ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2016
Not All Antidepressants Are Created Equal: Differential Effects of Monoamine Uptake Inhibitors on Effort-Related Choice Behavior.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 79 citations in OpenAlex.
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- Decoding instrumental lever pressing from prefrontal, accumbens, and hippocampal local field potentials: conservation across sex, task, and dopamine depletion.bioRxiv : the preprint server for biology · 2026Article
- Neurochemical drivers of effort: The roles of dopamine and beyond in physical and cognitive exertion.Neuroscience and biobehavioral reviews · 2026Review
- Review
- Dopamine antagonist effects of the D2/D3 receptor partial agonist aripiprazole on effort-based choice tasks in male and female rats.Cognitive, affective & behavioral neuroscience · 2026Article
- Conditioned versus innate effort-based tasks reveal divergence in antidepressant effect on motivational state in male mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Follicle-stimulating hormone: More than a marker for menopause: FSH as a frontier for women's mental health.Psychiatry research · 2025Review
- Pharmacological characterization of sex differences in the effects of dopaminergic drugs on effort-based decision making in rats.Psychopharmacology · 2024Article
- Neurobiological foundations and clinical relevance of effort-based decision-making.Brain imaging and behavior · 2024Review
- Potential therapeutics for effort-related motivational dysfunction: assessing novel atypical dopamine transport inhibitors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Sex and age differences in mice models of effort-based decision-making and anergia in depression: the role of dopamine, and cerebral-dopamine-neurotrophic-factor.Psychopharmacology · 2023Article
- Effects of the dopamine depleting agent tetrabenazine in tests evaluating different components of depressive-like behavior in mice: sex-dependent response to antidepressant drugs with SERT and DAT blocker profiles.Psychopharmacology · 2023Article
- Effects of the dopamine depleting agent tetrabenazine on detailed temporal parameters of effort-related choice responding.Journal of the experimental analysis of behavior · 2022Article
- Different depression: motivational anhedonia governs antidepressant efficacy in Huntington's disease.Brain communications · 2022Article
- Vigor, Effort-Related Aspects of Motivation and Anhedonia.Current topics in behavioral neurosciences · 2022Review
- Energizing effects of bupropion on effortful behaviors in mice under positive and negative test conditions: modulation of DARPP-32 phosphorylation patterns.Psychopharmacology · 2021Article
- Perinatal interference with the serotonergic system affects VTA function in the adult via glutamate co-transmission.Molecular psychiatry · 2021Article
- Chronic Augmentation of Endocannabinoid Levels Persistently Increases Dopaminergic Encoding of Reward Cost and Motivation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Apathy after stroke: Diagnosis, mechanisms, consequences, and treatment.International journal of stroke : official journal of the International Stroke Society · 2021Review
- Sex differences in effort-related decision-making: role of dopamine D2 receptor antagonism.Psychopharmacology · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Motivated behavior can be characterized by behavioral activation and high work output. Moreover, people with depression and other disorders show effort-related motivational symptoms, such as anergia, psychomotor retardation, and fatigue. Effort-based decision making is studied using tasks offering choices between high effort options leading to highly valued reinforcers vs low effort/low reward options, and such tasks could be useful as animal models of motivational symptoms. In the present studies the effort-related effects of the vesicular monoamine transport (VMAT-2) inhibitor tetrabenazine (TBZ) were investigated. TBZ blocks vesicular storage and also produces depressive symptoms in humans. Moreover, TBZ alters effort-based choice in rats, biasing animals toward low effort alternatives. The present studies investigated the ability of acute administration of various monoamine uptake inhibitors to reverse the effects of TBZ. Effort-related effects of TBZ were attenuated by the catecholamine uptake inhibitor and antidepressant bupropion, and this effect of bupropion was reversed by either D1 or D2 family antagonism. The effort-related effects of TBZ were also attenuated by the selective dopamine uptake blocker GBR12909. The 5-HT uptake inhibitor fluoxetine and the norepinephrine uptake inhibitor desipramine failed to reverse the effects of TBZ, and higher doses of these drugs, given alone or in combination with TBZ, led to further behavioral impairments. These results indicate that drugs acting on dopamine transmission are relatively effective at reversing the effort-related effects of TBZ, and are consistent with the hypothesis that drugs that enhance dopamine transmission may be effective at treating effort-related psychiatric symptoms in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.