ReviewCarcinogenesis2015
Causes of genome instability: the effect of low dose chemical exposures in modern society.
Open access · bronzeAbstract readReview
In one paragraph
Review in Carcinogenesis, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed, 3 pooled it
6.4field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
97 citing papers in PubMed, 3 syntheses or guidelines pooled it, 221 citations in OpenAlex.
- Differences in the risk association of TERT rs2736098 (C > T) with lung cancer between Caucasian and Asian populations: A meta-analysis.Scientific reports · 2025Pooled it
- Ethnicity-specific association between TERT rs2736100 (A > C) polymorphism and lung cancer risk: a comprehensive meta-analysis.Scientific reports · 2023Pooled it
- Meta-analysis of chromosomal aberrations as a biomarker of exposure in healthcare workers occupationally exposed to antineoplastic drugs.Mutation research. Reviews in mutation researchPooled it
- Navigating luminal heterogeneity: etiology-based proteogenomic subtyping for targeted treatment strategies in breast cancer.Molecular cancer · 2026Article
- Understanding Cancer Health Disparities.Cancers · 2026Review
- Telomerase mRNA therapy protects human skin against radiation-induced DNA damage.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- Investigating the Consequences of Aneuploidy in Cancer and Normal Tissue.Advances in experimental medicine and biology · 2026Review
- Calcium hydroxide nanoparticles induce apoptotic cell death in human pancreatic cancer cells through over ROS-driven genomic instability and mitochondrial dysfunction.Scientific reports · 2025Article
- Protecting Firefighters from Carcinogenic Exposure: Emerging Tools for PAH Detection and Decontamination.Biosensors · 2025Review
- Delayed complications of sulfur mustard poisoning: a focus on inflammation and telomere footprint.Archives of toxicology · 2025Review
- Uridine, a Therapeutic Nucleoside, Exacerbates Alcoholic Liver Disease via SRC Kinase Activation: A Network Toxicology and Molecular Dynamics Perspective.International journal of molecular sciences · 2025Article
- TheLife (Basel, Switzerland) · 2025Article
- Revisiting the approaches to DNA damage detection in genetic toxicology: insights and regulatory implications.BioData mining · 2025Article
- hTERT and SV40LgT Renal Cell Lines Adjust Their Transcriptional Responses After Copy Number Changes from the Parent Proximal Tubule Cells.International journal of molecular sciences · 2025Article
- The radiogenomic and spatiogenomic landscapes of glioblastoma and their relationship to oncogenic drivers.Communications medicine · 2025Article
- The cancer microbiome.Advances in clinical chemistry · 2025Review
- Cytokinesis-Blocking Micronucleus Assay for Assessing Nuclear Chromatin Integrity Abnormalities in Dog's Somatic Cells After Exposure to HVAD-Produced Silver Nanoparticles.International journal of molecular sciences · 2024Article
- Centromeres in cancer: Unraveling the link between chromosomal instability and tumorigenesis.Medical oncology (Northwood, London, England) · 2024Review
- Chromosomal instability: a key driver in glioma pathogenesis and progression.European journal of medical research · 2024Review
- Review
37 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
41 authors at 18 institutions in 11 countries.
