ReviewMicrobiology spectrum2015
Mechanisms of Theta Plasmid Replication.
Review in Microbiology spectrum, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed.
- MOSAIC: A Highly Efficient, One-Step Recombineering Approach to Plasmid Editing and Diversification.ACS synthetic biology · 2025Article
- OriV-Finder: a comprehensive web server for bacterial plasmid replication origin analysis.Nucleic acids research · 2025Article
- Mutational features of chromids and chromosomes inMicrobiology spectrum · 2025Article
- The insertion of the inverted repeat of an insertion sequence (IS) element fromApplied and environmental microbiology · 2025Article
- Reducing competition between msd and genomic DNA improves retron editing efficiency.EMBO reports · 2024Article
- Article
- Generating a Small Shuttle Vector for Effective Genetic Engineering ofInternational journal of molecular sciences · 2022Article
- Plasmid-Based Gene Expression Systems for Lactic Acid Bacteria: A Review.Microorganisms · 2022Review
- The Burkholderia cenocepacia iron starvation σ factor, OrbS, possesses an on-board iron sensor.Nucleic acids research · 2022Article
- SkewDB, a comprehensive database of GC and 10 other skews for over 30,000 chromosomes and plasmids.Scientific data · 2022Article
- Novel shuttle vector pGMβ1 for conjugative chromosomal manipulation ofBioscience of microbiota, food and health · 2022Article
- Evolution of ColE1-like plasmids across γ-Proteobacteria: From bacteriocin production to antimicrobial resistance.PLoS genetics · 2021Article
- Differential Chromosome- and Plasmid-Borne Resistance ofInternational journal of molecular sciences · 2021Article
- Mechanisms of Theta Plasmid Replication in Enterobacteria and Implications for Adaptation to Its Host.EcoSal Plus · 2020Review
- Reproducible Antigen Recognition by the Type I-F CRISPR-Cas System.The CRISPR journal · 2020Article
- The Large pBS32/pLS32 Plasmid of Ancestral Bacillus subtilis.Journal of bacteriology · 2020Review
- Genomics of Atlantic ForestMicrobial genomics · 2020Article
- A regulated synthetic operon facilitates stable overexpression of multigene terpenoid pathway in Bacillus subtilis.Journal of industrial microbiology & biotechnology · 2020Article
- Typing methods based on whole genome sequencing data.One health outlook · 2020Review
- Molecular dissection of the replication system of plasmid pIGRK encoding two in-frame Rep proteins with antagonistic functions.BMC microbiology · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Plasmids are autonomously replicating pieces of DNA. This article discusses theta plasmid replication, which is a class of circular plasmid replication that includes ColE1-like origins of replication popular with expression vectors. All modalities of theta plasmid replication initiate synthesis with the leading strand at a predetermined site and complete replication through recruitment of the host's replisome, which extends the leading strand continuously while synthesizing the lagging strand discontinuously. There are clear differences between different modalities of theta plasmid replication in mechanisms of DNA duplex melting and in priming of leading- and lagging-strand synthesis. In some replicons duplex melting depends on transcription, while other replicons rely on plasmid-encoded trans-acting proteins (Reps); primers for leading-strand synthesis can be generated through processing of a transcript or in other replicons by the action of host- or plasmid-encoded primases. None of these processes require DNA breaks. The frequency of replication initiation is tightly regulated to facilitate establishment in permissive hosts and to achieve a steady state. The last section of the article reviews how plasmid copy number is sensed and how this feedback modulates the frequency of replication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.