Evidence map›Paper›PMID 26105532›Full record

ArticleDrug delivery and translational research2016

In vivo comparison of biomineralized scaffold-directed osteogenic differentiation of human embryonic and mesenchymal stem cells.

Cai Wen, Heemin Kang, Yu-Ru V Shih, YongSung Hwang, Shyni Varghese

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Drug delivery and translational research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
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  4. Static and Dynamic Biomaterial Engineering for Cell Modulation.Nanomaterials (Basel, Switzerland) · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Cai WenSchool of Chemistry and Chemical Engineering, Southeast University, Sipailou 2#, Nanjing, Jiangsu Province, 210096, People's Republic of China.
Heemin KangDepartment of Bioengineering, University of California- San Diego, 9500, Gilman Drive, La Jolla, CA, 92093-0412, USA.
Yu-Ru V ShihDepartment of Bioengineering, University of California- San Diego, 9500, Gilman Drive, La Jolla, CA, 92093-0412, USA.
YongSung HwangDepartment of Bioengineering, University of California- San Diego, 9500, Gilman Drive, La Jolla, CA, 92093-0412, USA.
Shyni VargheseDepartment of Bioengineering, University of California- San Diego, 9500, Gilman Drive, La Jolla, CA, 92093-0412, USA. svarghese@ucsd.edu.

Funding

PREPARATION AND DISTRUBUTION OF ADULT STEM CELLS: HUMAN &RODENTP40RR017447 · NCRR · TULANE UNIVERSITY OF LOUISIANA · PI PROCKOP, DARWIN JOHNSON · 2003 to 2011
$8.9M
Diversity Supplement -"Bioinspired Synthetic Grafts for Bone Regeneration"R01AR063184 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI VARGHESE, SHYNI · 2013 to 2017
$1.7M
NCRR NIH HHS P40RR017447NIAMS NIH HHS 1 R01 AR063184-01A1
6 · The paper itself

Abstract

Human pluripotent stem cells such as embryonic stem cells (hESCs) and multipotent stem cells like mesenchymal stem cells (hMSCs) hold great promise as potential cell sources for bone tissue regeneration. Comparing the in vivo osteogenesis of hESCs and hMSCs by biomaterial-based cues provides insight into the differentiation kinetics of these cells as well as their potential to contribute to bone tissue repair in vivo. Here, we compared in vivo osteogenic differentiation of hESCs and hMSCs within osteoinductive calcium phosphate (CaP)-bearing biomineralized scaffolds that recapitulate a bone-specific mineral microenvironment. Both hESCs and hMSCs underwent osteogenic differentiation responding to the biomaterial-based instructive cues. Furthermore, hMSCs underwent earlier in vivo osteogenesis compared to hESCs, but both stem cell types acquired a similar osteogenic maturation by 8 weeks of implantation.

Indexed as

AnimalsCalcification, PhysiologicCalcium PhosphatesCell DifferentiationCells, CulturedEmbryonic Stem CellsHumansMesenchymal Stem CellsMiceOsteogenesisStem Cell TransplantationTissue Scaffoldscalcium phosphateCalcium PhosphatesBiomineralized scaffoldBone tissue engineeringCalcium phosphateEmbryonic stem cellsIn vivo osteogenic differentiationMesenchymal stem cells

Identifiers

PMID26105532

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.