ReviewCarcinogenesis2015
Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression.
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In one paragraph
Review in Carcinogenesis, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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27citing papers in PubMed, 1 pooled it
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What it found
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Chemical carcinogen safety testing: OECD expert group international consensus on the development of an integrated approach for the testing and assessment of chemical non-genotoxic carcinogens.Archives of toxicology · 2020Guideline
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- Lung cancer associated with combustion particles and fine particulate matter (PMBiochemical pharmacology · 2023Review
- Regulatory miRNAs, circRNAs and lncRNAs in cell cycle progression of breast cancer.Functional & integrative genomics · 2023Review
- Dimeric Benzodiazepines as Peptide Mimetics to Overcome p53-Dependent Drug Resistance of Tumors.Biomolecules · 2023Article
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- Integration of Epigenetic Mechanisms into Non-Genotoxic Carcinogenicity Hazard Assessment: Focus on DNA Methylation and Histone Modifications.International journal of molecular sciences · 2021Review
- Ceramide/protein phosphatase 2A axis is engaged in gap junction impairment elicited by PCB153 in liver stem-like progenitor cells.Molecular and cellular biochemistry · 2021Article
- Impact of circulating miRNA-373 on breast cancer diagnosis through targeting VEGF and cyclin D1 genes.Journal, genetic engineering & biotechnology · 2021Article
- Immune and Nervous Systems Interaction in Endocrine Disruptors Toxicity: The Case of Atrazine.Frontiers in toxicology · 2021Review
- Two-stage 3-methylcholanthrene and butylated hydroxytoluene-induced lung carcinogenesis in mice.Methods in cell biology · 2021Article
- The Key Characteristics of Carcinogens: Relationship to the Hallmarks of Cancer, Relevant Biomarkers, and Assays to Measure Them.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020Article
- Airborne PAHs inhibit gap junctional intercellular communication and activate MAPKs in human bronchial epithelial cell line.Environmental toxicology and pharmacology · 2020Article
- Effect of estrogen-active compounds on the expression of RACK1 and immunological implications.Archives of toxicology · 2020Article
- Curation of cancer hallmark-based genes and pathways for in silico characterization of chemical carcinogenesis.Database : the journal of biological databases and curation · 2020Article
- The Regulatory Role of MicroRNAs in Breast Cancer.International journal of molecular sciences · 2019Review
- Review
- Early Mechanistic Events Induced by Low Molecular Weight Polycyclic Aromatic Hydrocarbons in Mouse Lung Epithelial Cells: A Role for Eicosanoid Signaling.Toxicological sciences : an official journal of the Society of Toxicology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
38 authors.
Rita NahtaDepartments of Pharmacology and Hematology & Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, GA 30322, USA, Department of Pathology, Kuwait University, Safat 13110, Kuwait, Department of Experimental and Clinical Medicine, University of Firenze, 50134 Florence, Italy, Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada, Program in Genetics and Molecular Biology, Graduate Division of Biological and Biomedical Sciences, Emory University, Atlanta, GA 30322, USA, Department of Environmental and Radiological Health Sciences/Colorado State University/Colorado School of Public Health, Fort Collins, CO 80523-1680, USA, Center for Radiological Research, Columbia University Medical Center, New York, NY 10032, USA, Instituto de Alta Investigacion, Universidad de Tarapaca, Arica 8097877, Chile, Division of Hematology and Oncology, Department of Pediatrics, Children's Healthcare of Atlanta and Emory University, Atlanta, GA 30322, USA, Department of Medicine/Medical Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08901-1914, USA, Center for Environmental Carcinogenesis and Risk Assessment, Environmental Protection and Health Prevention Agency, Bologna 40126, Italy, Departments of Neurosurgery and Biochemistry and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 980033, USA, Department of Biological, Chemical, and Pharmaceutical Sciences and Technologies, Polyclinic Plexus, University of Palermo, 90127 Palermo, Italy, Mediterranean Institute of Oncology, 95029 Viagrande, Italy, Graduate School of Biomedical Sciences and Department of Molecular Biology, School of Osteopathic Medicine, Rowan University, Stratford, NJ 08084-1501, USA, Department of Biomedical Science, Faculty of Medicine and Health Sciences, University Putra, Serdang, Selangor 43400, Malaysia, Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontari
Fahd Al-MullaDepartment of Pathology, Kuwait University, Safat 13110, Kuwait.
Rabeah Al-TemaimiDepartment of Pathology, Kuwait University, Safat 13110, Kuwait.
Amedeo AmedeiDepartment of Experimental and Clinical Medicine, University of Firenze, 50134 Florence, Italy.
Rafaela Andrade-VieiraDepartment of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada.
Sarah N BayProgram in Genetics and Molecular Biology, Graduate Division of Biological and Biomedical Sciences, Emory University, Atlanta, GA 30322, USA.
Dustin G BrownDepartment of Environmental and Radiological Health Sciences/Colorado State University/Colorado School of Public Health, Fort Collins, CO 80523-1680, USA.
Gloria M CalafCenter for Radiological Research, Columbia University Medical Center, New York, NY 10032, USA, Instituto de Alta Investigacion, Universidad de Tarapaca, Arica 8097877, Chile.
Robert C CastellinoDivision of Hematology and Oncology, Department of Pediatrics, Children's Healthcare of Atlanta and Emory University, Atlanta, GA 30322, USA.
Karine A Cohen-SolalDepartment of Medicine/Medical Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08901-1914, USA.
Annamaria ColacciCenter for Environmental Carcinogenesis and Risk Assessment, Environmental Protection and Health Prevention Agency, Bologna 40126, Italy.
Nichola CruickshanksDepartments of Neurosurgery and Biochemistry and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 980033, USA.
