Evidence map›Paper›PMID 26106142›Full record

ReviewCarcinogenesis2015

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead.

William H Goodson, Leroy Lowe, David O Carpenter, Michael Gilbertson, Abdul Manaf Ali, Adela Lopez de Cerain Salsamendi, Ahmed Lasfar, Amancio Carnero, Amaya Azqueta, Amedeo Amedei and 163 more

Erratum issuedOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Carcinogenesis, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 109 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed, 2 pooled it
13.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

109 citing papers in PubMed, 2 syntheses or guidelines pooled it, 315 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Dietary Risk of Neonicotinoids and Other Pesticides in Mexican Children Residing in Agroindustrial Zones.International journal of environmental research and public health · 2026
    Article
  4. Article
  5. Article
  6. Rethinking the microenvironment's role in chemical-induced malignancy.Toxicological sciences : an official journal of the Society of Toxicology · 2026
    Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. A gene set enrichment analysis for cancer hallmarks.Journal of pharmaceutical analysis · 2025
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Chemopreventive Potential ofPharmaceuticals (Basel, Switzerland) · 2024
    Article
  17. Review
  18. Review
  19. Article
  20. Article

49 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

173 authors at 20 institutions in 30 countries.

William H GoodsonCalifornia Pacific Medical Center Research Institute, 2100 Webster Street #401, San Francisco, CA 94115, USA, Getting to Know Cancer, Room 229A, 36 Arthur Street, Truro, Nova Scotia B2N 1X5, Canada, Lancaster Environment Centre, Lancaster University, Bailrigg, Lancaster LA1 4AP, UK, Institute for Health and the Environment, University at Albany, 5 University Pl., Rensselaer, NY 12144, USA, Getting to Know Cancer, Guelph N1G 1E4, Canada, School of Biotechnology, Faculty of Agriculture Biotechnology and Food Sciences, Sultan Zainal Abidin University, Tembila Campus, 22200 Besut, Terengganu, Malaysia, Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Navarra, Pamplona 31008, Spain, Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers, State University of New Jersey, Piscataway, NJ 08854, USA, Instituto de Biomedicina de Sevilla, Consejo Superior de Investigaciones Cientificas. Hospital Universitario Virgen del Rocio, Univ. de Sevilla., Avda Manuel Siurot sn. 41013 Sevilla, Spain, Department of Experimental and Clinical Medicine, University of Firenze, Florence 50134, Italy, School of Biological Sciences, University of Reading, Hopkins Building, Reading, Berkshire RG6 6UB, UK, Department of Nutrition, University of Oslo, Oslo, Norway, Department of Biochemistry and Biology, University of Bath, Claverton Down, Bath BA2 7AY, UK, Department of Public Health Sciences, College of Medicine, Pennsylvania State University, Hershey, PA 17033, USA, Center for Environmental Carcinogenesis and Risk Assessment, Environmental Protection and Health Prevention Agency, 40126 Bologna, Italy, Department of Chemicals and Radiation, Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo N-0403, Norway, Planet Biotechnologies Inc., St Albert, Alberta T8N 5K4, Canada, Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY 40508, USA, Spanish National Cancer Research Centre, CNI
Leroy LoweGetting to Know Cancer, Room 229A, 36 Arthur Street, Truro, Nova Scotia B2N 1X5, Canada, Lancaster Environment Centre, Lancaster University, Bailrigg, Lancaster LA1 4AP, UK.
David O CarpenterInstitute for Health and the Environment, University at Albany, 5 University Pl., Rensselaer, NY 12144, USA.
Michael GilbertsonGetting to Know Cancer, Guelph N1G 1E4, Canada.
Abdul Manaf AliSchool of Biotechnology, Faculty of Agriculture Biotechnology and Food Sciences, Sultan Zainal Abidin University, Tembila Campus, 22200 Besut, Terengganu, Malaysia.
Adela Lopez de Cerain SalsamendiDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, University of Navarra, Pamplona 31008, Spain.
Ahmed LasfarDepartment of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers, State University of New Jersey, Piscataway, NJ 08854, USA.
