SynthesisLung2015
Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia of the Lung (DIPNECH): Current Best Evidence.
Synthesis in Lung, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 74 citations in OpenAlex.
- Clinical characteristics of diffuse idiopathic pulmonary neuroendocrine cell hyperplasia.ERJ open research · 2026Article
- Metastatic neuroendocrine lesions in diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH): a narrative review and case series.Endocrine oncology (Bristol, England) · 2026Review
- Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia associated with lung adenocarcinoma: clinical, pathological and oncological outcomes from a multicentre analysis.ERJ open research · 2025Article
- Review
- A multidisciplinary approach to the work up and management of pulmonary carcinoid tumors and DIPNECH: a narrative review.Translational lung cancer research · 2022Review
- A case of multiple lung carcinoid tumors localized in the right lower lobe.Respiratory medicine case reports · 2022Article
- Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia: A Clinical Case.European journal of case reports in internal medicine · 2020Article
- Article
- Gross handling of pulmonary resection specimen: maintaining the 3-dimensional orientation.Journal of thoracic disease · 2019Review
- Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: Case series and a review of the literature.Medicine · 2018Review
- Review
- Clinical and Pathologic Characteristics of Pulmonary Carcinoid Tumors in Central and Peripheral Locations.Endocrine pathology · 2018Article
- Conjunction of a Fungus Ball and a Pulmonary Tumourlet in a Bronchiectatic Cavity.The Korean journal of thoracic and cardiovascular surgery · 2018Article
- An evolutionary perspective on field cancerization.Nature reviews. Cancer · 2018Review
- Management of pulmonary neuroendocrine tumors.Reviews in endocrine & metabolic disorders · 2017Review
- Surgical treatment of synchronous multiple neuroendocrine lung tumours (case series): is more always better?Annals of translational medicine · 2017Article
- Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia: A Case Report and Review of the Literature.The American journal of case reports · 2017Review
- Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia diagnosed by transbronchial lung cryobiopsy: a case report.Journal of medical case reports · 2017Article
- Expression of developing neural transcription factors in diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH).Virchows Archiv : an international journal of pathology · 2016Article
- Pulmonary Peripheral Carcinoids after Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia and Tumorlets: Report of 3 Cases.Case reports in pulmonology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is recognized as a preneoplastic condition by the World Health Organization. We reviewed our experience with 30 patients and performed a systematic review of the English literature to collect best evidence on the clinical features and disease course in 169 additional patients. Some patients presented with one or more carcinoid tumors associated with multiple small pulmonary nodules on imaging studies and showed DIPNECH as a somewhat unexpected pathologic finding. Others presented with multiple small pulmonary nodules that raised suspicion of metastatic disease on imaging. A third subset was presented with previously unexplained respiratory symptoms. In most patients, DIPNECH was associated with a good prognosis, with chronological progression into a subsequent carcinoid tumor noted in only one patient and death attributed directly to DIPNECH in only two patients. There is no best evidence to support the use of octreotide, steroids, or bronchodilators in DIPNECH patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.