Sabine A S LangieEnvironmental Risk and Health Unit, Flemish Institute for Technological Research (VITO), Boeretang 200, 2400 Mol, Belgium, Health Canada, Environmental Health Sciences and Research Bureau, Environmental Health Centre, Ottawa, Ontario K1A0K9, Canada, Department of Pathology, Kuwait University, Safat 13110, Kuwait, Department of Experimental and Clinical Medicine, University of Firenze, Florence 50134, Italy, Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Navarra, Pamplona 31009, Spain, Environmental and Molecular Toxicology, Environmental Health Sciences Center, Oregon State University, Corvallis, OR 97331, USA, Department of Environmental and Radiological Health Sciences/Food Science and Human Nutrition, College of Veterinary Medicine and Biomedical Sciences, Colorado State University/Colorado School of Public Health, Fort Collins, CO 80523-1680, USA, Department of Chemicals and Radiation, Division of Environmental Medicine, Norwegian Institute of Public Health, PO Box 4404, N-0403 Oslo, Norway, Hopkins Building, School of Biological Sciences, University of Reading, Reading, Berkshire RG6 6UB, UK, Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA, Center for Environmental Carcinogenesis and Risk Assessment, Environmental Protection and Health Prevention Agency, Bologna 40126, Italy, Human and Environmental Safety Research, Department of Health Sciences, College of North Atlantic, Doha, State of Qatar, Mediterranean Institute of Oncology, 95029 Viagrande, Italy, Laboratory for Cell Genetics, Vrije Universiteit Brussel, Brussels 1050, Belgium, Department of Biomedical Science, Faculty of Medicine and Health Sciences, University Putra, Serdang 43400, Selangor, Malaysia, University of Copenhagen, Department of Public Health, Copenhagen 1353, Denmark, Institute of Molecular Genetics, National Research Council, Pavia 27100, Italy, Medical Phys
Gudrun KoppenEnvironmental Risk and Health Unit, Flemish Institute for Technological Research (VITO), Boeretang 200, 2400 Mol, Belgium, Health Canada, Environmental Health Sciences and Research Bureau, Environmental Health Centre, Ottawa, Ontario K1A0K9, Canada, Department of Pathology, Kuwait University, Safat 13110, Kuwait, Department of Experimental and Clinical Medicine, University of Firenze, Florence 50134, Italy, Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Navarra, Pamplona 31009, Spain, Environmental and Molecular Toxicology, Environmental Health Sciences Center, Oregon State University, Corvallis, OR 97331, USA, Department of Environmental and Radiological Health Sciences/Food Science and Human Nutrition, College of Veterinary Medicine and Biomedical Sciences, Colorado State University/Colorado School of Public Health, Fort Collins, CO 80523-1680, USA, Department of Chemicals and Radiation, Division of Environmental Medicine, Norwegian Institute of Public Health, PO Box 4404, N-0403 Oslo, Norway, Hopkins Building, School of Biological Sciences, University of Reading, Reading, Berkshire RG6 6UB, UK, Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA, Center for Environmental Carcinogenesis and Risk Assessment, Environmental Protection and Health Prevention Agency, Bologna 40126, Italy, Human and Environmental Safety Research, Department of Health Sciences, College of North Atlantic, Doha, State of Qatar, Mediterranean Institute of Oncology, 95029 Viagrande, Italy, Laboratory for Cell Genetics, Vrije Universiteit Brussel, Brussels 1050, Belgium, Department of Biomedical Science, Faculty of Medicine and Health Sciences, University Putra, Serdang 43400, Selangor, Malaysia, University of Copenhagen, Department of Public Health, Copenhagen 1353, Denmark, Institute of Molecular Genetics, National Research Council, Pavia 27100, Italy, Medical Phys
Daniel DesaulniersHealth Canada, Environmental Health Sciences and Research Bureau, Environmental Health Centre, Ottawa, Ontario K1A0K9, Canada.
Fahd Al-MullaDepartment of Pathology, Kuwait University, Safat 13110, Kuwait.
Rabeah Al-TemaimiDepartment of Pathology, Kuwait University, Safat 13110, Kuwait.
Amedeo AmedeiDepartment of Experimental and Clinical Medicine, University of Firenze, Florence 50134, Italy.
Amaya AzquetaDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, University of Navarra, Pamplona 31009, Spain.
William H BissonEnvironmental and Molecular Toxicology, Environmental Health Sciences Center, Oregon State University, Corvallis, OR 97331, USA.
Dustin G BrownDepartment of Environmental and Radiological Health Sciences/Food Science and Human Nutrition, College of Veterinary Medicine and Biomedical Sciences, Colorado State University/Colorado School of Public Health, Fort Collins, CO 80523-1680, USA.
