Evidence map›Paper›PMID 26106137›Full record

ReviewCarcinogenesis2015

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: focus on the cancer hallmark of tumor angiogenesis.

Zhiwei Hu, Samira A Brooks, Valérian Dormoy, Chia-Wen Hsu, Hsue-Yin Hsu, Liang-Tzung Lin, Thierry Massfelder, W Kimryn Rathmell, Menghang Xia, Fahd Al-Mulla and 21 more

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Carcinogenesis, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
6.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 51 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Major roles of the circadian clock in cancer.Cancer biology & medicine · 2023
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  8. Review
  9. Anchoring Metallic MoSACS omega · 2021
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Ethanol Extract fromInternational journal of medical sciences · 2018
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors at 13 institutions in 7 countries.

Zhiwei HuDepartment of Surgery and The James Comprehensive Cancer Center, The Ohio State University College of Medicine, Columbus, OH 43210, USA, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, INSERM U1113, team 3 "Cell Signalling and Communication in Kidney and Prostate Cancer", University of Strasbourg, Facultée de Médecine, 67085 Strasbourg, France, Department of Cell and Developmental Biology, University of California, Irvine, CA 92697, USA, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892-3375, USA, Department of Life Sciences, Tzu-Chi University, Taiwan, Republic of China, Department of Microbiology and Immunology, Taipei Medical University, Taiwan, Republic of China, Department of Pathology, Kuwait University, Safat 13110, Kuwait, Department of Experimental and Clinical Medicine, University of Firenze, Florence 50134, Italy, Department of Environmental and Radiological Health Sciences , Colorado State University/Colorado School of Public Health, Fort Collins, CO 80523, USA, Environmental and Molecular Toxicology, Environmental Health Science Center, Oregon State University, Corvallis, OR 97331, USA, Center for Environmental Carcinogenesis and Risk Assessment, Environmental Protection and Health Prevention Agency, Bologna, Italy, Faculty of Medicine and Health Sciences, University Putra, Serdang, Selangor, Malaysia, Institute of Molecular Genetics, National Research Council, Pavia 27100, Italy, Regulatory Toxicology Research Division, Bureau of Chemical Safety, Food Directorate , Health Products and Food Branch Health Canada, Ottawa, Ontario K1A0K9, Canada, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington DC 20057, USA, Advanced Molecular Science Research Centre (Centre for Advance Research), King George's Medical University, Lucknow, Uttar Pradesh 226003, India, Mediterranean Institute of Oncology, Viagrande 95029,
Samira A BrooksLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Valérian DormoyINSERM U1113, team 3 "Cell Signalling and Communication in Kidney and Prostate Cancer", University of Strasbourg, Facultée de Médecine, 67085 Strasbourg, France, Department of Cell and Developmental Biology, University of California, Irvine, CA 92697, USA.
Chia-Wen HsuNational Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892-3375, USA.
Hsue-Yin HsuDepartment of Life Sciences, Tzu-Chi University, Taiwan, Republic of China.
Liang-Tzung LinDepartment of Microbiology and Immunology, Taipei Medical University, Taiwan, Republic of China.
Thierry MassfelderINSERM U1113, team 3 "Cell Signalling and Communication in Kidney and Prostate Cancer", University of Strasbourg, Facultée de Médecine, 67085 Strasbourg, France.
W Kimryn RathmellLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Menghang XiaNational Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892-3375, USA.
Fahd Al-MullaDepartment of Life Sciences, Tzu-Chi University, Taiwan, Republic of China.
Rabeah Al-TemaimiDepartment of Pathology, Kuwait University, Safat 13110, Kuwait.
Amedeo AmedeiDepartment of Experimental and Clinical Medicine, University of Firenze, Florence 50134, Italy.
Dustin G BrownDepartment of Environmental and Radiological Health Sciences , Colorado State University/Colorado School of Public Health, Fort Collins, CO 80523, USA.
Kalan R PrudhommeEnvironmental and Molecular Toxicology, Environmental Health Science Center, Oregon State University, Corvallis, OR 97331, USA.
Annamaria ColacciCenter for Environmental Carcinogenesis and Risk Assessment, Environmental Protection and Health Prevention Agency, Bologna, Italy.
Roslida A HamidFaculty of Medicine and Health Sciences, University Putra, Serdang, Selangor, Malaysia.
Chiara MondelloInstitute of Molecular Genetics, National Research Council, Pavia 27100, Italy.
Jayadev RajuRegulatory Toxicology Research Division, Bureau of Chemical Safety, Food Directorate , Health Products and Food Branch Health Canada, Ottawa, Ontario K1A0K9, Canada.
Elizabeth P RyanDepartment of Environmental and Radiological Health Sciences , Colorado State University/Colorado School of Public Health, Fort Collins, CO 80523, USA.
Jordan WoodrickLombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington DC 20057, USA.
A Ivana ScovassiInstitute of Molecular Genetics, National Research Council, Pavia 27100, Italy.
Neetu SinghAdvanced Molecular Science Research Centre (Centre for Advance Research), King George's Medical University, Lucknow, Uttar Pradesh 226003, India.
Monica VaccariCenter for Environmental Carcinogenesis and Risk Assessment, Environmental Protection and Health Prevention Agency, Bologna, Italy.
Rabindra RoyLombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington DC 20057, USA.
Stefano ForteMediterranean Institute of Oncology, Viagrande 95029, Italy.
Lorenzo MemeoMediterranean Institute of Oncology, Viagrande 95029, Italy.
Hosni K SalemUrology Department, kasr Al-Ainy School of Medicine, Cairo University, El Manial, Cairo 12515, Egypt.
Leroy LoweGetting to Know Cancer, Truro, Nova Scotia B2N 1X5, Canada.
Lasse JensenDivision of Cardiovascular Medicine, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden and.
William H BissonEnvironmental and Molecular Toxicology, Environmental Health Science Center, Oregon State University, Corvallis, OR 97331, USA.
Nicole KleinstreuerIntegrated Laboratory Systems, Inc., in support of the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, NIEHS, MD K2-16, RTP, NC 27709, USA.
National Center for Advancing Translational Sciences · USOregon State University · USTzu Chi University · TWUniversity of North Carolina at Chapel Hill · USCairo University · EGGeorgetown University · USGeorgetown University Medical Center · USKuwait University · KWLinköping University · SETaipei Medical University · TWThe Ohio State University · USUniversité de Strasbourg · FRUniversiti Putra Malaysia · MY