Amancio CarneroInstituto de Biomedicina de Sevilla, Consejo Superior de Investigaciones Cientificas. Hospital Universitario Virgen del Rocio, Univ. de Sevilla., Avda Manuel Siurot sn. 41013 Sevilla, Spain.
Amaya AzquetaDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, University of Navarra, Pamplona 31008, Spain.
Amedeo AmedeiDepartment of Experimental and Clinical Medicine, University of Firenze, Florence 50134, Italy.
Amelia K CharlesSchool of Biological Sciences, University of Reading, Hopkins Building, Reading, Berkshire RG6 6UB, UK.
Andrew R CollinsDepartment of Nutrition, University of Oslo, Oslo, Norway.
Andrew WardDepartment of Biochemistry and Biology, University of Bath, Claverton Down, Bath BA2 7AY, UK.
Anna C SalzbergDepartment of Public Health Sciences, College of Medicine, Pennsylvania State University, Hershey, PA 17033, USA.
Annamaria ColacciCenter for Environmental Carcinogenesis and Risk Assessment, Environmental Protection and Health Prevention Agency, 40126 Bologna, Italy.
Ann-Karin OlsenDepartment of Chemicals and Radiation, Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo N-0403, Norway.
Arthur BergDepartment of Public Health Sciences, College of Medicine, Pennsylvania State University, Hershey, PA 17033, USA.
Barry J BarclayPlanet Biotechnologies Inc., St Albert, Alberta T8N 5K4, Canada.
Binhua P ZhouDepartment of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY 40508, USA.
Carmen Blanco-AparicioSpanish National Cancer Research Centre, CNIO, Melchor Fernandez Almagro, 3, 28029 Madrid, Spain.
Carolyn J BagloleDepartment of Medicine, McGill University, Montreal, Quebec H4A 3J1, Canada.
Chenfang DongDepartment of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY 40508, USA.
Chiara MondelloIstituto di Genetica Molecolare, CNR, Via Abbiategrasso 207, 27100 Pavia, Italy.
Chia-Wen HsuDivision of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3375, USA.
Christian C NausDepartment of Cellular and Physiological Sciences, Life Sciences Institute, Faculty of Medicine, The University of British Columbia, Vancouver, British Columbia V5Z 1M9, Canada.
Clement YedjouDepartment of Biology, Jackson State University, Jackson, MS 39217, USA.
Colleen S CurranDepartment of Molecular and Environmental Toxicology, University of Wisconsin-Madison, Madison, WI 53706, USA.
Dale W LairdDepartment of Anatomy and Cell Biology, University of Western Ontario, London, Ontario N6A 3K7, Canada.
Daniel C KochStanford University Department of Medicine, Division of Oncology, Stanford, CA 94305, USA.
Danielle J CarlinSuperfund Research Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27560, USA.
Dean W FelsherDepartment of Medicine, Oncology and Pathology, Stanford University, Stanford, CA 94305, USA.
Debasish RoyDepartment of Natural Science, The City University of New York at Hostos Campus, Bronx, NY 10451, USA.
Dustin G BrownDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523-1680, USA.
Edward RatovitskiDepartment of Head and Neck Surgery/Head and Neck Cancer Research, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Elizabeth P RyanDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523-1680, USA.
Emanuela CorsiniDepartment of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20133 Milan, Italy.
Emilio RojasDepartment of Genomic Medicine and Environmental Toxicology, Institute for Biomedical Research, National Autonomous University of Mexico, Mexico City 04510, México.
Eun-Yi MoonDepartment of Bioscience and Biotechnology, Sejong University, Seoul 143-747, Korea.
Ezio LaconiDepartment of Biomedical Sciences, University of Cagliari, 09124 Cagliari, Italy.
Fabio MarongiuDepartment of Biomedical Sciences, University of Cagliari, 09124 Cagliari, Italy.
Fahd Al-MullaDepartment of Pathology, Kuwait University, Safat 13110, Kuwait.
Ferdinando ChiaradonnaDepartment of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milan, Italy, SYSBIO Centre of Systems Biology, Department of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milan, Italy.
Firouz DarroudiHuman Safety and Environmental Research, Department of Health Sciences, College of North Atlantic, Doha 24449, State of Qatar.
Francis L MartinLancaster Environment Centre, Lancaster University, Bailrigg, Lancaster LA1 4AP, UK.
Frederik J Van SchootenDepartment of Toxicology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University, Maastricht 6200, The Netherlands.