Gunnar BrunborgDepartment of Chemicals and Radiation, Division of Environmental Medicine, Norwegian Institute of Public Health, PO Box 4404, N-0403 Oslo, Norway.
Amelia K CharlesHopkins Building, School of Biological Sciences, University of Reading, Reading, Berkshire RG6 6UB, UK.
Tao ChenDivision of Genetic and Molecular Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA.
Annamaria ColacciCenter for Environmental Carcinogenesis and Risk Assessment, Environmental Protection and Health Prevention Agency, Bologna 40126, Italy.
Firouz DarroudiHuman and Environmental Safety Research, Department of Health Sciences, College of North Atlantic, Doha, State of Qatar.
Stefano ForteMediterranean Institute of Oncology, 95029 Viagrande, Italy.
Laetitia GonzalezLaboratory for Cell Genetics, Vrije Universiteit Brussel, Brussels 1050, Belgium.
Roslida A HamidDepartment of Biomedical Science, Faculty of Medicine and Health Sciences, University Putra, Serdang 43400, Selangor, Malaysia.
Lisbeth E KnudsenUniversity of Copenhagen, Department of Public Health, Copenhagen 1353, Denmark.
Luc LeynsLaboratory for Cell Genetics, Vrije Universiteit Brussel, Brussels 1050, Belgium.
Adela Lopez de Cerain SalsamendiDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, University of Navarra, Pamplona 31009, Spain.
Lorenzo MemeoMediterranean Institute of Oncology, 95029 Viagrande, Italy.
Chiara MondelloInstitute of Molecular Genetics, National Research Council, Pavia 27100, Italy.
Carmel MothersillMedical Physics & Applied Radiation Sciences, McMaster University, Hamilton, Ontario L8S4L8, Canada.
Ann-Karin OlsenDepartment of Chemicals and Radiation, Division of Environmental Medicine, Norwegian Institute of Public Health, PO Box 4404, N-0403 Oslo, Norway.
Sofia PavanelloDepartment of Cardiac, Thoracic and Vascular Sciences, Unit of Occupational Medicine, University of Padova, Padova 35128, Italy.
Jayadev RajuToxicology Research Division, Bureau of Chemical Safety Food Directorate, Health Products and Food Branch Health Canada, Ottawa, Ontario K1A0K9, Canada.
Emilio RojasDepartamento de Medicina Genomica y Toxicologia Ambiental, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de México, México CP 04510, México.
Rabindra RoyLombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA.
Elizabeth P RyanDepartment of Environmental and Radiological Health Sciences/Food Science and Human Nutrition, College of Veterinary Medicine and Biomedical Sciences, Colorado State University/Colorado School of Public Health, Fort Collins, CO 80523-1680, USA.
Patricia Ostrosky-WegmanDepartamento de Medicina Genomica y Toxicologia Ambiental, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de México, México CP 04510, México.
Hosni K SalemUrology Department, kasr Al-Ainy School of Medicine, Cairo University, El Manial, Cairo 12515, Egypt.
A Ivana ScovassiInstitute of Molecular Genetics, National Research Council, Pavia 27100, Italy.
Neetu SinghCentre for Advanced Research, King George's Medical University, Chowk, Lucknow 226003, Uttar Pradesh, India.
Monica VaccariCenter for Environmental Carcinogenesis and Risk Assessment, Environmental Protection and Health Prevention Agency, Bologna 40126, Italy.
Frederik J Van SchootenDepartment of Toxicology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University, 6200MD, PO Box 61, Maastricht, The Netherlands.
Mahara ValverdeDepartamento de Medicina Genomica y Toxicologia Ambiental, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de México, México CP 04510, México.
Jordan WoodrickLombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA.
Luoping ZhangDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720-7360, USA.
