanese medaka (Oryzias latipes) exposed to oxyfluorfen.Environmental toxicology · 2018Article
- Aberrant control of NF-κB in cancer permits transcriptional and phenotypic plasticity, to curtail dependence on host tissue: molecular mode.Cancer biology & medicine · 2017Article
- Anticancer Natural Compounds as Epigenetic Modulators of Gene Expression.Current genomics · 2017Review
- Natural Compounds As Modulators of Non-apoptotic Cell Death in Cancer Cells.Current genomics · 2017Article
- Low-Dose Mixture Hypothesis of Carcinogenesis Workshop: Scientific Underpinnings and Research Recommendations.Environmental health perspectives · 2017Article
- A Perspective Discussion on Rising Pesticide Levels and Colon Cancer Burden in Brazil.Frontiers in public health · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
39 authors at 18 institutions in 11 countries.
Kannan Badri NarayananDepartment of Chemistry and Biochemistry, Yeungnam University, Gyeongsan 712-749, South Korea, Sultan Zainal Abidin University, Malaysia, Plant Biotechnologies Inc, St. Albert AB, Canada, Computer Science Department, Southern Illinois University, Carbondale, IL 62901, USA, Department of Urology, University of California Davis, Sacramento, CA 95817, USA, Department of Pharmacology and Toxicology, University of Vienna, Austria, University of Puerto Rico, Medical Sciences Campus, School of Public Health, Nutrition Program, San Juan Puerto Rico 00936-5067, USA, Department of Anatomy, College of Medicine, Yeungnam University, Daegu, 705-717, South Korea, School of Biomedical Science, The Chinese University Of Hong Kong, Hong Kong, China, Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand, Department of Otolaryngology/Head and Neck Surgery, Head and Neck Cancer Research Division, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA, Department of Pharmaceutical Sciences, Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506, USA, Department of Molecular Medicine and Medical Biotechnology, Federico II University of Naples, 80131 Naples, Italy, Department of Molecular and Experimental Medicine, MEM 180, The Scripps Research Institute, La Jolla, CA 92037, USA, Department of Biology, Jackson State University, Jackson, MS 39217, USA, Department of Pathology, Kuwait University, Safat 13110, Kuwait, Department of Experimental and Clinical Medicine, University of Firenze, Firenze, 50134, Italy, Department of Environmental and Radiological Health Sciences, Colorado state University/ Colorado School of Public Health, Fort Collins, CO 80523-1680, USA, Center for Environmental Carcinogenesis and Risk Assessment, Environmental Protection and Health Prevention Agency, Bologna, 40126, Italy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Se
Manaf AliSultan Zainal Abidin University, Malaysia.
Barry J BarclayPlant Biotechnologies Inc, St. Albert AB, Canada.
Qiang Shawn ChengComputer Science Department, Southern Illinois University, Carbondale, IL 62901, USA.
Leandro D'AbronzoDepartment of Urology, University of California Davis, Sacramento, CA 95817, USA.
Rita Dornetshuber-FleissDepartment of Pharmacology and Toxicology, University of Vienna, Austria.
Paramita M GhoshDepartment of Urology, University of California Davis, Sacramento, CA 95817, USA.
Michael J Gonzalez GuzmanUniversity of Puerto Rico, Medical Sciences Campus, School of Public Health, Nutrition Program, San Juan Puerto Rico 00936-5067, USA.
Tae-Jin LeeDepartment of Anatomy, College of Medicine, Yeungnam University, Daegu, 705-717, South Korea.
Po Sing LeungSchool of Biomedical Science, The Chinese University Of Hong Kong, Hong Kong, China.
Lin LiSchool of Biomedical Science, The Chinese University Of Hong Kong, Hong Kong, China.
Suidjit LuanpitpongSiriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
Edward RatovitskiDepartment of Otolaryngology/Head and Neck Surgery, Head and Neck Cancer Research Division, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Yon RojanasakulDepartment of Pharmaceutical Sciences, Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506, USA.
Maria Fiammetta RomanoDepartment of Molecular Medicine and Medical Biotechnology, Federico II University of Naples, 80131 Naples, Italy.