Gary S GoldbergDepartment of Molecular Biology, School of Osteopathic Medicine, Rowan University, Stratford, NJ 08084, USA.
Gerard WagemakerHacettepe University, Center for Stem Cell Research and Development, Ankara 06640, Turkey.
Gladys N NangamiDepartment of Biochemistry and Cancer Biology, Meharry Medical College, Nashville, TN 37208, USA.
Gloria M CalafCenter for Radiological Research, Columbia University Medical Center, New York, NY 10032, USA, Instituto de Alta Investigacion, Universidad de Tarapaca, Arica, Chile.
Graeme WilliamsSchool of Biological Sciences, University of Reading, Reading, RG6 6UB, UK.
Gregory T WolfDepartment of Otolaryngology - Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Gudrun KoppenEnvironmental Risk and Health Unit, Flemish Institute for Technological Research, 2400 Mol, Belgium.
Gunnar BrunborgDepartment of Chemicals and Radiation, Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo N-0403, Norway.
H Kim LyerlyDepartment of Surgery, Pathology, Immunology, Duke University Medical Center, Durham, NC 27710, USA.
Harini KrishnanDepartment of Molecular Biology, School of Osteopathic Medicine, Rowan University, Stratford, NJ 08084, USA.
Hasiah Ab HamidDepartment of Biomedical Sciences, Faculty of Medicine and Health Sciences, 43400 Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
Hemad YasaeiDepartment of Life Sciences, College of Health and Life Sciences and the Health and Environment Theme, Institute of Environment, Health and Societies, Brunel University Kingston Lane, Uxbridge, Middlesex UB8 3PH, UK.
Hideko SoneNational Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibraki 3058506, Japan.
Hiroshi KondohDepartment of Geriatric Medicine, Kyoto University Hospital 54 Kawaharacho, Shogoin, Sakyo-ku Kyoto, 606-8507, Japan.
Hosni K SalemDepartment of Urology, Kasr Al-Ainy School of Medicine, Cairo University, El Manial, Cairo 11559, Egypt.
Hsue-Yin HsuDepartment of Life Sciences, Tzu-Chi University, Hualien 970, Taiwan.
Hyun Ho ParkSchool of Biotechnology, Yeungnam University, Gyeongbuk 712-749, South Korea.
Igor KoturbashDepartment of Environmental and Occupational Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Isabelle R MiousseDepartment of Environmental and Occupational Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
A Ivana ScovassiIstituto di Genetica Molecolare, CNR, Via Abbiategrasso 207, 27100 Pavia, Italy.
James E KlaunigDepartment of Environmental Health, Indiana University, School of Public Health, Bloomington, IN 47405, USA.
Jan VondráčekDepartment of Cytokinetics, Institute of Biophysics Academy of Sciences of the Czech Republic, Brno, CZ-61265, Czech Republic.
Jayadev RajuRegulatory Toxicology Research Division, Bureau of Chemical Safety, Food Directorate, Health Canada, Ottawa, Ontario K1A 0K9, Canada.
Jesse RomanDepartment of Medicine, University of Louisville, Louisville, KY 40202, USA, Robley Rex VA Medical Center, Louisville, KY 40202, USA.
John Pierce WiseDepartment of Applied Medical Sciences, University of Southern Maine, 96 Falmouth St., Portland, ME 04104, USA.
Jonathan R WhitfieldMouse Models of Cancer Therapies Group, Vall d'Hebron Institute of Oncology (VHIO), 08035 Barcelona, Spain.
Jordan WoodrickLombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington DC 20057, USA.
Joseph A ChristopherCancer Research UK. Cambridge Institute, University of Cambridge, Robinson Way, Cambridge CB2 0RE, UK.
Josiah OchiengDepartment of Biochemistry and Cancer Biology, Meharry Medical College, Nashville, TN 37208, USA.
Juan Fernando Martinez-LealDepartment of Cell Biology, Pharmamar-SAU, Avda. De los Reyes, 1. 28770-Colmenar Viejo, Madrid, Spain.
Judith WeiszDepartments of Obstetrics and Gynecology and Pathology, Pennsylvania State University College of Medicine, Hershey PA 17033, USA.
Julia KravchenkoDepartment of Surgery, Pathology, Immunology, Duke University Medical Center, Durham, NC 27710, USA.
Jun SunDepartment of Biochemistry, Rush University, Chicago, IL 60612, USA.
Kalan R PrudhommeEnvironmental and Molecular Toxicology, Environmental Health Science Center, Oregon State University, Corvallis, OR 97331, USA.
Kannan Badri NarayananSchool of Biotechnology, Yeungnam University, Gyeongbuk 712-749, South Korea.
Karine A Cohen-SolalDepartment of Medicine/Medical Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08903, USA.
