ArticleInternational journal of bipolar disorders2015
Development of a bipolar disorder biobank: differential phenotyping for subsequent biomarker analyses.
Article in International journal of bipolar disorders, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Persistence of Lithium Underutilization in Patients of African Ancestry with Bipolar Disorder.Psychopharmacology bulletin · 2025Pooled it
- Thyroid peroxidase antibodies in bipolar disorder: implications for clinical sub-phenotypes and lithium response.International journal of bipolar disorders · 2026Article
- The anxious bipolar phenotype: clinical complexity and treatment response.International journal of bipolar disorders · 2026Article
- Unhealthy diet quality as a clinical phenotype in bipolar disorder: A potential treatment target for improved mood and metabolic outcomes.Journal of affective disorders · 2026Article
- Acid accumulation in bipolar disorder.Journal of affective disorders · 2026Article
- The Anxious Bipolar Phenotype: Clinical Complexity and Treatment Resistance.Research square · 2026Article
- Antipsychotic use in bipolar disorder: clinical and genomic correlates- a Mayo clinic bipolar disorder biobank study.International journal of bipolar disorders · 2025Article
- A Cross-Sectional Analysis of Social Determinants of Health in Bipolar Disorder: Exploring Gender-Related Differences.Bipolar disorders · 2025Article
- Implications of the choice of method to identify major depressive disorder in large research cohorts.Journal of mood and anxiety disorders · 2025Article
- Antipsychotic Use in Bipolar Disorder: Clinical and Genomic Correlates- A Mayo Clinic Bipolar Disorder Biobank Study.Research square · 2025Article
- Bipolar II disorder: a state-of-the-art review.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2025Article
- Exploration of Genetic Liability to Insomnia and Substance Use Disorders in Patients With Bipolar Disorder.Bipolar disorders · 2025Article
- Differential serum levels of CACNA1C, circadian rhythm and stress response molecules in subjects with bipolar disorder: Associations with genetic and clinical factors.Journal of affective disorders · 2024Article
- Clinical and genetic contributions to medical comorbidity in bipolar disorder: a study using electronic health records-linked biobank data.Molecular psychiatry · 2024Article
- Differential Serum Levels of CACNA1C, Circadian Rhythm and Stress Response Molecules in Subjects with Bipolar Disorder: Associations with Genetic and Clinical Factors.medRxiv : the preprint server for health sciences · 2024Article
- Antidepressants that increase mitochondrial energetics may elevate risk of treatment-emergent mania.Molecular psychiatry · 2023Article
- Long-Term Lithium Therapy and Thyroid Disorders in Bipolar Disorder: A Historical Cohort Study.Brain sciences · 2023Article
- Quantification of diet quality utilizing the rapid eating assessment for participants-shortened version in bipolar disorder: Implications for prospective depression and cardiometabolic studies.Journal of affective disorders · 2022Article
- Clinical and Genetic Correlates of Bipolar Disorder With Childhood-Onset Attention Deficit Disorder.Frontiers in psychiatry · 2022Article
- TCF7L2 lncRNA: a link between bipolar disorder and body mass index through glucocorticoid signaling.Molecular psychiatry · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Funding
Abstract
backgroundWe aimed to establish a bipolar disorder biobank to serve as a resource for clinical and biomarker studies of disease risk and treatment response. Here, we describe the aims, design, infrastructure, and research uses of the biobank, along with demographics and clinical features of the first participants enrolled.
methodsPatients were recruited for the Mayo Clinic Bipolar Biobank beginning in July 2009. The Structured Clinical Interview for DSM-IV was used to confirm bipolar diagnosis. The Bipolar Biobank Clinical Questionnaire and Participant Questionnaire were designed to collect detailed demographic and clinical data, including clinical course of illness measures that would delineate differential phenotypes for subsequent analyses. Blood specimens were obtained from participants, and various aliquots were stored for future research.
resultsAs of September 2014, 1363 participants have been enrolled in the bipolar biobank. Among these first participants, 69.0 % had a diagnosis of bipolar disorder type I. The group was 60.2 % women and predominantly white (90.6 %), with a mean (SD) age of 42.6 (14.9) years. Clinical phenotypes of the group included history of psychosis (42.3 %), suicide attempt (32.5 %), addiction to alcohol (39.1 %), addiction to nicotine (39.8 %), obesity (42.9 %), antidepressant-induced mania (31.7 %), tardive dyskinesia (3.2 %), and history of drug-related serious rash (5.7 %).
conclusionsQuantifying phenotypic patterns of illness beyond bipolar subtype can provide more detailed clinical disease characteristics for biomarker research, including genomic-risk studies. Future research can harness clinically useful biomarkers using state-of-the-art research technology to help stage disease burden and better individualize treatment selection for patients with bipolar disorder.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.