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Jennifer A. Woyach · 1985 to 2026
$132.3M
TRAINING GRANT IN TUMOR BIOLOGYT32CA009686 · NCI · GEORGETOWN UNIVERSITY · PI ANNA Tate RIEGEL, DAVID J ROBBINS · 1996 to 2026
$10.8M
Toxicology in the 21st Century Program (Tox21) - Systems ToxicologyZIATR000038 · NCATS · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · PI XIA, MENGHANG · 2015 to 2025
$5.7M
Regulations of DNA Alkylation/Deamination Damage RepairR01CA092306 · NCI · INSTITUTE FOR CANCER PREVENTION · PI ROY, RABINDRA · 2003 to 2013
$2.8M
DNA Repair of Endogenous Lesions in CarcinogenesisR01CA113447 · NCI · GEORGETOWN UNIVERSITY · PI ROY, RABINDRA · 2006 to 2010
$1.4M
Inhibiting Corneal Neovascularization by Targeting Tissue FactorR21EY037451 · NEI · OHIO STATE UNIVERSITY · PI HU, ZHIWEI, ZHU, HUA · 2025 to 2025
$433k
The Halifax Project: Chemical Mixtures and CancerR13ES023276 · NIEHS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI CARPENTER, DAVID ORLO · 2013 to 2013
$25k
NCI NIH HHS P30 CA016058NCI NIH HHS R01 CA092306NCI NIH HHS R01 CA113447NCI NIH HHS R01 CA92306NCI NIH HHS R01 CA92306-S1NCI NIH HHS T32 CA009686NEI NIH HHS R21 EY037451NIEHS NIH HHS N01 ES035504NIEHS NIH HHS N01-ES 35504NIEHS NIH HHS R13 ES023276PHS HHS HHSN27320140003C
6 · The paper itself

Abstract

One of the important 'hallmarks' of cancer is angiogenesis, which is the process of formation of new blood vessels that are necessary for tumor expansion, invasion and metastasis. Under normal physiological conditions, angiogenesis is well balanced and controlled by endogenous proangiogenic factors and antiangiogenic factors. However, factors produced by cancer cells, cancer stem cells and other cell types in the tumor stroma can disrupt the balance so that the tumor microenvironment favors tumor angiogenesis. These factors include vascular endothelial growth factor, endothelial tissue factor and other membrane bound receptors that mediate multiple intracellular signaling pathways that contribute to tumor angiogenesis. Though environmental exposures to certain chemicals have been found to initiate and promote tumor development, the role of these exposures (particularly to low doses of multiple substances), is largely unknown in relation to tumor angiogenesis. This review summarizes the evidence of the role of environmental chemical bioactivity and exposure in tumor angiogenesis and carcinogenesis. We identify a number of ubiquitous (prototypical) chemicals with disruptive potential that may warrant further investigation given their selectivity for high-throughput screening assay targets associated with proangiogenic pathways. We also consider the cross-hallmark relationships of a number of important angiogenic pathway targets with other cancer hallmarks and we make recommendations for future research. Understanding of the role of low-dose exposure of chemicals with disruptive potential could help us refine our approach to cancer risk assessment, and may ultimately aid in preventing cancer by reducing or eliminating exposures to synergistic mixtures of chemicals with carcinogenic potential.

Indexed as

AnimalsCarcinogenesisCarcinogens, EnvironmentalEnvironmental ExposureHazardous SubstancesHumansNeoplasmsNeovascularization, PathologicCarcinogens, EnvironmentalHazardous Substances

Identifiers

PMID26106137
PMCPMC4492067
OpenAlexW2134835775

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.