Kim MoorwoodDepartment of Biochemistry and Biology, University of Bath, Claverton Down, Bath BA2 7AY, UK.
Laetitia GonzalezLaboratory for Cell Genetics, Vrije Universiteit Brussel, 1050 Brussels, Belgium.
Laura SoucekMouse Models of Cancer Therapies Group, Vall d'Hebron Institute of Oncology (VHIO), 08035 Barcelona, Spain, Catalan Institution for Research and Advanced Studies (ICREA), Barcelona 08010, Spain.
Le JianSchool of Public Health, Curtin University, Bentley, WA 6102, Australia, Department of Urology, University of California Davis, Sacramento, CA 95817, USA.
Leandro S D'AbronzoDepartment of Urology, University of California Davis, Sacramento, CA 95817, USA.
Liang-Tzung LinDepartment of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Lin LiSchool of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, The People's Republic of China.
Linda GulliverFaculty of Medicine, University of Otago, Dunedin 9054, New Zealand.
Lisa J McCawleyDepartment of Biomedical Engineering and Cancer Biology, Vanderbilt University, Nashville, TN 37235, USA.
Lorenzo MemeoDepartment of Experimental Oncology, Mediterranean Institute of Oncology, Via Penninazzo 7, Viagrande (CT) 95029, Italy.
Louis VermeulenCenter for Experimental Molecular Medicine, Academic Medical Center, Meibergdreef 9, Amsterdam 1105 AZ, The Netherlands.
Luc LeynsLaboratory for Cell Genetics, Vrije Universiteit Brussel, 1050 Brussels, Belgium.
Luoping ZhangDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720-7360, USA.
Mahara ValverdeDepartment of Genomic Medicine and Environmental Toxicology, Institute for Biomedical Research, National Autonomous University of Mexico, Mexico City 04510, México.
Mahin KhatamiInflammation and Cancer Research, National Cancer Institute (NCI) (Retired), National Institutes of Health, Bethesda, MD 20892, USA.
Maria Fiammetta RomanoDepartment of Molecular Medicine and Medical Biotechnology, Federico II University of Naples, 80131 Naples, Italy.
Marion ChapellierCentre De Recherche En Cancerologie, De Lyon, Lyon, U1052-UMR5286, France.
Marc A WilliamsUnited States Army Institute of Public Health, Toxicology Portfolio-Health Effects Research Program, Aberdeen Proving Ground, Edgewood, MD 21010-5403, USA.
Mark WadeCenter for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia, Via Adamello 16, 20139 Milano, Italy.
Masoud H ManjiliDepartment of Microbiology and Immunology, Virginia Commonwealth University, Massey Cancer Center, Richmond, VA 23298, USA.
Matilde E LleonartInstitut De Recerca Hospital Vall D'Hebron, Passeig Vall d'Hebron, 119-129, 08035 Barcelona, Spain.
Menghang XiaDivision of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3375, USA.
Michael J GonzalezUniversity of Puerto Rico, Medical Sciences Campus, School of Public Health, Nutrition Program, San Juan 00921, Puerto Rico.
Michalis V KaramouzisDepartment of Biological Chemistry, Medical School, University of Athens, Institute of Molecular Medicine and Biomedical Research, 10676 Athens, Greece.
Micheline Kirsch-VoldersLaboratory for Cell Genetics, Vrije Universiteit Brussel, 1050 Brussels, Belgium.
Monica VaccariCenter for Environmental Carcinogenesis and Risk Assessment, Environmental Protection and Health Prevention Agency, 40126 Bologna, Italy.
Nancy B KuemmerleGeisel School of Medicine at Dartmouth, Hanover, NH 03755, USA, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.
Neetu SinghAdvanced Molecular Science Research Centre (Centre for Advanced Research), King George's Medical University, Lucknow, Uttar Pradesh 226 003, India.
Nichola CruickshanksDepartments of Neurosurgery and Biochemistry and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA.
Nicole KleinstreuerIntegrated Laboratory Systems Inc., in support of the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, RTP, NC 27709, USA.
Nik van LarebekeAnalytische, Milieu en Geochemie, Vrije Universiteit Brussel, Brussel B1050, Belgium.
Nuzhat AhmedDepartment of Obstetrics and Gynecology, University of Melbourne, Victoria 3052, Australia.
Olugbemiga OgunkuaDepartment of Biochemistry and Cancer Biology, Meharry Medical College, Nashville, TN 37208, USA.
P K KrishnakumarCenter for Environment and Water, Research Institute, King Fahd University of Petroleum and Minerals, Dhahran 3126, Saudi Arabia .