Nik van LarebekeLaboratory for Analytical and Environmental Chemistry, Vrije Universiteit Brussel, Brussels 1050, Belgium, Study Centre for Carcinogenesis and Primary Prevention of Cancer, Ghent University, Ghent 9000, Belgium;
Micheline Kirsch-VoldersLaboratory for Cell Genetics, Vrije Universiteit Brussel, Brussels 1050, Belgium.
Andrew R CollinsDepartment of Nutrition, University of Oslo, Oslo 0316, Norway.
Vrije Universiteit Brussel · BEColorado School of Public Health · USHealth Canada · CAKuwait University · KWNorwegian Institute of Public Health · NOUniversidad de Navarra · ESCairo University · EGFlemish Institute for Technological Research · BEGeorgetown University · USGeorgetown University Medical Center · USKing George's Medical University · INMcMaster University · CAOregon State University · USUnited States Food and Drug Administration · USUniversiti Putra Malaysia · MYUniversity of California, Berkeley · USUniversity of Oslo · NOUniversity of Padua · IT
Funding
TRAINING GRANT IN TUMOR BIOLOGYT32CA009686 · NCI · GEORGETOWN UNIVERSITY · PI ANNA Tate RIEGEL, DAVID J ROBBINS · 1996 to 2026
$10.8MRegulations of DNA Alkylation/Deamination Damage RepairR01CA092306 · NCI · INSTITUTE FOR CANCER PREVENTION · PI ROY, RABINDRA · 2003 to 2013
$2.8MDNA Repair of Endogenous Lesions in CarcinogenesisR01CA113447 · NCI · GEORGETOWN UNIVERSITY · PI ROY, RABINDRA · 2006 to 2010
$1.4MBiomarkers of Formaldehyde Exposure and ToxicityR01ES017452 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ZHANG, LUOPING · 2009 to 2010
$743kThe Halifax Project: Chemical Mixtures and CancerR13ES023276 · NIEHS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI CARPENTER, DAVID ORLO · 2013 to 2013
$25kNCI NIH HHS R01 CA092306NCI NIH HHS R01 CA113447NCI NIH HHS R01 CA92306NCI NIH HHS R01 CA92306-S1NCI NIH HHS T32 CA009686NIEHS NIH HHS R01ES017452NIEHS NIH HHS R13 ES023276
Abstract
Genome instability is a prerequisite for the development of cancer. It occurs when genome maintenance systems fail to safeguard the genome's integrity, whether as a consequence of inherited defects or induced via exposure to environmental agents (chemicals, biological agents and radiation). Thus, genome instability can be defined as an enhanced tendency for the genome to acquire mutations; ranging from changes to the nucleotide sequence to chromosomal gain, rearrangements or loss. This review raises the hypothesis that in addition to known human carcinogens, exposure to low dose of other chemicals present in our modern society could contribute to carcinogenesis by indirectly affecting genome stability. The selected chemicals with their mechanisms of action proposed to indirectly contribute to genome instability are: heavy metals (DNA repair, epigenetic modification, DNA damage signaling, telomere length), acrylamide (DNA repair, chromosome segregation), bisphenol A (epigenetic modification, DNA damage signaling, mitochondrial function, chromosome segregation), benomyl (chromosome segregation), quinones (epigenetic modification) and nano-sized particles (epigenetic pathways, mitochondrial function, chromosome segregation, telomere length). The purpose of this review is to describe the crucial aspects of genome instability, to outline the ways in which environmental chemicals can affect this cancer hallmark and to identify candidate chemicals for further study. The overall aim is to make scientists aware of the increasing need to unravel the underlying mechanisms via which chemicals at low doses can induce genome instability and thus promote carcinogenesis.
Indexed as
AnimalsCarcinogenesisCarcinogens, EnvironmentalEnvironmental ExposureGenomic InstabilityHazardous SubstancesHumansNeoplasmsCarcinogens, EnvironmentalHazardous Substances
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