ReviewHuman molecular genetics2015
Epigenetic mechanisms in diurnal cycles of metabolism and neurodevelopment.
Review in Human molecular genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Writing the Engram: Epigenetic Mechanisms of Memory Allocation.Journal of neurochemistry · 2025Review
- Sleep and circadian disturbances in children with neurodevelopmental disorders.Nature reviews. Neurology · 2025Review
- The Promise of DNA Methylation in Understanding Multigenerational Factors in Autism Spectrum Disorders.Frontiers in genetics · 2022Review
- Neuroendocrine, epigenetic, and intergenerational effects of general anesthetics.World journal of psychiatry · 2020Review
- Circadian BMAL1 regulates mandibular condyle development by hedgehog pathway.Cell proliferation · 2020Article
- Insights About Circadian Clock and Molecular Pathogenesis in Gliomas.Frontiers in oncology · 2020Review
- Circadian biology and sleep in monogenic neurological disorders and its potential application in drug discovery.Current opinion in behavioral sciences · 2019Article
- Testicular MTHFR deficiency may explain sperm DNA hypomethylation associated with high dose folic acid supplementation.Human molecular genetics · 2018Article
- BMAL1 Deficiency Contributes to Mandibular Dysplasia by Upregulating MMP3.Stem cell reports · 2018Article
- "I Am I and My Bacterial Circumstances": Linking Gut Microbiome, Neurodevelopment, and Depression.Frontiers in psychiatry · 2017Review
- Role of histone acetylation in long-term neurobehavioral effects of neonatal Exposure to sevoflurane in rats.Neurobiology of disease · 2016Article
- Genomic Imprinting: A New Epigenetic Perspective of Sleep Regulation.PLoS genetics · 2016Review
- Nutrigenetics and Nutrimiromics of the Circadian System: The Time for Human Health.International journal of molecular sciences · 2016Review
- Economic hardship and biological weathering: The epigenetics of aging in a U.S. sample of black women.Social science & medicine (1982) · 2016Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The circadian cycle is a genetically encoded clock that drives cellular rhythms of transcription, translation and metabolism. The circadian clock interacts with the diurnal environment that also drives transcription and metabolism during light/dark, sleep/wake, hot/cold and feast/fast daily and seasonal cycles. Epigenetic regulation provides a mechanism for cells to integrate genetic programs with environmental signals in order produce an adaptive and consistent output. Recent studies have revealed that DNA methylation is one epigenetic mechanism that entrains the circadian clock to a diurnal environment. We also review recent circadian findings in the epigenetic neurodevelopmental disorders Prader-Willi, Angelman and Rett syndromes and hypothesize a link between optimal brain development and intact synchrony between circadian and diurnal rhythms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.