Pankaj VadgamaSchool of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London, E1 4NS, UK.
Paola A MarignaniDepartment of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada.
Paramita M GhoshDepartment of Urology, University of California Davis, Sacramento, CA 95817, USA.
Patricia Ostrosky-WegmanDepartment of Genomic Medicine and Environmental Toxicology, Institute for Biomedical Research, National Autonomous University of Mexico, Mexico City 04510, México.
Patricia A ThompsonDepartment of Pathology, Stony Brook School of Medicine, Stony Brook University, The State University of New York, Stony Brook, NY 11794-8691, USA.
Paul DentDepartments of Neurosurgery and Biochemistry and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA.
Petr HenebergCharles University in Prague, Third Faculty of Medicine, CZ-100 00 Prague 10, Czech Republic.
Philippa DarbreSchool of Biological Sciences, The University of Reading, Whiteknights, Reading RG6 6UB, England.
Po Sing LeungSchool of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, The People's Republic of China.
Pratima Nangia-MakkerDepartment of Pathology, Wayne State University, Detroit, MI 48201, USA.
Qiang Shawn ChengComputer Science Department, Southern Illinois University, Carbondale, IL 62901, USA.
R Brooks RobeyWhite River Junction Veterans Affairs Medical Center, White River Junction, VT 05009, USA, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.
Rabeah Al-TemaimiHuman Genetics Unit, Department of Pathology, Faculty of Medicine, Kuwait University, Jabriya 13110, Kuwait.
Rabindra RoyLombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington DC 20057, USA.
Rafaela Andrade-VieiraDepartment of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada.
Ranjeet K SinhaDepartment of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.
Rekha MehtaRegulatory Toxicology Research Division, Bureau of Chemical Safety, Food Directorate, Health Canada, Ottawa, Ontario K1A 0K9, Canada.
Renza VentoDepartment of Biological, Chemical, and Pharmaceutical Sciences and Technologies, Polyclinic Plexus, University of Palermo, Palermo 90127, Italy , Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, PA 19122, USA.
Riccardo Di FioreDepartment of Biological, Chemical, and Pharmaceutical Sciences and Technologies, Polyclinic Plexus, University of Palermo, Palermo 90127, Italy .
Richard Ponce-CusiInstituto de Alta Investigacion, Universidad de Tarapaca, Arica, Chile.
Rita Dornetshuber-FleissDepartment of Pharmacology and Toxicology, University of Vienna, Vienna A-1090, Austria, Institute of Cancer Research, Department of Medicine, Medical University of Vienna, Wien 1090, Austria.
Rita NahtaDepartments of Pharmacology and Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, GA 30322, USA.
Robert C CastellinoDivision of Hematology and Oncology, Department of Pediatrics, Children's Healthcare of Atlanta, GA 30322, USA, Department of Pediatrics, Emory University School of Medicine, Emory University, Atlanta, GA 30322, USA.
Roberta PaloriniDepartment of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milan, Italy, SYSBIO Centre of Systems Biology, Department of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milan, Italy.
Roslida Abd HamidDepartment of Biomedical Sciences, Faculty of Medicine and Health Sciences, 43400 Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
Sabine A S LangieEnvironmental Risk and Health Unit, Flemish Institute for Technological Research, 2400 Mol, Belgium.
Sakina E EltomDepartment of Biochemistry and Cancer Biology, Meharry Medical College, Nashville, TN 37208, USA.
Samira A BrooksLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC 27599, USA.
Sandra RyeomDepartment of Cancer Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Sandra S WiseDepartment of Applied Medical Sciences, University of Southern Maine, 96 Falmouth St., Portland, ME 04104, USA.
Sarah N BayProgram in Genetics and Molecular Biology, Graduate Division of Biological and Biomedical Sciences, Emory University, Atlanta, GA 30322, USA.
Shelley A HarrisPopulation Health and Prevention, Research, Prevention and Cancer Control, Cancer Care Ontario, Toronto, Ontario, M5G 2L7, Canada, Departments of Epidemiology and Occupational and Environmental Health, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, M5T 3M7, Canada .