Simona RomanoDepartment of Molecular Medicine and Medical Biotechnology, Federico II University of Naples, 80131 Naples, Italy.
Ranjeet K SinhaDepartment of Molecular and Experimental Medicine, MEM 180, The Scripps Research Institute, La Jolla, CA 92037, USA.
Clement YedjouDepartment of Biology, Jackson State University, Jackson, MS 39217, USA.
Fahd Al-MullaDepartment of Pathology, Kuwait University, Safat 13110, Kuwait.
Rabeah Al-TemaimiDepartment of Pathology, Kuwait University, Safat 13110, Kuwait.
Amedeo AmedeiDepartment of Experimental and Clinical Medicine, University of Firenze, Firenze, 50134, Italy.
Dustin G BrownDepartment of Environmental and Radiological Health Sciences, Colorado state University/ Colorado School of Public Health, Fort Collins, CO 80523-1680, USA.
Elizabeth P RyanDepartment of Environmental and Radiological Health Sciences, Colorado state University/ Colorado School of Public Health, Fort Collins, CO 80523-1680, USA.
Annamaria ColacciCenter for Environmental Carcinogenesis and Risk Assessment, Environmental Protection and Health Prevention Agency, Bologna, 40126, Italy.
Roslida A HamidFaculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor 43400, Malaysia.
Chiara MondelloInstitute of Molecular Genetics, National Research Council, Pavia, 27100, Italy.
Jayadev RajuToxicology Research Division, Bureau of Chemical Safety Food Directorate, Health Products and Food Branch Health Canada, Ottawa, Ontario, K1A0K9, Canada.
Hosni K SalemUrology Department, Kasr Al-Ainy School of Medicine, Cairo University, El Manial, Cairo, 12515, Egypt.
Jordan WoodrickMolecular Oncology Program, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington DC, 20057, USA.
A Ivana ScovassiInstitute of Molecular Genetics, National Research Council, Pavia, 27100, Italy.
Neetu SinghAdvenced Molecular Science Research Centre, King George's Medical University, Lucknow, Uttar Pradesh, 226003, India.
Monica VaccariCenter for Environmental Carcinogenesis and Risk Assessment, Environmental Protection and Health Prevention Agency, Bologna, 40126, Italy.
Rabindra RoyMolecular Oncology Program, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington DC, 20057, USA.
Stefano ForteMediterranean Institute of Oncology, Viagrande, 95029, Italy.
Lorenzo MemeoMediterranean Institute of Oncology, Viagrande, 95029, Italy.
Seo Yun KimDepartment of Internal Medicine, Korea Cancer Center Hospital, Seoul 139-706, South Korea.
William H BissonEnvironmental and Molecular Toxicology, Environmental Health Science Center, Oregon State University, Corvallis, OR 97331, USA and.
Leroy LoweGetting to Know Cancer, Truro, Nova Scotia, Canada.
