Evidence map›Paper›PMID 26105529›Full record

Trial reportEuropean journal of applied physiology2015

Ipsilateral resistance exercise prevents exercise-induced central sensitization in the contralateral limb: a randomized controlled trial.

Mahdi Hosseinzadeh, Afshin Samani, Ole K Andersen, Kazunori Nosaka, Lars Arendt-Nielsen, Pascal Madeleine

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of applied physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02730598 (Determining Efficacy of the Combined Application of Electrical Stimulated Antagonist Contraction During Walking With Sensory TENS for Increasing Strength and Decreasing Pain in Women With Frequent Knee Symptoms), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02730598 nacompletednot on this mapstarted 2016, after this paper: background citation

Determining Efficacy of the Combined Application of Electrical Stimulated Antagonist Contraction During Walking With Sensory TENS for Increasing Strength and Decreasing Pain in Women With Frequent Knee Symptoms

TypeinterventionalSponsorUniversity of Kansas Medical CenterRan2016 to 2017Enrolled28ConditionsKnee OsteoarthritisArmsHybrid Training System (HTS), Sensory TENS
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mahdi HosseinzadehPhysical Activity and Human Performance Group, SMI, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7 D-3, 9220, Aalborg, Denmark.
Afshin SamaniPhysical Activity and Human Performance Group, SMI, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7 D-3, 9220, Aalborg, Denmark.
Ole K AndersenPhysical Activity and Human Performance Group, SMI, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7 D-3, 9220, Aalborg, Denmark.
Kazunori NosakaCentre for Exercise and Sports Science Research, School of Exercise and Health Sciences, Edith Cowan University, Joondalup, WA, Australia. k.nosaka@ecu.edu.au.
Lars Arendt-NielsenPhysical Activity and Human Performance Group, SMI, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7 D-3, 9220, Aalborg, Denmark.
Pascal MadeleinePhysical Activity and Human Performance Group, SMI, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7 D-3, 9220, Aalborg, Denmark. pm@hst.aau.dk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aimed to investigate the hypothesis that a repeated bout of eccentric exercise (ECC2) would result in smaller increase in the sensitivity of spinal nociceptive system, and smaller decrease in the local muscle blood oxygenation response in both the ipsilateral and the contralateral tibialis anterior muscle (TA) when compared with the initial bout (ECC1). It was hypothesized that the magnitude of the repeated bout effect (RBE) would be greater for the ipsilateral side than the contralateral side.

methodsTwenty-six healthy young men performed two bouts of high-intensity eccentric exercise of TA separated by 2 weeks. Half of the participants used the same leg for both bouts (IPSI) and the other half used the contralateral leg for ECC2 (CONTRA). Nociceptive withdrawal reflex threshold (NWRT) and local muscle blood oxygenation were assessed for the exercised TA muscle before, immediately after, and one day after exercise.

resultsSignificant decreases in NWRT and muscle oxygenation were observed after ECC1 (p < 0.05), but NWRT did not change after ECC2 in both groups. Smaller decreases in muscle oxygenation were observed after ECC2 than ECC1 in both groups with a similar magnitude of the difference between bouts, but an increase in muscle oxygen re-perfusion before ECC2 was only observed in the IPSI group.

conclusionThese results suggest that contralateral RBE was associated with spinal facilitation of the neuronal pathways situated at a homologous innervation level, and it is unlikely that oxygen re-perfusion improvement plays a major role in the contralateral RBE.

Indexed as

Resistance TrainingAdultCentral Nervous System SensitizationElectromyographyExerciseHumansIsometric ContractionMaleMuscle, SkeletalRange of Motion, ArticularYoung AdultCross-transfer effectEccentric exerciseMuscle oxygenationNociceptive withdrawal reflex thresholdRepeated bout effect

Identifiers

PMID26105529

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.