Silvana PapagerakisDepartment of Otolaryngology - Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Simona RomanoDepartment of Molecular Medicine and Medical Biotechnology, Federico II University of Naples, 80131 Naples, Italy.
Sofia PavanelloDepartment of Cardiac, Thoracic and Vascular Sciences, Unit of Occupational Medicine, University of Padova, Padova 35128, Italy.
Staffan ErikssonDepartment of Anatomy, Physiology and Biochemistry, The Swedish University of Agricultural Sciences, PO Box 7011, VHC, Almas Allé 4, SE-756 51, Uppsala, Sweden.
Stefano ForteDepartment of Experimental Oncology, Mediterranean Institute of Oncology, Via Penninazzo 7, Viagrande (CT) 95029, Italy.
Stephanie C CaseyStanford University Department of Medicine, Division of Oncology, Stanford, CA 94305, USA.
Sudjit LuanpitpongSiriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
Tae-Jin LeeDepartment of Anatomy, College of Medicine, Yeungnam University, Daegu 705-717, South Korea.
Takemi OtsukiDepartment of Hygiene, Kawasaki Medical School, Matsushima Kurashiki, Okayama 701-0192, Japan.
Tao ChenDivision of Genetic and Molecular Toxicology, National Center for Toxicological Research, United States Food and Drug Administration, Jefferson, AR 72079, USA.
Thierry MassfelderINSERM U1113, team 3 'Cell Signalling and Communication in Kidney and Prostate Cancer', University of Strasbourg, Faculté de Médecine, 67085 Strasbourg, France.
Thomas SandersonINRS-Institut Armand-Frappier, 531 Boulevard des Prairies, Laval, QC H7V 1B7, Canada.
Tiziana GuarnieriDepartment of Biology, Geology and Environmental Sciences, Alma Mater Studiorum Università di Bologna, Via Francesco Selmi, 3, 40126 Bologna, Italy, Center for Applied Biomedical Research, S. Orsola-Malpighi University Hospital, Via Massarenti, 9, 40126 Bologna, Italy, National Institute of Biostructures and Biosystems, Viale Medaglie d' Oro, 305, 00136 Roma, Italy.
Tove HultmanDepartment of Biosciences and Veterinary Public Health, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, PO Box 7028, 75007 Uppsala, Sweden.
Valérian DormoyINSERM U1113, team 3 'Cell Signalling and Communication in Kidney and Prostate Cancer', University of Strasbourg, Faculté de Médecine, 67085 Strasbourg, France, Department of Cell and Developmental Biology, University of California, Irvine, CA 92697, USA.
Valerie Odero-MarahDepartment of Biology/Center for Cancer Research and Therapeutic Development, Clark Atlanta University, Atlanta, GA 30314, USA.
Venkata SabbisettiHarvard Medical School/Brigham and Women's Hospital, Boston, MA 02115, USA.
Veronique Maguer-SattaUnited States Army Institute of Public Health, Toxicology Portfolio-Health Effects Research Program, Aberdeen Proving Ground, Edgewood, MD 21010-5403, USA.
W Kimryn RathmellLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC 27599, USA.
Wilhelm EngströmDepartment of Biosciences and Veterinary Public Health, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, PO Box 7028, 75007 Uppsala, Sweden.
William K DeckerBaylor College of Medicine, Houston, TX 77030, USA.
William H BissonEnvironmental and Molecular Toxicology, Environmental Health Science Center, Oregon State University, Corvallis, OR 97331, USA.
Yon RojanasakulDepartment of Pharmaceutical Sciences, West Virginia University, Morgantown, WV, 26506, USA.
Yunus LuqmaniDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Kuwait University, PO Box 24923, Safat 13110, Kuwait and.
Zhenbang ChenDepartment of Biochemistry and Cancer Biology, Meharry Medical College, Nashville, TN 37208, USA.
Zhiwei HuDepartment of Surgery, The Ohio State University College of Medicine, The James Comprehensive Cancer Center, Columbus, OH 43210, USA.
Meharry Medical College · USVrije Universiteit Brussel · BEKuwait University · KWLancaster University · GBPennsylvania State University · USStanford University · USSwedish University of Agricultural Sciences · SEUniversidad Nacional Autónoma de México · MXUniversity of California, Davis · USUniversity of Reading · GBVirginia Commonwealth University · USYeungnam University · KRChinese University of Hong Kong · HKColorado State University · USDalhousie University · CAFlemish Institute for Technological Research · BEGeorgetown University Medical Center · USHealth Canada · CAIstituto di Genetica Molecolare · ITNational Center for Advancing Translational Sciences · US