Hyun Ho ParkDepartment of Chemistry and Biochemistry, Yeungnam University, Gyeongsan 712-749, South Korea, Sultan Zainal Abidin University, Malaysia, Plant Biotechnologies Inc, St. Albert AB, Canada, Computer Science Department, Southern Illinois University, Carbondale, IL 62901, USA, Department of Urology, University of California Davis, Sacramento, CA 95817, USA, Department of Pharmacology and Toxicology, University of Vienna, Austria, University of Puerto Rico, Medical Sciences Campus, School of Public Health, Nutrition Program, San Juan Puerto Rico 00936-5067, USA, Department of Anatomy, College of Medicine, Yeungnam University, Daegu, 705-717, South Korea, School of Biomedical Science, The Chinese University Of Hong Kong, Hong Kong, China, Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand, Department of Otolaryngology/Head and Neck Surgery, Head and Neck Cancer Research Division, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA, Department of Pharmaceutical Sciences, Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506, USA, Department of Molecular Medicine and Medical Biotechnology, Federico II University of Naples, 80131 Naples, Italy, Department of Molecular and Experimental Medicine, MEM 180, The Scripps Research Institute, La Jolla, CA 92037, USA, Department of Biology, Jackson State University, Jackson, MS 39217, USA, Department of Pathology, Kuwait University, Safat 13110, Kuwait, Department of Experimental and Clinical Medicine, University of Firenze, Firenze, 50134, Italy, Department of Environmental and Radiological Health Sciences, Colorado state University/ Colorado School of Public Health, Fort Collins, CO 80523-1680, USA, Center for Environmental Carcinogenesis and Risk Assessment, Environmental Protection and Health Prevention Agency, Bologna, 40126, Italy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Se
Chinese University of Hong Kong · CNKuwait University · KWUniversity of California, Davis · USUniversity of Naples Federico II · ITYeungnam University · KRCairo University · EGGeorgetown University · USGeorgetown University Medical Center · USJackson State University · USJohns Hopkins University · USKing George's Medical University · INMahidol University · THOregon State University · USSouthern Illinois University Carbondale · USSultan Zainal Abidin University · MYUniversiti Putra Malaysia · MYUniversity of Florence · ITUniversity of Vienna · AT
Funding
Training and Mentoring Core P20GM103476 · NIGMS · UNIVERSITY OF SOUTHERN MISSISSIPPI · PI Vijay Rangachari · 2012 to 2026
$60.2MRCMI-Center for Environmental HealthG12MD007581 · NIMHD · JACKSON STATE UNIVERSITY · PI TCHOUNWOU, PAUL B. · 2012 to 2017
$11.2MTRAINING GRANT IN TUMOR BIOLOGYT32CA009686 · NCI · GEORGETOWN UNIVERSITY · PI ANNA Tate RIEGEL, DAVID J ROBBINS · 1996 to 2026
$10.8MRegulations of DNA Alkylation/Deamination Damage RepairR01CA092306 · NCI · INSTITUTE FOR CANCER PREVENTION · PI ROY, RABINDRA · 2003 to 2013
$2.8MInduction of Neoplastic Transformation and Cancer Stem Cells by Carbon NanotubesR01ES022968 · NIEHS · WEST VIRGINIA UNIVERSITY · PI ROJANASAKUL, YON · 2014 to 2019
$1.7MDNA Repair of Endogenous Lesions in CarcinogenesisR01CA113447 · NCI · GEORGETOWN UNIVERSITY · PI ROY, RABINDRA · 2006 to 2010
$1.4MThe Halifax Project: Chemical Mixtures and CancerR13ES023276 · NIEHS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI CARPENTER, DAVID ORLO · 2013 to 2013
$25kNCI NIH HHS R01 CA092306NCI NIH HHS R01 CA113447NCI NIH HHS T32 CA009686NIEHS NIH HHS R01-ES022968NIEHS NIH HHS R13 ES023276NIGMS NIH HHS P20 GM103476NIGMS NIH HHS P20GM103476NIMHD NIH HHS G12 MD007581NIMHD NIH HHS G12MD007581
Abstract
Cell death is a process of dying within biological cells that are ceasing to function. This process is essential in regulating organism development, tissue homeostasis, and to eliminate cells in the body that are irreparably damaged. In general, dysfunction in normal cellular death is tightly linked to cancer progression. Specifically, the up-regulation of pro-survival factors, including oncogenic factors and antiapoptotic signaling pathways, and the down-regulation of pro-apoptotic factors, including tumor suppressive factors, confers resistance to cell death in tumor cells, which supports the emergence of a fully immortalized cellular phenotype. This review considers the potential relevance of ubiquitous environmental chemical exposures that have been shown to disrupt key pathways and mechanisms associated with this sort of dysfunction. Specifically, bisphenol A, chlorothalonil, dibutyl phthalate, dichlorvos, lindane, linuron, methoxychlor and oxyfluorfen are discussed as prototypical chemical disruptors; as their effects relate to resistance to cell death, as constituents within environmental mixtures and as potential contributors to environmental carcinogenesis.
Indexed as
AnimalsCarcinogenesisCarcinogens, EnvironmentalCell DeathEnvironmental ExposureHazardous SubstancesHomeostasisHumansNeoplasmsCarcinogens, EnvironmentalHazardous Substances
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