ReviewCurrent diabetes reports2015
Health effects of fructose and fructose-containing caloric sweeteners: where do we stand 10 years after the initial whistle blowings?
Review in Current diabetes reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Cognitive and neuroanatomical effects of chronic high-fructose corn syrup consumption in the aging rat brain.BMC neuroscience · 2025Article
- Could Insulin Be a Better Regulator of Appetite/Satiety Balance and Body Weight Maintenance in Response to Glucose Exposure Compared to Sucrose Substitutes? Unraveling Current Knowledge and Searching for More Appropriate Choices.Medical sciences (Basel, Switzerland) · 2024Review
- Investigation of fructose consumption on hippocampal insulin and glucagon-like peptide-1 receptors, and metabolic effects in rats.Iranian journal of basic medical sciences · 2023Article
- Importance of Carbohydrate Quality: What Does It Mean and How to Measure It?The Journal of nutrition · 2022Review
- Dietary fructose and risk of metabolic syndrome in Chinese residents aged 45 and above: results from the China National Nutrition and Health Survey.Nutrition journal · 2021Article
- A comprehensive policy for reducing sugar beverages for healthy life extension.Environmental health and preventive medicine · 2019Article
- The FGF21 response to fructose predicts metabolic health and persists after bariatric surgery in obese humans.Molecular metabolism · 2017Article
- Review
- New perspectives on the nutritional factors influencing growth rate of Candida albicans in diabetics. An in vitro study.Memorias do Instituto Oswaldo Cruz · 2017Article
- Type of supplemented simple sugar, not merely calorie intake, determines adverse effects on metabolism and aortic function in female rats.American journal of physiology. Heart and circulatory physiology · 2017Article
- Chronic psychological stress and high-fat high-fructose diet disrupt metabolic and inflammatory gene networks in the brain, liver, and gut and promote behavioral deficits in mice.Brain, behavior, and immunity · 2017Article
- Relationship between Added Sugars Consumption and Chronic Disease Risk Factors: Current Understanding.Nutrients · 2016Review
- Sweeteners and health: findings from recent research and their impact on obesity and related metabolic conditions.International journal of obesity (2005) · 2016Review
- Added sugars and risk factors for obesity, diabetes and heart disease.International journal of obesity (2005) · 2016Review
- Does Natural Honey-Containing Fructose have Benefits to Diabetic Patients?The Malaysian journal of medical sciences : MJMS · 2016Article
- Physiological handling of dietary fructose-containing sugars: implications for health.International journal of obesity (2005) · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Suspicion that fructose-containing caloric sweeteners (FCCS) may play a causal role in the development of metabolic diseases has elicited intense basic and clinical research over the past 10 years. Prospective cohort studies converge to indicate that FCCS, and more specifically sugar-sweetened beverages (SSBs), consumption is associated with weight gain over time. Intervention studies in which FCCS or SSB consumption is altered while food intake is otherwise left ad libitum indicate that increased FCCS generally increases total energy intake and body weight, while FCCS reduction decreases body weight gain. Clinical trials assessing the effects of SSB reduction as a sole intervention however fail to observe clinically significant weight loss. Many mechanistic studies indicate that excess FCCS can cause potential adverse metabolic effects. Whether this is associated with a long-term risk remains unknown. Scientific evidence that excess FCCS intake causes more deleterious effects to health than excess of other macronutrients is presently lacking. However, the large consumption of FCCS in the population makes it one out of several targets for the treatment and prevention of metabolic diseases.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.