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Jennifer A. Woyach · 1985 to 2026
$132.3M
Training and Mentoring Core P20GM103476 · NIGMS · UNIVERSITY OF SOUTHERN MISSISSIPPI · PI Vijay Rangachari · 2012 to 2026
$60.2M
Technologies and Resources CoreU54MD007593 · NIMHD · MEHARRY MEDICAL COLLEGE · PI ADUNYAH, SAMUEL EVANS · 2012 to 2018
$24.7M
Reducing Susceptibility to Environmental Stress Throughout the Life SpanP30ES000210 · NIEHS · OREGON STATE UNIVERSITY · PI BECKMAN, JOSEPH S · 1985 to 2015
$21.4M
Translational Pathology CoreU54CA163069 · NCI · MEHARRY MEDICAL COLLEGE · PI ADUNYAH, SAMUEL EVANS · 2011 to 2025
$18.8M
Small Animal ImagingP50CA114747 · NCI · STANFORD UNIVERSITY · PI CONTAG, CHRISTOPHER H · 2005 to 2014
$18.2M
THEORY OF PLANNED BEHAVIOR VS ETHNICITY /PHYSICAL ACTIVIG12RR003062 · NCRR · CLARK ATLANTA UNIVERSITY · PI ODERO-MARAH, VALERIE · 1985 to 2011
$15.5M
TOXICOLOGYT32ES007126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ILONA JASPERS, Bernard E. Weissman · 1985 to 2026
$13.0M
Pilot ProjectsU54CA151459 · NCI · STANFORD UNIVERSITY · PI GAMBHIR, SANJIV S · 2010 to 2014
$12.6M
MODELING THE ROLE OF PROGRESSION IN FOLLICULAR LYMPHOMAU54CA149145 · NCI · STANFORD UNIVERSITY · PI PLEVRITIS, SYLVIA KATINA · 2010 to 2014
$12.1M
RCMI-Center for Environmental HealthG12MD007581 · NIMHD · JACKSON STATE UNIVERSITY · PI TCHOUNWOU, PAUL B. · 2012 to 2017
$11.2M
TRAINING GRANT IN TUMOR BIOLOGYT32CA009686 · NCI · GEORGETOWN UNIVERSITY · PI ANNA Tate RIEGEL, DAVID J ROBBINS · 1996 to 2026
$10.8M
Cancer Research UKCIHR MOP-115019Medical Research Council MR/L007215/1NCATS NIH HHS KL2 TR000063NCATS NIH HHS KL2TR000063NCATS NIH HHS UL1 TR000039NCATS NIH HHS UL1TR000039NCI NIH HHS CA116812NCI NIH HHS CA163069NCI NIH HHS CA92306NCI NIH HHS P30 CA016058NCI NIH HHS P50 CA114747NCI NIH HHS R01 CA061774NCI NIH HHS R01 CA092306NCI NIH HHS R01 CA113447NCI NIH HHS R01 CA116812NCI NIH HHS R01 CA118374NCI NIH HHS R01-CA141704NCI NIH HHS R01 CA150214NCI NIH HHS R01-CA150214NCI NIH HHS R01 CA170378NCI NIH HHS R01 CA170378 PQ22NCI NIH HHS R01 CA184384NCI NIH HHS R01 CA192613NCI NIH HHS R01-CA61774NCI NIH HHS R01 CA92306-S1NCI NIH HHS R21 CA169964NCI NIH HHS SC1 CA153326NCI NIH HHS SC1CA153326NCI NIH HHS T32 CA009151NCI NIH HHS T32 CA009686NCI NIH HHS T32CA09151NCI NIH HHS U54 CA149145NCI NIH HHS U54 CA151459NCRR NIH HHS G12 RR003062NEI NIH HHS R21 EY037451NIDDK NIH HHS K01 DK075386NIDDK NIH HHS R01 DK052825NIDDK NIH HHS R01 DK105118NIDDK NIH HHS R01-DK52825NIDDK NIH HHS R03 DK089010NIEHS NIH HHS ES016893NIEHS NIH HHS N01 ES035504NIEHS NIH HHS N01-ES35504NIEHS NIH HHS P30 ES000210NIEHS NIH HHS R01 ES016893NIEHS NIH HHS R01 ES022968NIEHS NIH HHS R01-ES022968NIEHS NIH HHS R13 ES023276NIEHS NIH HHS R13ES023276NIEHS NIH HHS T32 ES007126NIGMS NIH HHS P20 GM103476NIMHD NIH HHS G12 MD007581NIMHD NIH HHS G12MD007581NIMHD NIH HHS G12 MD007590NIMHD NIH HHS MD004038NIMHD NIH HHS MD007593NIMHD NIH HHS U54 MD007593PHS HHS HHSN27320140003C
6 · The paper itself