Paul DentDepartments of Neurosurgery and Biochemistry and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 980033, USA.
Riccardo Di FioreDepartment of Biological, Chemical, and Pharmaceutical Sciences and Technologies, Polyclinic Plexus, University of Palermo, 90127 Palermo, Italy.
Stefano ForteMediterranean Institute of Oncology, 95029 Viagrande, Italy.
Gary S GoldbergGraduate School of Biomedical Sciences and Department of Molecular Biology, School of Osteopathic Medicine, Rowan University, Stratford, NJ 08084-1501, USA.
Roslida A HamidDepartment of Biomedical Science, Faculty of Medicine and Health Sciences, University Putra, Serdang, Selangor 43400, Malaysia.
Harini KrishnanGraduate School of Biomedical Sciences and Department of Molecular Biology, School of Osteopathic Medicine, Rowan University, Stratford, NJ 08084-1501, USA.
Dale W LairdDepartment of Anatomy and Cell Biology, University of Western Ontario, London, Ontario N6A 5C1, Canada.
Ahmed LasfarDepartment of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers, the State University of New Jersey, Piscataway, NJ 60503, USA.
Paola A MarignaniDepartment of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada.
Lorenzo MemeoMediterranean Institute of Oncology, 95029 Viagrande, Italy.
Chiara MondelloInstitute of Molecular Genetics, National Research Council, 27100 Pavia, Italy.
Christian C NausDepartment of Cellular & Physiological Sciences, Life Sciences Institute, Faculty of Medicine, The University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
Richard Ponce-CusiInstituto de Alta Investigacion, Universidad de Tarapaca, Arica 8097877, Chile.
Jayadev RajuToxicology Research Division, Bureau of Chemical Safety Food Directorate, Health Products and Food Branch Health Canada, Ottawa, Ontario K1A0K9, Canada.
Debasish RoyDepartment of Natural Science, The City University of New York at Hostos Campus, Bronx, NY 10451, USA.
Rabindra RoyMolecular Oncology Program, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington DC 20057, USA.
Elizabeth P RyanDepartment of Environmental and Radiological Health Sciences/Colorado State University/Colorado School of Public Health, Fort Collins, CO 80523-1680, USA.
Hosni K SalemUrology Dept., kasr Al-Ainy School of Medicine, Cairo University, El Manial, Cairo 12515, Egypt.
A Ivana ScovassiInstitute of Molecular Genetics, National Research Council, 27100 Pavia, Italy.
Neetu SinghAdvanced Molecular Science Research Centre, King George's Medical University, Lucknow, UP 226003, India.
Monica VaccariCenter for Environmental Carcinogenesis and Risk Assessment, Environmental Protection and Health Prevention Agency, Bologna 40126, Italy.
Renza VentoDepartment of Biological, Chemical, and Pharmaceutical Sciences and Technologies, Polyclinic Plexus, University of Palermo, 90127 Palermo, Italy, Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA.
Jan VondráčekDepartment of Cytokinetics, Institute of Biophysics AS CR, Brno 612 65, Czech Republic.
Mark WadeCenter for Genomic Science of IIT@SEMM, Istituto Italiano di Tecnologia (IIT), Milan 16163, Italy and.
Jordan WoodrickMolecular Oncology Program, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington DC 20057, USA.
William H BissonEnvironmental and Molecular Toxicology, Environmental Health Sciences Center, Oregon State University, Corvallis, OR 97331, USA.
Funding
TRAINING GRANT IN TUMOR BIOLOGYT32CA009686 · NCI · GEORGETOWN UNIVERSITY · PI ANNA Tate RIEGEL, DAVID J ROBBINS · 1996 to 2026
$10.8MRegulations of DNA Alkylation/Deamination Damage RepairR01CA092306 · NCI · INSTITUTE FOR CANCER PREVENTION · PI ROY, RABINDRA · 2003 to 2013
$2.8MMechanisms of Herceptin resistanceR01CA157754 · NCI · EMORY UNIVERSITY · PI NAHTA, RITA · 2012 to 2016
$1.8MMechanisms of PPM1D in medulloblastoma tumorigenesis and invasionR01CA172392 · NCI · EMORY UNIVERSITY · PI CASTELLINO, ROBERT CRAIG · 2013 to 2017
$1.6MPemetrexed and sildenafil for lung cancerR01CA192613 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI DENT, PAUL · 2015 to 2019
$1.6MDNA Repair of Endogenous Lesions in CarcinogenesisR01CA113447 · NCI · GEORGETOWN UNIVERSITY · PI ROY, RABINDRA · 2006 to 2010
$1.4MThe Halifax Project: Chemical Mixtures and CancerR13ES023276 · NIEHS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI CARPENTER, DAVID ORLO · 2013 to 2013
$25kNCI NIH HHS R01 CA092306NCI NIH HHS R01 CA113447NCI NIH HHS R01 CA157754NCI NIH HHS R01CA172392NCI NIH HHS R01 CA192613NCI NIH HHS R01 CA92306NCI NIH HHS R01 CA92306-S1NCI NIH HHS T32 CA009686NIEHS NIH HHS R13 ES023276
Abstract
As part of the Halifax Project, this review brings attention to the potential effects of environmental chemicals on important molecular and cellular regulators of the cancer hallmark of evading growth suppression. Specifically, we review the mechanisms by which cancer cells escape the growth-inhibitory signals of p53, retinoblastoma protein, transforming growth factor-beta, gap junctions and contact inhibition. We discuss the effects of selected environmental chemicals on these mechanisms of growth inhibition and cross-reference the effects of these chemicals in other classical cancer hallmarks.
Indexed as
AnimalsEnvironmental ExposureHazardous SubstancesHumansNeoplasmsSignal TransductionHazardous Substances
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