Abstract

Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Cancer (IARC) suggest that the fraction of cancers attributable to toxic environmental exposures is between 7% and 19%. To explore the hypothesis that low-dose exposures to mixtures of chemicals in the environment may be combining to contribute to environmental carcinogenesis, we reviewed 11 hallmark phenotypes of cancer, multiple priority target sites for disruption in each area and prototypical chemical disruptors for all targets, this included dose-response characterizations, evidence of low-dose effects and cross-hallmark effects for all targets and chemicals. In total, 85 examples of chemicals were reviewed for actions on key pathways/mechanisms related to carcinogenesis. Only 15% (13/85) were found to have evidence of a dose-response threshold, whereas 59% (50/85) exerted low-dose effects. No dose-response information was found for the remaining 26% (22/85). Our analysis suggests that the cumulative effects of individual (non-carcinogenic) chemicals acting on different pathways, and a variety of related systems, organs, tissues and cells could plausibly conspire to produce carcinogenic synergies. Additional basic research on carcinogenesis and research focused on low-dose effects of chemical mixtures needs to be rigorously pursued before the merits of this hypothesis can be further advanced. However, the structure of the World Health Organization International Programme on Chemical Safety 'Mode of Action' framework should be revisited as it has inherent weaknesses that are not fully aligned with our current understanding of cancer biology.

Indexed as

AnimalsCarcinogenesisCarcinogens, EnvironmentalEnvironmental ExposureHazardous SubstancesHumansNeoplasmsCarcinogens, EnvironmentalHazardous Substances

Identifiers

PMID26106142
PMCPMC4480130
OpenAlexW2412214305

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Read underepoch 390

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.